I am working to identify
the trait genetic and neurobiological mechanisms
contributing
to the onset of psychological illnesses such as Major
Depressive Disorder (MDD).
Within this framework I have focused on the relationship
between mood, affect, and the
processes that allow for the adaptive optimization of task
performance. As a
post-doctoral fellow I am interested in expanding this line
of research to incorporate
studies of the molecular genetic basis of individual
differences in affect and cognition.
Holmes,
A.J., Lee P.H., Hollinshead, M.,
Bakst, L., Roffman, J.L., Smoller, J.W., Buckner, R.L. (2012) Individual
differences in amygdala-medial prefrontal anatomy link negative affect, impaired social
functioning, and polygenic depression risk. Journal of Neuroscience 32(50), 18087-18100.
[medline abstract] Holmes,
A.J., Pizzagalli,
D. (2010) Effects of task-relevant incentives on the
electrophysiological
correlates of error processing in Major Depressive
Disorder. Cogn Affect Behav Neurosci;
10(1):119-28. [medline abstract]
Holmes,
A.J., Bogdan, R.,
Pizzagalli, D. (2010) Serotonin transporter genotype and
action monitoring
dysfunction: A possible substrate underlying increased
vulnerability to depression.
Neuropsychopharmacology; 35(5):1186-97. [medline abstract]
Holmes,
A.J., Pizzagalli,
D.A. (2008) Response Conflict and Frontocingulate
Dysfunction in
Unmedicated Participants with Major Depression.
Neuropsychologia; 46(12):2904-13. [medline abstract]
Holmes,
A.J., Pizzagalli,
D.A. (2008) Spatiotemporal Dynamics of Action Monitoring
Dysfunctions in
Major Depressive Disorder. Arch Gen Psychiatry;
65(2)-179-88. [medline abstract]
