Matthew S Rosen, PhD
Instructor in Radiology at Harvard Medical School
Assistant in Biomedical Engineering at Massachusetts General Hospital
Senior Research Scientist at Harvard University, Department of Physics
BS, Physics, Rensselaer Polytechnic Institute, Troy NY
PhD, Physics, The University of Michigan, Ann Arbor MI
Martinos Center for Biomedical Imaging
149 13th Street, Suite 2301
Charlestown, MA 02129
Phone: 617 643 8636
Fax: 617 496 7690
Location: CNY75-1205
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DESCRIPTION OF WORK / BIOSKETCH
My research interests focus on spin-polarized materials and their use as magnetic tracers for in vivo MRI, in solid, liquid, and gas phase. One aspect of this uses spin-exchange optical pumping techniques to produce long-lived polarizations of order unity in the spin 1/2 noble gas isotopes 3He and 129Xe.
We have developed and constructed a high-volume 3He polarizer and an open-access custom-made 6.5 mT low-field MRI (LFI) scanner, the combination of these technologies allowed our collaboration to image for the first time the orientation-dependent tomographic distribution of oxygen partial pressure in humans in vivo. I have an ongoing interest in orientation-variable imaging for studies of human cardiopulmonary physiology and we plan to correlate our MRI measurements of pulmonary perfusion and ventilation with those obtained from other imaging modalities such as PET imaging.
This biplanar electromagnet 6.5 mT LFI is at the core of the Low-field MRI and Hyperpolarized Media Laboratory at the Martinos Center that I established in 2010 to focus on the development of MRI-based applications of spin-polarized materials. Currently, I am PI of a DoD grant to develop tools and techniques for robust low-magnetic-field implementations of MRI focused on brain imaging. This applied research program builds on my group’s history of innovation in the development of novel methods of low-magnetic-field MRI and advanced MRI hardware as well as new opportunities provided by free-radical injury markers paired with in vivo DNP hyperpolarization. Without major innovation, high-field MRI instruments offer limited utility for imaging TBI in widely deployable contexts. We focus our research effort on the high-risk and critical challenges that must be solved to enable deployment of a transportable human-head MRI system applicable to TBI imaging in battlefield medical facilities. Our goal is to establish proof-of-principle of a suite of techniques and technologies to advise future development of a field-deployable device with high diagnostic impact.
My group has also been investigating efficient ways to create and manipulate nuclear-spin singlet states. This has evolved into a new method of quantum filtration. The transfer of spin polarization to the singlet is highly controllable through pulse sequence parameters, so that spectral contrast can be achieved between molecules with very similar structures. This technique is named SUCCESS, "Suppression of Undesired Chemicals using Contrast-Enhancing Singlet States."
LINKS
The Low-field Imaging Laboratory at Martinos
Popular Science article about Dr. Rosen's Low Field Imager
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