The traditional approach to
studying brain function is to measure physiological
responses to controlled sensory, motor, and cognitive
paradigms. However, most of the brain’s enormous energy
consumption is devoted to ongoing neuronal signaling that
is not clearly associated with any particular input or
output. In search of an understanding of this intrinsic
neuronal signaling my collaborators and I are studying
spontaneous fluctuations (“noise”) in the
electroencephalogram (EEG) and blood oxygen level dependent
(BOLD) signal. Our results demonstrate that cortical
representations previously associated with sensory, motor,
and cognitive phenomena are coherently active in the
absence of normal perception or overt behavior.
Vincent
J.L., Patel G.H.,
Fox M.D., Snyder A.Z., Baker J.T., Van Essen D.C., Zempel
J.M., Snyder L.H. Corbetta M., Raichle M.E. (2007)
Intrinsic functional architecture in the anesthetized
monkey brain. Nature, 447:83-6. [medline abstract]
Vincent
J.L., Larson-Prior
L.J., Zempel J.M., Snyder A.Z. (2007) Moving GLM
ballistocardiogram artifacts reduction for EEG data
acquired simultaneously with fMRI. Clinical
Neurophysiology, 118:981-98. [medline abstract]
HE B.J., Snyder A.Z., Vincent J.L., Epstein A., Shulman G.L., Corbetta M.
(2007) Breakdown of functional connectivity in
frontoparietal networks underlies behavioral deficits in
spatial neglect. Neuron, 53:905-18. [medline abstract]
Buckner R.L. and Vincent J.L. (2007) Unrest at rest: Default activity
and spontaneous network correlations. Neuroimage,
37:1091-6. [medline abstract]
Vincent
J.L., Snyder A.Z.,
Fox M.D., Shannon B.J., Andrews J.R., Raichle M.E., and
Buckner R.L. (2006) Coherent Spontaneous Activity
Identifies a Hippocampal-Parietal Mnemonic Network. Journal
of Neurophysiology, 6:3517-3531. [medline abstract]
Fox M.D., Corbetta, M., Snyder A.Z., Vincent J.L., Raichle M.E. (2006) Spontaneous neuronal
activity distinguishes human dorsal and ventral attention
systems. Proceedings of the National Academy of Sciences
USA; 103(26): 10046-51. [medline abstract]
Fox M.D., Snyder A.Z., Vincent J.L., Corbetta M., Van Essen D.C., Raichle
M.E. (2005) The human brain is intrinsically organized into
dynamic, anticorrelated functional networks. Proceedings of
the National Academy of Sciences USA; 102(27):
9673-8. [medline abstract]
