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I am working to identify the trait genetic and neurobiological mechanisms contributing to the onset of psychological illnesses such as Major Depressive Disorder (MDD). Within this framework I have focused on the relationship between mood, affect, and the processes that allow for the adaptive optimization of task performance. As a post-doctoral fellow I am interested in expanding this line of research to incorporate studies of the molecular genetic basis of individual differences in affect and cognition.

Avram is transitioning to a faculty position in the Department of Psychology at Yale University. His lab can be found here.


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Holmes, A.J., Lee P.H., Hollinshead, M., Bakst, L., Roffman, J.L., Smoller, J.W., Buckner, R.L. (2012) Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk. Journal of Neuroscience 32(50), 18087-18100. [medline abstract]

Holmes, A.J., Pizzagalli, D. (2010) Effects of task-relevant incentives on the electrophysiological
correlates of error processing in Major Depressive Disorder. Cogn Affect Behav Neurosci;
10(1):119-28.
[medline abstract]

Holmes, A.J., Bogdan, R., Pizzagalli, D. (2010) Serotonin transporter genotype and action monitoring
dysfunction: A possible substrate underlying increased vulnerability to depression.
Neuropsychopharmacology; 35(5):1186-97.
[medline abstract]

Holmes, A.J., Pizzagalli, D.A. (2008) Response Conflict and Frontocingulate Dysfunction in
Unmedicated Participants with Major Depression. Neuropsychologia; 46(12):2904-13.
[medline abstract]

Holmes, A.J., Pizzagalli, D.A. (2008) Spatiotemporal Dynamics of Action Monitoring Dysfunctions in
Major Depressive Disorder. Arch Gen Psychiatry; 65(2)-179-88.
[medline abstract]