Eva-Maria Ratai, PhD

Professional Information

Experience: 

Assistant Professor in Radiology, Harvard Medical School
Assistant in Neuroscience, Massachusetts General Hospital

Education: 

PhD Physical Chemistry, Westfaelische Wilhelms University, Muenster, Germany, 2000

Position: 
Martinos Faculty

Contact

Mailing Address

149 Thirteenth Street
Charlestown, MA 02129

General Contact Information

Phone: 
617-726-1744
Location: 
149-2318

Biosketch

The goals of my research are to advance the understanding of central nervous system (CNS) diseases through the application of advanced neuroimaging techniques, specifically, magnetic resonance imaging (MRI) and MR spectroscopy MRS.
Currently, am active in a number of research projects related to brain tumors, hypoxic ischemic injury in neonates, neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), and neuro-developmental disorders such as autism or OCD.

 

Publications:




  1. Wu W, Babb J, Tal A, Kirov I, George A, Ratai EM, Gonzalez R, Gonen O. Early glial activation precedes neurodegeneration in the cerebral cortex after SIV infection: A 3D, multivoxel proton magnetic resonance spectroscopy study. HIV Med. 2015 Feb 17.

    View in: PubMed


  2. Campbell JH, Ratai EM, Autissier P, Nolan DJ, Tse S, Miller AD, Gonzlez RG, Salemi M, Burdo TH, Williams KC. Anti-a4 Antibody Treatment Blocks Virus Traffic to the Brain and Gut Early, and Stabilizes CNS Injury Late in Infection. PLoS Pathog. 2014 Dec; 10(12):e1004533.

    View in: PubMed


  3. Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Diner A, Dydak U, Emir UE, Frahm J, Gonzlez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hppi PS, Hurd RE. Clinical Proton MR Spectroscopy in Central Nervous System Disorders. Radiology. 2014 Mar; 270(3):658-79.

    View in: PubMed


  4. Wu WE, Tal A, Zhang K, Babb JS, Ratai EM, Gonzlez RG, Gonen O. Structure-specific glial response in a macaque model of neuroAIDS: multivoxel proton magnetic resonance spectroscopic imaging at 3 Tesla. AIDS. 2013 Oct 23; 27(16):2519-28.

    View in: PubMed


  5. Caruso PA, Johnson J, Thibert R, Rapalino O, Rincon S, Ratai EM. The use of magnetic resonance spectroscopy in the evaluation of epilepsy. Neuroimaging Clin N Am. 2013 Aug; 23(3):407-24.

    View in: PubMed


  6. Ratai EM, Zhang Z, Snyder BS, Boxerman JL, Safriel Y, McKinstry RC, Bokstein F, Gilbert MR, Sorensen AG, Barboriak DP. Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. Neuro Oncol. 2013 Jul; 15(7):936-44.

    View in: PubMed


  7. Cohen-Adad J, Zhao W, Keil B, Ratai EM, Triantafyllou C, Lawson R, Dheel C, Wald LL, Rosen BR, Cudkowicz M, Atassi N. 7-T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis. Muscle Nerve. 2013 May; 47(5):760-2.

    View in: PubMed


  8. Wu WE, Tal A, Kirov II, Rusinek H, Charytonowicz D, Babb JS, Ratai EM, Gilberto Gonzalez R, Gonen O. Global gray and white matter metabolic changes after simian immunodeficiency virus infection in CD8-depleted rhesus macaques: proton MRS imaging at 3 T. NMR Biomed. 2013 Apr; 26(4):480-8.

    View in: PubMed


  9. Westmoreland SV, Annamalai L, Lentz MR, Ratai EM, Assaf B, Boisvert K, Huynh T, Vallender EJ, Miller GM, Madras BK, Gonzalez RG. Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques. J Neurovirol. 2011 Oct; 17(5):455-68.

    View in: PubMed


  10. Kim H, Catana C, Ratai EM, Andronesi OC, Jennings DL, Batchelor TT, Jain RK, Sorensen AG. Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma. Cancer Res. 2011 Jun 1; 71(11):3745-52.

    View in: PubMed


  11. Campbell JH, Burdo TH, Autissier P, Bombardier JP, Westmoreland SV, Soulas C, Gonzlez RG, Ratai EM, Williams KC. Minocycline inhibition of monocyte activation correlates with neuronal protection in SIV neuroAIDS. PLoS One. 2011; 6(4):e18688.

    View in: PubMed


  12. Ratai EM, Pilkenton S, He J, Fell R, Bombardier JP, Joo CG, Lentz MR, Kim WK, Burdo TH, Autissier P, Annamalai L, Curran E, O'Neil SP, Westmoreland SV, Williams KC, Masliah E, Gilberto Gonzlez R. CD8+ lymphocyte depletion without SIV infection does not produce metabolic changes or pathological abnormalities in the rhesus macaque brain. J Med Primatol. 2011 Oct; 40(5):300-9.

