Book Chapter

Anand T. N. Kumar "Fluorescence Lifetime-Based Optical Molecular Imaging," in Molecular Imaging Methods and Protocols Series: Methods in Molecular Biology, Vol. 680 Shah, Khalid (Ed.) Humana Press (2011).

Anand T. N. Kumar, "Tomographic fluorescence lifetime imaging," Chapter 16 in Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics, CRC Press; 1 edition, Marcu, L., French, P.M and Elson, D.S (Ed.) (2014).

Journal Articles*

Anand T. N. Kumar, William L. Rice, Jessica C. Lopez, Suresh Gupta, Craig J Goergen and Alexei A. Bogdanov, "Substrate-based near-infrared imaging sensors enable fluorescence lifetime contrast via built-in dynamic fluorescence quenching elements," ACS Sensors (accepted Feb 2016) 

William L. Rice, Daria Shcherbakova, Vladislav Verkhusha and  Anand T. N. Kumar, “In vivo tomographic imaging of deep seated cancer using fluorescence lifetime contrast,” Cancer Research, Vol. 75 (7), pp 1236-43 (2015)

William L. Rice and Anand T. N. Kumar, "Preclinical whole body time domain fluorescence lifetime multiplexing of fluorescent proteins," J. Biomed. Opt. 19 (4), 046004; doi: 10.1117/1.JBO.19.4.046004 (2014).

Steven S. Hou, William L. Rice, Brian J. Bacskai and Anand T. N. Kumar, "Tomographic Lifetime Imaging using Combined Early and Late Arriving Photons," Optics Letters, Vol. 39, Iss 5, pp. 1165-1168 (2014)

V. Metelev, S. Zhang, D. Tabatadze, A. T. N. Kumar and A.A.. Bogdanov, "The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores," Mol. BioSyst., 213, 447 (2013).

William L Rice, Steven Hou and Anand T. N. Kumar, "Resolution below the point spread function for diffuse optical imaging using fluorescence lifetime multiplexing," Optics Letters, Vol. 38, No. 12, pp. 2038-2040 (2013) .

Anand T. N. Kumar, "Fluorescence lifetime detection in turbid media using spatial frequency domain filtering of time domain measurements," Optics Letters, Vol. 37, Iss. 22, pp. 4783-4785 (2013).

Guo Y, Yuan H, Rice W.L., Kumar A.T.N, Goergen C.J., Jokivarsi K, and Lee Josephson "The PEG-Fluorochrome Shielding Approach for Targeted Probe Design," J. Am Chem. Soc., Vol. 134, Iss. 47, pp. 19338-19341 (2012).

Anand T. N. Kumar, " Direct Monte-Carlo computation of time-resolved fluorescence in heterogeneous turbid media," Optics Letters, Vol. 37, Iss. 22, pp. 4783-4785 (2012).

Alexei Bogdanov, Valeriy Metelev, Surong Zhang and Anand T.N. Kumar "Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes," Mol. BioSyst., 8, 2166-2173 (2012).

Craig J. Goergen, Howard H. Chen, Alexei Bogdanov, Jr., David E. Sosnovik, and Anand T. N. Kumar "In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium ," J. Biomed. Opt. 17, 056001 (2012).

Scott B. Raymond, David A. Boas, Brian J. Bacskai and Anand T. N. Kumar "Lifetime-based tomographic multiplexing," J. Biom. Opt., 15, 046011 (2010).

Scott B. Raymond, Anand T. N. Kumar, David A. Boas, and Brian J. Bacskai "Optimal parameters for near infrared fluorescence imaging of amyloid plaques in Alzheimer's disease mouse models," Phys. Med. Bio. 54, 6201 (2009).

Anand T. N. Kumar, Euiheon Chung, Scott B. Raymond, Jeroen Van de Water, Khalid Shah, Dai Fukumura, Rakesh K Jain, Brian J. Bacskai and David A. Boas, "Feasibility of in-vivo imaging of fluorescent proteins using lifetime contrast," Opt. Lett. 34, 2067 (2009).

Anand T. N. Kumar, Scott B. Raymond, Andrew K. Dunn, Brian J. Bacskai and David A. Boas, "A Time Domain Fluorescence Tomography System for Small Animal Imaging," IEEE Trans. Med. Imag., 27, 1152-1163 (2008).

Anand T. N. Kumar, Scott B. Raymond, Brian J. Bacskai and David A. Boas, "Comparison of Frequency Domain and Time Domain Fluorescence Lifetime Tomography,"Opt. Lett. 33, 470 (2008).

