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Mental Illness and Neuroscience Discovery (MIND) Insitute:
Boston Site

Principal Investigator:
Bruce Rosen, MD PhD, Massachusetts General Hospital

Current Project Period:
1/1/2004 - 12/31/2005 (renewed annually since 1999)

The Mental Illness and Neuroscience Discovery (MIND) Institute was founded to advance the understanding of mental illness and mental disorders through the use of modern brain imaging techniques. It consists of neuroimaging scientists and medical research institutions including the Harvard University, University of Minnesota, the University of New Mexico, and Los Alamos National Laboratory, and collaborates with other imaging centers such as The University of Iowa and the National Institutes of Health.

The MIND Institute aims to develop functional brain imaging techniques that optimize the spatial and temporal coverage, accuracy, and resolution of functional indices of brain activity and to apply these improved neuroimaging techniques to explore the mind and brain to enhance the lives of people with mental illness. A major goal of the MIND Institute is to foster interactions and collaborations within and across the participating sites to share advances and pool resources to address crucial questions about the mechanisms and treatment of mental illness.

The MIND Institute Boston Site involves investigators from MGH, Harvard Medical School, Massachusetts Mental Health Center, Brockton VA, and McLean Hospital. The program consists of three core basic and clinical science projects, each with several subprojects and a multi-site clinical consortium. Three cores support the activities of these projects.

For more information on any particular project, contact Julie Goodman.

Boston Area Schizophrenia Group

The Boston Schizophrenia Group (BSG) unites a group of independent schizophrenia researchers from three different clinical sites (MGH, Massachusetts Mental Health Center, Brockton VA) in the area for neuroimaging studies at the Athinoula A. Martinos Center. The labs involved share a common goal, to illuminate the neurological underpinnings of schizophrenia and related psychiatric illnesses.

Project Leader
Event-related fMRI study of transitive inference in Schizophrenia Stephan Heckers, MD, McLean Hospital
Use of linguistic and non-linguistic context in language comprehension in Schizophrenia Gina Kuperberg, MD, PhD, Dept. of Neurology, MGH
Spatiotemporal Dynamics of Context Processing in Schizophrenia Dara Manoach, PhD, Dept. of Radiology, MGH
Temporal Lobe Neocortical Abnormalities in Schizophrenia: A structural, functional and clinical perspective Robert McCarley, MD, Brockton VA Medical Center
Towards the Prevention of Schizophrenia: Neurobiological Studies of Families with Schizophrenia Larry Seidman, PhD, Massachusetts Mental Health Center
Auditory, Sensorimotor, and Language Area Mapping Using MEG with & without fMRI Contraints Steven Stufflebeam, MD, Dept of Radiology, MGH

Multimodal Imaging of Cognitive Processes

Project Leader
Contextual Predictions Facilitate Visual Cognition Moshe Bar, PhD, Dept Radiology, MGH
Visual responses to local stimuli Dalia Sharon, PhD
Comprehension of real-world events Caroline West, PhD

Basic Science Research

Project Leader
Spatial point spread function Joseph Mandeville, PhD
Figure-ground segmentation versus shape processing Wim Vanduffel, PhD
fMRI guided in-vivo tractography in monkeys David Tuch, PhD and Wim Vanduffel, PhD
Direct measurement of functional connectivity Wim Vanduffel, PhD

Computational Core

Project Leader
Data Analysis and Modeling Bruce Fischl, PhD

Consortium Projects

Project Leader
Clinical (Schizophrenia) Consortium Randy Gollub, MD, PhD
MEG Consortium Matti Hamalainen, PhD
Cytoarchitectonic MRI (cMRI) Consortium Christian Farrar, PhD
MR Spectroscopy (MRS) Consortium Bruce Jenkins, PhD and Larry Wald, PhD





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