Multi-Modal 5-Day Intensive (NEW!)
Robert L. Savoy, Ph.D., Director of fMRI Education
Bruce R. Rosen, M.D., Ph.D., Director of the MGH/MIT/HMS Martinos Center
Active Introduction to EEG/MEG, fMRI, High-Resolution MR and fMRI, NIRS, PET, and TMS
Program Dates: December 13-17, 2010
Program Code: 2010Dec13
This 5-day program will run Monday-Friday. The program is an adaptation of the two-week,
government-sponsored program on multi-modal imaging held each year in the spring, at the Martinos Center for Biomedical Imaging. (For details
on that program, see Multi-Modal Short Course.) However, unlike that program (which
requires competitive applications and notification by March 15 of the program year about offers of acceptance), the present program
is being offered on a "first come, first served" basis. Total enrollment will be limited.
This program will be organized as indicated in the tentative schedule, below. For the first three days, each
1/2 day will be devoted to one imaging modality as used in the context of functional brain research.
The content will focus on the underlying
physics, experimental design, data analysis, and a few of the currently cutting edge applications
of each technology. A special emphasis will be made to show when and how the information
from different modalities can complement each other, and facilitate additional conclusions not
obtainable by one modality alone. In addition to classroom lectures,
participants will engage in experimental design workshops, tours of the
relevant equipment, and demonstrations of the equipment for each modality.
Students will receive a firm grounding in the fundamentals of each modality. This will
include the basic physics of the technology, the biology and biophysics underlying the technology;
data analysis as it is done specifically with respect to the basic technologies, and also as it is
implemented when trying to integrate the various structural and functional data obtained from each modality.
A special emphasis of the course will be the design, implementation, and execution
of perceptual and/or cognitive experiments by the participants. Participants
will break into small groups to design their own experiments. These exercises will be an ongoing activity during the program,
and will be facilitated by evening workshops. The results of the group designs will be presented and discussed on the
final day of the workshop.
The modalities include:
High-Resolution MRI (Magnetic Resonance Imaging) with an empahsis on the possibilities engendered by imaging at 7Tesla
and beyond, including the associated dramatic increase in spatial resolution which can, in some applications, resolve excitations within cortical
layers. Diffusion Tensor Imaging (DTI), Diffusion Spectrum Imaging (DSI), and MR Spectroscopy (MRS) will be mentioned at various
times during the program.
fMRI (Functional Magnetic Resonance Imaging) with an emphasis on the ways in which fMRI data can be integrated with data from other
modalities. Note: Because fMRI is by far the most widely used functional brain imaging modality, it will be assumed
that participants have some familiarity with it. A review, in 1/2 day, will be included, but the emphasis will be on
the ways in which fMRI combines with other modalities, rather than being the focus of attention by itself. (For a
longer and more substantial introduction to fMRI, please see fMRIVFP.)
PET (Positron Emission Tomography), and its new integration with MRI, as used in equipment that can collect both
PET and MRI/fMRI data simultaneously to facilitate structural and functional studies. There will be a discussion of the range of
available ligands for binding, and the associated implications for cognitive and clinical research, with an emphasis on
implications for the future of imaging-based psychiatric diagnosis.
NIRS (Near Infrared Spectroscopy) with an emphasis on the flexibility introduced by having relatively
inexpensive and portable equipment for monitoring cerebral blood. Recent advances made possible via the use of NIRS data
to enhance noise reduction in fMRI and other modalities will be discussed.
EEG/MEG (Electro- and Magneto- Encephalography) including the simultaneous collection of EEG data with
fMRI data, even at 7 Tesla. Because of the inherent complementarity in terms of spatial and temporal resolution between
EEG/MEG and fMRI/PET, there will be a particularly rich discussion of integrating these data accross modalities.
TMS (Transcranial Magnetic Stimulation) is the only technology currently available for facilitating or
disrupting known axonal pathways in the service of elucidating the causal relationships within functional brain imaging.
Demonstrations will be conducted, and the use of TMS to elicidate existing cortical connections will be emphasized in the
applications. In addition, the crucial role of real-time guidance using previously collected MRI and fMRI data will be
discussed and demonstrated.
- Morning: MRI
- Afternoon: fMRI (and General Linear Model for Data Analysis)
- Evening: Social Dinner and Introduction to Design Workshop
- Morning: EEG/MEG
- Afternoon: NIRS
- Evening: free!
- Morning: TMS
- Afternoon: PET
- Evening: Working Dinner and Design Workshop
- Morning: Multi-Modality Integration and Data Analysis
- Afternoon: Multi-Modality Integration and Applications
- Evening: (Sushi & Karaoke in Kenmore Square?)
- Morning & Early Afternoon: Presentation of Class Designs; General Discussion
MINIMUM NUMBER OF PARTICIPANTS HAS BEEN MET
Because this is a new program, we have been uncertain about the level of interest. However, responses to
our initial announcements has been encouraging. In the interest of making planning possible, especially for
oversees visitors, we have decided to DEFINITELY hold the
program this year, during the specified period of December 13-17, 2010. We encourage out-of-town visitors to secure
accommodation, and to use the information given at the bottom of this page.
The core faculty is drawn from the staff of the Athinoula A. Martinos Center
(of the Massachusetts General Hospital and Massachusetts Institute of Technology) and
affiliated faculty from Harvard University, Boston University, McLean Hospital and other institutions. Budget permitting,
additional outside speakers will be invited to participate.
Please use our REGISTRATION FORM to register.
Enrollment is limited; early registration is recommended.
FUNDING and FEEs
This program, like the fMRI Visiting Fellowship Program, is sponsored in part by the Athinoula A Martinos Center for
Biomedical Imaging, which provides space, various imaging resources, and most of the faculty. The remainder of the funding
is provided by participant tuition. This tuition will be: US$1500 for regular participants and US$1000 for graduate students.
(Post-doctoral trainees who are unable to get institutional or grant funding—and must therefore pay the tuition
out-of-pocket—are eligible for a discounted rate of US$1250.)
Information regarding recommended and alternative accommodations can be found at: Accommodation Information.