Nadège ROCHE-LABARBE, PhD

Photon Migration Imaging Laboratory
Massachusetts General Hospital
Martinos Center for Biomedical Imaging
Building 149 – 13th Street
Charlestown, MA 02129, USA

Room : 2277
Phone : (617) 726-9332
Fax : 617-726-7422
nadege@nmr.mgh.harvard.edu

Research interests

I am a Biologist interested in brain development, cognition and behavior.
My main project consists of making a Near Infrared Spectroscopy clinical tool, intended primarily for neonates and infants, and investigating the haemodynamic aspect of brain development and its relationships with brain function, maturation, and pathological evolution.

Education

2003-2007 : Ph.D. Thesis in Biology, option Neuroscience (Jules Verne University, Amiens, France)
"Coupling EEG and Near Infrared Spectroscopy (NIRS) to study the cerebral function and maturation in premature neonates" Thesis
2001-2003 : M.Sc. "Neuroscience, Behaviour and Cognition" (Paul Sabatier University, Toulouse, France)
2000-2001 : B.Sc. Animal Biology (Paul Sabatier University, Toulouse, France)

Patent

"Probe for detection of brain activity signals," French patent # 0602686, Contribution F. Wallois : 80 %, N. Roche-Labarbe : 20 %

Peer-reviewed articles

N. Roche-Labarbe, S. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, M. A. Franceschini. Non-invasive optical measures of CBV, StO², CBF index, and rCMRO² in human premature neonates’ brains in the first 6 weeks of life. Human Brain Mapping (accepted June 2009).

P. E. Grant, N. Roche-Labarbe, A. Surova, G. Themelis, J. Selb, E. K. Warren, K. S. Krishnamoorthy, D. A. Boas, M. A. Franceschini. Increased Cerebral Blood Volume and Oxygen Consumption in Neonatal Brain Injury. Journal of Cerebral Blood Flow and Metabolism (accepted June 2009).

N. Roche-Labarbe, B. Zaaimi, P. Berquin, A. Nehlig, R. Grebe, F. Wallois. (2008) NIRS-measured oxy- and deoxy-hemoglobin changes associated with EEG spike-and-wave discharges in children. Epilepsia 49(11):1871-80. (PDF)

N. Roche-Labarbe, F. Wallois, E. Ponchel, G. Kongolo, R. Grebe. (2007) Coupled oxygenation oscillation measured by NIRS and intermittent cerebral activation on EEG in premature infants. NeuroImage 36(3):718-727. (PDF)

N. Roche-Labarbe, A. Aarabi, G. Kongolo, C. Gondry-Jouet, M. Dümpelmann, R. Grebe., F. Wallois. (2008). High resolution EEG and source localization in neonates. Human Brain Mapping 29(2):167-76. (PDF)

Peer-reviewed conference proceedings

N. Roche-Labarbe, G. Kongolo, R. Grebe, F. Wallois. Haemodynamic Response Measured by NIRS to Physiological Intermittent Cerebral Activation during Quiet Sleep in Healthy and Sick Premature Neonates. Conference Proceedings of the Optics and Photonics Congress (BIOMED), 2008, St Petersburg, FL, USA.

N. Roche Labarbe, A. Aarabi, G. Kongolo, R. Grebe, F. Wallois. (2006) The link between Near Infrared Spectroscopy (NIRS) and EEG baseline signals in neonates : a possible clinical routine application for the NIRS technique. Conference Proceedings of the 12th Annual Meeting of the Human Brain Mapping Society, Florence, Italy. NeuroImage, vol.31, suppl. 1.

Roche Labarbe N, Barathon M, Berquin P, Grebe R, Wallois F. Simultaneous Recording of Electroencephalography (EEG) and Near Infrared Spectroscopy (NIRS) in a 3 Months Old Infant Suffering from Refractory Epilepsy. Conference Proceedings of the International Epilepsy Congress 2005, Paris, France. Epilepsia, vol. 46, suppl. 6.

Wallois F, Aarabi A, Roche Labarbe N, Grebe R. Principal and Independent Component Analysis of Automatically Detected Positive Temporal Sharp Waves for Source Localisation in Neonates. Conference Proceedings of the International Epilepsy Congress 2005, Paris, France. Epilepsia, vol. 46, suppl. 6.

N. Roche-Labarbe, A. Aarabi, R. Grebe and F. Wallois. (2005). Spontaneous oscillations of cerebral oxy- and deoxy- hemoglobin concentrations are correlated to EEG physiological discontinuity in premature infants. Conference Proceedings of the European Conference on Biomedical Optics, 2005, Munich, Germany.

Aarabi, A., Roche-Labarbe, N., Montigny, A., Gondry, C., Kongolo, G., Berquin, P., Van Burik, M., Grebe, R., Wallois, F. (2004) Automatic spike detection for source localization in children and neonates. Conference Proceedings of the Annual Meeting of the American Epilepsy Society, 2004, New Orleans, USA.

Roche-Labarbe, N., Aarabi, A., Kongolo, G., Krim, G., Grebe, R., Wallois, F. (2004) Electroencephalographic (EEG) dipole source localization in preterm neonates. Conference Proceedings of the Forum of the European Neuroscience Society, 2004, Lisbon, Portugal.

Non-research interests

• Board Member of the Mass General Post-Doc Association (MGPA)

My passion is horse-riding, especially dressage. I also play tennis (not very well but I enjoy it !) and learn Salsa.