Scott B Raymond|
Medical Student at The Harvard-MIT Division of Health Sciences and Technology
Department of HST, MIT
PhD, Biophysics, Medical Engineering and Medical Physics, Harvard University, The Harvard-MIT Division of Health Sciences and Technology
114 16th St Rm 2285
Charlestown, MA 02129
DESCRIPTION OF WORK / BIOSKETCH
Alzheimer's disease (AD) is a neurodegenerative disorder that afflicts millions worldwide, is difficult to diagnose, and has no cure. My primary interest is to develop near-infrared fluorescence (NIRF) technology to image amyloid-beta (ABeta), a characteristic protein that accumulates in the AD brain and serves as a biomarker of disease. Advances in positron emission tomography (PET) have enabled clinical ABeta imaging, but the high cost and limited availability of PET prohibit widespread use. We envision that NIRF imaging would be far less expensive and easily exportable. As a pre-clinical step, we are developing small animal NIRF imaging for quantifying ABeta in transgenic mouse models of AD.
A robust, non-invasive small animal imaging technique would significantly accelerate pre-clinical drug trials, aid basic AD research in mouse models, and ultimately, might be translated to the clinic for human imaging and diagnosis.
Alzheimer's Imaging Lab