squiqally

The traditional approach to studying brain function is to measure physiological responses to controlled sensory, motor, and cognitive paradigms. However, most of the brain’s enormous energy consumption is devoted to ongoing neuronal signaling that is not clearly associated with any particular input or output. In search of an understanding of this intrinsic neuronal signaling my collaborators and I are studying spontaneous fluctuations (“noise”) in the electroencephalogram (EEG) and blood oxygen level dependent (BOLD) signal. Our results demonstrate that cortical representations previously associated with sensory, motor, and cognitive phenomena are coherently active in the absence of normal perception or overt behavior.

squiqally

Vincent J.L., Patel G.H., Fox M.D., Snyder A.Z., Baker J.T., Van Essen D.C., Zempel J.M., Snyder L.H. Corbetta M., Raichle M.E. (2007) Intrinsic functional architecture in the anesthetized monkey brain. Nature, 447:83-6. [medline abstract]

Vincent J.L., Larson-Prior L.J., Zempel J.M., Snyder A.Z. (2007) Moving GLM ballistocardiogram artifacts reduction for EEG data acquired simultaneously with fMRI. Clinical Neurophysiology, 118:981-98. [medline abstract]

HE B.J., Snyder A.Z.,
Vincent J.L., Epstein A., Shulman G.L., Corbetta M. (2007) Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect. Neuron, 53:905-18. [medline abstract]

Buckner R.L. and
Vincent J.L. (2007) Unrest at rest: Default activity and spontaneous network correlations. Neuroimage, 37:1091-6. [medline abstract]

Vincent J.L., Snyder A.Z., Fox M.D., Shannon B.J., Andrews J.R., Raichle M.E., and Buckner R.L. (2006) Coherent Spontaneous Activity Identifies a Hippocampal-Parietal Mnemonic Network. Journal of Neurophysiology, 6:3517-3531. [medline abstract]

Fox M.D., Corbetta, M., Snyder A.Z.,
Vincent J.L., Raichle M.E. (2006) Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proceedings of the National Academy of Sciences USA; 103(26): 10046-51. [medline abstract]

Fox M.D., Snyder A.Z.,
Vincent J.L., Corbetta M., Van Essen D.C., Raichle M.E. (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of Sciences USA; 102(27): 9673-8. [medline abstract]

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