Advanced Pre-Clinical Imaging for Basic and Pharmaceutical Research

We will offer this course again in 2015. Please check back for official dates.

149 Thirteenth Street, Charlestown, MA

REGISTRATION FORM
ACCOMMODATIONS

Pre-clinical studies can play a vital role in testing potential therapies, aiding in drug discovery and helping to increase the range of potential experimental manipulations that can be performed to address any number of questions. This course will provide an overview of the problems and techniques that can be used for pre-clinical imaging studies targeted towards pharmacology and the pharmaceutical industry. The course is targeted towards those who would like to better understand the issues and novel imaging technologies that can be applied to help solve a wide-range of important problems covering many different applications. The course is targeted towards an audience with some general understanding of imaging technologies and what problems can be addressed with these tools.

Technologies to be covered: Due to the two-day format we will only be covering Magnetic Resonance Imaging (MRI) and  Positron Emission Tomography (PET).

AGENDA:

Day 1

8:00 – 8:15 Introduction and Overview: Bruce G. Jenkins, PhD 
8:15 – 9:00 Overview of Regulatory, Animal Handling and Anesthesia Issues: Shannon Sloboda
9:30 – 9:45 The Effects of Common Anesthetics on Neuroreceptors and Flow-Metabolism Coupling: John Marota
9:45 – 10:00 Break
10:00 – 11:00 Hemodynamics, Metabolism and Neurovascular Coupling: Bruce G. Jenkins
12:00 – 1:00 Lunch
1:00 – 2:00 PET Data Collection Strategies: Counting Statistics, Signal to Noise, Resolution: Dr. Jacob Hooker
2:00 – 3:00 PET in Small Animal Disease Models: Anna-Liisa Brownell
3:00 – 3:15 Break
3:15 – 4:15 Combined PET/MRI and Molecular Imaging: Dr. Peter Caravan
4:15 – 4:45 Tour of facilities with special emphasis on animal imaging
   

Day 2

8:15 – 9:15 MRI Data Collection Strategies in Animals: MR Physics and Pulse Sequences: Dr. Joe Mandeville
9:15 – 10:00 Independent Components Analysis of the Resting State: Dr. Lisa Nickerson
9:45 – 10:30 Multi-model Imaging: EEG/MEG/NIRS
10:00 – 10:15 Break
10:15 – 11:15 Drug Discovery using f/phMRI: Dr. Adam J. Schwartz
11:15 – 12:15 General Linear Modeling: Dr. Joe Mandeville
12:15 – 1:15 Lunch
1:15 – 2:00 Effect Sizes, Power Calculations and Study Design: Dr. Bruce Jenkins
2:00 – 2:30 MRI and MRS Studies in Transgenic Animals Models of Neurodegenerative Illness: Dr. Ji-Kyung Choi
2:30 – 3:00 Pharmacologic MRI of Parkinson’s Disease Models: Dr. Iris Chen
3:00 – 3:15 Break
3:15 – 4:15 Small Animal Imaging in Oncologic Applications: Dr. Anna Moore
4:15 – 5:00 Round Table Discussion on Pre-Clinical Imaging for Drug Discovery:  Drs. Caravan, Schwartz and Jenkins

 

COURSE FACULTY:

Bruce G. Jenkins, PhD (Organizer)
A.A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital and Harvard Medical School
 
Dr. Anna-Liisa Brownell
Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital and Harvard Medical School
 
Dr. Yin-Chin Iris Chen
A.A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital and Harvard Medical School
 
Dr. Ji-Kyung Choi
A.A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital and Harvard Medical School
 
Dr. Joseph Mandeville
Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital and Harvard Medical School.
 
Dr. John Marota
Massachusetts General Hospital, Department of Anesthesiology. 
 
Dr. Anna Moore
A.A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital and Harvard Medical School
 
Dr. Lisa Nickerson
McLean Hospital and Harvard Medical School
 
Dr. Adam J. Schwartz
Eli Lilly Pharmaceuticals and Indiana University.
 
Shannon M Sleboda CVT RLAT SRA, Program Manager-Critical care Services
Massachusetts General Hospital, Center For Comparative Medicine 
 
Dr. Wim Van Duffel
Professor and Director of the Research Group in Neurophysiology, University of Leuven, Leuven, Belgium
 

REGISTRATION:

The fee for the two-day course is $500.

Make checks payable to:
Massachusetts General Hospital
Please include your name on the check

Send to:
Stacey Ladieu
Athinoula A. Martinos Center for Biomedical Imaging
149 Thirteenth St Room 2301
Charlestown, MA 02129

Course fees are refundable up to 30 days prior to the course.