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Yaotang Wu, PhD
Assistant Professor in Radiology at Harvard Medical School
Visiting Scientist at Massachusetts General Hospital
PhD, MIT
Rm 030.3 Enders Building
300 Longwood Ave, Children's Hospital
Boston, MA 02115
Phone: 617-919-2060
Fax: 617-726-7422
Location: Children’s Hosp
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DESCRIPTION OF WORK / BIOSKETCH
I am committed to the study of bone mineralization in two basic areas: (1) NMR imaging (MRI), which yields the spatial properties of bone as a tissue based on the spatial variation of the NMR signals of bone; and (2) NMR spectroscopy, which provides an analysis of the properties of bone as a material.
Solid state MRI has the potential to measure the 3D volumetric density of bone mineral and matrix fraction factor. Combining these two measurements yields the degree of bone mineralization (DM), and will enable us to detect the compositional changes in bone substance such as osteomalacia, which can currently be obtained only by an invasive bone biopsy. One of the advantages of Solid State NMR Spectroscopy study of bone mineral is that there is general no need of any conventional chemical treatment to prepare the samples. Special NMR techniques can suppress uninteresting dominant signals and reveal the desired features which can not be seen by other techniques.
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