Larry Seidman, PhD
Professor of Psychology, Harvard Medical School
Director, Commonwealth Research Center
Research Associate in Psychiatary, Massachusetts General Hospital
PhD Clinical-Community Psychology, Boston University, 1980
Harvard Medical School Department of Psychiatry
25 Shattuck Street
Boston, MA 02115 USA
General Contact Information
The overall goals of the laboratory are to further understand the etiology and cognitive pathophysiology of neurodevelopmental disorders in psychiatry, in particular, schizophrenia, bipolar psychosis,
attention-deficit/hyperactivity disorder (ADHD) and dyslexia. The lab has a developmental focus, studying the contributions of genetic and environmental factors (such as prenatal and perinatal events) to these
disorders and their neurobiological phenotypes. We focus largely on large-scale, population-based family studies to evaluate structural and functional brain abnormalities in persons with schizophrenia and
spectrum disorders, bipolar disorders, and ADHD and in genetically related subjects (offspring, siblings, parents) at different developmental epochs, ranging from early teen years to late adult life. Measures of brain function and structure are linked to measures of symptomatology, neurocognition, prenatal and perinatal events, genetic vulnerability, and gonadal steroid hormones (in collaboration with Dr. Jill Goldstein). Age (particularly adolescence) and sex effects on brain function and structure are an important focus of
study. We utilize morphometric tools from the MGH Center for Morphometric Analysis (in collaboration with Dave Kennedy and Nikos Makris), including general segmentation, cortical parcellation, cerebellar parcellation, and diffusion tensor imaging (DTI).
Functional measures include tasks of working memory (N-back and CPT variants), declarative memory, inhibitory processes, timing, and phonological processing.