I am interested in exploring how brain activity, and specifically activity in the medial temporal lobe and its associated cortical network, anticipates future events.  Recent studies in rats show that medial temporal lobe activity anticipates future events during navigation (preplay).  Using function MRI, I will test in humans whether brain activity, including medial temporal lobe activity, anticipates future events during navigation through a virtual environment.  Further, I will test whether that activity predicts behavioral outcome within individuals and also if anticipatory activity predicts performance across individuals.


Shrager, Y., Kirwan, C.B. & Squire, L.R. (2008). Activity in both hippocampus and perirhinal cortex predicts the memory strength of subsequently remembered information. Neuron, 59(4): 547 - 53. [medline abstract]

Shrager, Y., Kirwan, C.B. & Squire, L.R. (2008). The neural basis of the cognitive map: path integration does not require hippocampus or entorhinal cortex.
Proc Natl Acad Sci U S A, 105(33): 12034 - 8. [medline abstract]

Shrager, Y., Levy, D.A., Hopkins, R.O. & Squire, L.R. (2008). Working memory and the organization of brain systems.
Journal of Neuroscience, 28(18): 4818 - 22. [medline abstract]

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