ANIMAL RESEARCH RULES AND REGULATIONS

All research done at MGH is subject to the rules and regulations of the Center for Comparative Medicine (CCM). They are the controlling authority at MGH for all matters that pertain to the care and use of laboratory animals. The Martinos Center’s policy is to follow all CCM rules and regulations to the letter. Their web site is:

http://intranet.massgeneral.org/ccm/

This is an intranet connection and can only be accessed by connecting to the MGH intranet.

All research done at the Martinos Center must first be approved by the CCM. They have appointed the Subcommittee on Research Animal Care (SRAC) to act as their instrument in monitoring all research at MGH. SRAC serves as the Institutional Animal Care and Use Committee (IACUC) for the Massachusetts General Hospital (MGH) and The Shriners Hospital for Children (SCH). Their website is:

http://is.partners.org/aniweb/index.htm

All investigators should visit this site and acquaint themselves with the rules and regulations of the SRAC committee. There is a synopsis of what investigators need to know that can be accessed by clicking on the “Regulatory & Guidance Documents” link of the above web address.

All investigators who wish to do research at MGH must first submit an application for approval with the Subcommittee on Research Animal Care. If approved, the following documents must be submitted to Karen Dervin before an imaging account can be opened and imaging of animals commences.

  • Electronic copy of the complete SRAC application (with all addendums) that was submitted to the SRAC committee
  • Electronic copy of the most recent SRAC approval letter for the protocol 
  • Electronic copy of any protocol amendments and amendment approval letters

SRAC approvals are specific for species, number of animals, animal preparation, surgical intervention drug administration, and anesthesia protocols as well as methods of euthanasia and post surgical care. Investigators are only allowed to use the number and species of animals that they have been approved to use by the SRAC committee and can only perform procedures that have been approved. Any changes that an investigator may want to institute must first be submitted to the SRAC committee for further approval before such changes are implemented.

Furthermore SRAC approvals are not transferable and are only valid for the duration indicated on the approval letter. In short, research that involves the use of laboratory animals can only be conducted in the manner specifically approved by the SRAC committee.

All investigators and staff who operate any imaging system while conducting animal research must have with them a copy of their SRAC approval letter.

All investigators who image animal tissue phantoms need to submit to the SRAC office a “Request for Animal Tissue Products.” A SRAC letter of approval to use animal tissue is required when opening an imaging account or requesting time on the scanners. Information can be found at:

http://is.partners.org/aniweb/animtiss.htm

This is an intranet connection that requires access to the MGH intranet. There is a link at this site to download the proper form.

All Martinos employees who need access to the imaging bays must first take the MRI safety course. Contact Mary Foley for more information. mtf@nmr.mgh.harvard.edu

All Martinos Surgery Rooms are restricted areas and anyone who needs access to them must take the Martinos Surgery Room Orientation. Contact John Moore for further information. john@nmr.mgh.harvard.edu

All animal transportation within an MGH animal facility, between MGH animal facilities, and to and from MGH will be in compliance with federal and state laws and regulations and current accreditation standards.

Transportation of research animals within MGH buildings must be done in a discreet and protected manner, to minimize contact between the animal and non-research staff, patients, and the public. All animals must be completely enclosed in a container or covered while on a transport device approved by the Director of the Center for Comparative Medicine (CCM) or his/her designee. Larger species (e.g., dogs, livestock, nonhuman primates) and smaller yet possibly vocal species (e.g., guinea pigs, rabbits) must be transported in a manner that minimizes apparent sound or motion and strong consideration should be given to using sedation to facilitate transport within MGH buildings.

Transportation of research animals between the Boston and Charlestown campuses and to and from other destinations outside MGH must be approved by the SRAC and CCM and performed with an approved vehicle or by another approved party. Such approval will be granted on a protocol basis rather than for each trip. A request for CCM animal transportation services is made to the CCM Animal Transport Coordinator. In cases involving transport for frequent training or imaging sessions of larger species, research staff may perform such transportation in a CCM vehicle only after proper training is provided and the approval of the Director of CCM or his/her designee has been obtained.

Contact the Webmaster