Neuroimage. 2013 Aug 1;76:57-69 doi: 10.1016/j.neuroimage.2013.02.068. 2013 Mar 23.

FMRI analysis of contrast polarity in face-selective cortex in humans and monkeys

Yue X, Nasr S, Devaney KJ, Holt DJ, Tootell RB.

Abstract

Recognition is strongly impaired when the normal contrast polarity of faces is reversed. For instance, otherwise-familiar faces become very difficult to recognize when viewed as photographic negatives. Here, we used fMRI to demonstrate related properties in visual cortex: 1) fMRI responses in the human Fusiform Face Area (FFA) decreased strongly (26%) to contrast-reversed faces across a wide range of contrast levels (5.3-100% RMS contrast), in all subjects tested. In a whole brain analysis, this contrast polarity bias was largely confined to the Fusiform Face Area (FFA; p

PMID: 23518007