Hesheng Liu is an Assistant Professor at Harvard Medical School and the Martinos Center for Biomedical Imaging, Massachusetts General Hospital. He also serves as the Director of The Laboratory for the Study of the Brain Basis of Individual Differences at MGH.His research seeks to understand what makes individual brain's distinct. Although human brains share common structural and functional properties, considerable differences exist between people. A major goal of his work is to improve surgical planning for epilepsy and brain tumor patients, which requires precise mapping of the brain systems in individual patients. Another goal is to find individual differences that mark psychiatric disorders such as schizophrenia. Using modern imaging and computational technologies, he aims to develop reliable signatures of psychiatric illness that can provide increased statistical power for investigating genetic associations and determining risk of illness. To facilitate these investigations, he has built a platform to merge information within an individual from multiple imaging modalities including anatomical and functional MRI, MEG/EEG, and intracranial ECoG.



Mueller, S., Wang, D., Fox, M.D., Sepulcre, J., Sabuncu, M.R., Shafee, R., Lu, J., & Liu, H.. (in press) Individual variability in functional connectivity architecture of the human brain. Neuron.

Wang, D., Buckner, R.L, & Liu, H. (2013) Cerebellar asymmetry and its relation to cerebral asymmetry estimated by intrinsic functional connectivity. Journal of Neurophysiology, 109(1):46-57.
[medline abstract]

Lu, J.*, Liu, H.*, Zhang, M., Wang, D., Cao, Y., Ma, Q., Rong, D., Wang, X., Buckner, R.L., & Li, K. (2011) Focal pontine lesions provide evidence that intrinsic functional connectivity reflects polysynaptic anatomical pathways. Journal of Neuroscience, 31(42):15065-71. [medline abstract]

Liu, H., Stufflebeam, S.M., Sepulcre, J., Hedden, T., & Buckner, R.L. (2009) Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors. Proceedings of the National Academy of Sciences, U.S.A., 106(48):20499-503. [medline abstract]

Liu, H., Agam, Y., Madsen, J.R., Krieman, G. (2009) Timing, timing, timing: Fast decoding of object information from intracranial field potentials in human visual cortex. Neuron, 62(2):281-90. [medline abstract]