Jones PB, Rozkalne A, Meyer-Luehmann M, Spires-Jones TL,Makarova A, Kumar A.T.N., Berezovska O, Bacskai BJ, Hyman BT, "Two post-processing techniques for the elimination of background autofluorescence for FLIM,"J. of Biom. Opt., 13(1) 014008 (2008).

Anand T.N. Kumar, Scott B. Raymond, Gregory Boverman, David A. Boas and Brian J. Bacskai,"Time resolved fluorescence tomography based on lifetime contrast," Opt. Express 14 12255 (2006). LaTeX version

Phill B. Jones, Lauren Herl, Oksana Berezovska, Anand T.N. Kumar, Brian J. Bacskai and Bradley T. Hyman, "A time domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays," J. Biom. Opt. 11, 054024 (2006).

Anand T. N. Kumar, Jesse Skoch, Brian J Bacskai, David A Boas and Andrew K. Dunn,"Fluorescence Lifetime based tomography for turbid Media," Opt. Lett. 30, 3347 (2005).

Ye XO, Demidov A, Rosca F, Wang W, Kumar A, Ionascu D, Zhu LY, Barrick D, Wharton D, Champion PM, "Investigations of heme protein absorption line shapes, vibrational relaxation, and resonance Raman scattering on ultrafast time scales," J. Phys. Chem A, 107, 8156 (2003).

Florin Rosca, Anand. T. N. Kumar, D. Ionascu, X. Ye, A. A. Demidov, T. Sjodin, D. Wharton, D. Barrick, S. G. Sligar, T. Yonetani and P. M. Champion, "Investigations of Anharmonic Low Frequency Oscillations in Heme Proteins," J. Phys. Chem. A, 106, 3540 (2002).

Florin Rosca, Anand. T. N. Kumar, D. Ionascu, X. Ye, A. A. Demidov, T. Sjodin, D. Wharton, D. Barrick, and P. M. Champion, "Low frequency modes in heme proteins," B Chem Soc Jpn, 75, 1093 (2002).

Anand T. N. Kumar, Florin Rosca, Allan Widom and Paul M. Champion, "Investigations of Amplitude and Phase excitation profiles in Femtosecond Coherence Spectroscopy," J. Chem. Phys, 114, 701 (2001).

Anand T. N. Kumar, Florin Rosca, Allan Widom and Paul M. Champion, "Investigations of the ultrafast nuclear response induced by resonant and non-resonant laser pulses," J. Chem. Phys, 114, 6795 (2001).

Anand T. N. Kumar, Leyun Zhu, James F. Christian, Andrey A. Demidov and Paul M. Champion, "On the rate distribution analysis of kinetic data using the maximum entropy method: Applications to myoglobin relaxation on the nanosecond and femtosecond timescales," J. Phys. Chem. B, 105, 7847 (2001)

Florin Rosca, D. Ionascu, Anand T. N. Kumar, T. Sjodin, A. A. Demidov and Paul M. Champion, "Femtosecond coherence spectroscopy using spectrally selective differential photodetection," Chem. Phys. Lett. 337, 107 (2001).

Florin Rosca, Anand T. N. Kumar, Dan Ionascu, A. A. Demidov and P.M. Champion, "Wavelength selective modulation in femtosecond pump-probe spectroscopy and its applilcation to heme proteins," J. Chem. Phys. 114, 10884 (2001).

A. A. Demidov, X. Ye, F. Rosca, A. T. N. Kumar, Wang W, Zhu LY, P. M. Champion, "Investigations of ultrafast kinetics and dynamic absorption in heme- proteins," Biophys. J. 80(1), 1165 Part 2, (2001).

Florin Rosca, Anand T. N. Kumar, X. Ye, T. Sjodin, A. A. Demidov and P. M. Champion, "Investigations of coherent vibrational oscillations in Myoglobin," J. Phys. Chem. A, 104, 4280 (2000).

Christian JF, Unno M, Kumar ATN, Macdonald IDG, Benson DE, Sligar SG, Champion PM, "Investigation of putidaredoxin binding effects in oxy-P450cam using resonance Raman spectroscopy," BIOPHYS. J. 74 (2): A133-A133 Part 2, (1998).

A. J. Devaney, A. T. Friberg, A. T. N. Kumar and Emil Wolf, "Decrease of spatial coherence of light propagating in free space," Optics Letters 22, 1672 (1997).

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