J Cereb Blood Flow Metab. 2013 Sep 12. doi: 10.1038/jcbfm.2013.158. [Epub ahead of print]

Multiple-capillary measurement of RBC speed, flux, and density with optical coherence tomography

Lee J, Wu W, Lesage F, Boas DA.

Abstract

As capillaries exhibit heterogeneous and fluctuating dynamics even during baseline, a technique measuring red blood cell (RBC) speed and flux over many capillaries at the same time is needed. Here, we report that optical coherence tomography can capture individual RBC passage simultaneously over many capillaries located at different depths. Further, we demonstrate the ability to quantify RBC speed, flux, and linear density. This technique will provide a means to monitor microvascular flow dynamics over many capillaries at different depths at the same time.Journal of Cerebral Blood Flow & Metabolism advance online publication, 11 September 2013; doi:10.1038/jcbfm.2013.158.

PMID: 24022621