    View in: PubMed


  13. Ratai EM, Annamalai L, Burdo T, Joo CG, Bombardier JP, Fell R, Hakimelahi R, He J, Lentz MR, Campbell J, Curran E, Halpern EF, Masliah E, Westmoreland SV, Williams KC, Gonzlez RG. Brain creatine elevation and N-Acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of neuroAIDS. Magn Reson Med. 2011 Sep; 66(3):625-34.

    View in: PubMed


  14. Wu WE, Kirov II, Zhang K, Babb JS, Joo CG, Ratai EM, Gonzlez RG, Gonen O. Cross-sectional and longitudinal reproducibility of rhesus macaque brain metabolites: a proton MR spectroscopy study at 3 T. Magn Reson Med. 2011 Jun; 65(6):1522-31.

    View in: PubMed


  15. Atassi N, Ratai EM, Greenblatt DJ, Pulley D, Zhao Y, Bombardier J, Wallace S, Eckenrode J, Cudkowicz M, Dibernardo A. A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2010 Dec; 11(6):508-13.

    View in: PubMed


  16. Annamalai L, Bhaskar V, Pauley DR, Knight H, Williams K, Lentz M, Ratai E, Westmoreland SV, Gonzlez RG, O'Neil SP. Impact of short-term combined antiretroviral therapy on brain virus burden in simian immunodeficiency virus-infected and CD8+ lymphocyte-depleted rhesus macaques. Am J Pathol. 2010 Aug; 177(2):777-91.

    View in: PubMed


  17. Ratai EM, Bombardier JP, Joo CG, Annamalai L, Burdo TH, Campbell J, Fell R, Hakimelahi R, He J, Autissier P, Lentz MR, Halpern EF, Masliah E, Williams KC, Westmoreland SV, Gonzlez RG. Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS. PLoS One. 2010; 5(5):e10523.

    View in: PubMed


  18. Liu S, Fleysher R, Fleysher L, Joo CG, Ratai EM, Gonzlez RG, Gonen O. Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. Magn Reson Med. 2010 Apr; 63(4):865-71.

    View in: PubMed


  19. Ramadan S, Ratai EM, Wald LL, Mountford CE. In vivo 1D and 2D correlation MR spectroscopy of the soleus muscle at 7T. J Magn Reson. 2010 May; 204(1):91-8.

    View in: PubMed


  20. Andronesi OC, Ramadan S, Ratai EM, Jennings D, Mountford CE, Sorensen AG. Spectroscopic imaging with improved gradient modulated constant adiabaticity pulses on high-field clinical scanners. J Magn Reson. 2010 Apr; 203(2):283-93.

    View in: PubMed


  21. Wu CL, Jordan KW, Ratai EM, Sheng J, Adkins CB, Defeo EM, Jenkins BG, Ying L, McDougal WS, Cheng LL. Metabolomic imaging for human prostate cancer detection. Sci Transl Med. 2010 Jan 27; 2(16):16ra8.

    View in: PubMed


  22. Liu S, Gonen O, Fleysher R, Fleysher L, Babb JS, Soher BJ, Joo CG, Ratai EM, Gonzlez RG. Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. Magn Reson Med. 2009 Nov; 62(5):1292-9.

    View in: PubMed


  23. Ratai EM, Pilkenton SJ, Greco JB, Lentz MR, Bombardier JP, Turk KW, He J, Joo CG, Lee V, Westmoreland S, Halpern E, Lackner AA, Gonzlez RG. In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain. BMC Neurosci. 2009; 10:63.

    View in: PubMed


  24. Ratai EM, Gonzlez RG. Magnetic Resonance Imaging of the Brain and Spine, edited by Scott W. Atlas. Magnetic Resonance Spectroscopy and the Biochemical Basis of Neurologic Disease. 2009.



  25. Ratai E, Kok T, Wiggins C, Wiggins G, Grant E, Gagoski B, O'Neill G, Adalsteinsson E, Eichler F. Seven-Tesla proton magnetic resonance spectroscopic imaging in adult X-linked adrenoleukodystrophy. Arch Neurol. 2008 Nov; 65(11):1488-94.

    View in: PubMed


  26. Lentz MR, Lee V, Westmoreland SV, Ratai EM, Halpern EF, Gonzlez RG. Factor analysis reveals differences in brain metabolism in macaques with SIV/AIDS and those with SIV-induced encephalitis. NMR Biomed. 2008 Oct; 21(8):878-87.

    View in: PubMed


  27. Liu S, Gonen O, Fleysher L, Fleysher R, Soher BJ, Pilkenton S, Lentz MR, Ratai EM, Gonzlez RG. Regional metabolite T2 in the healthy rhesus macaque brain at 7T. Magn Reson Med. 2008 May; 59(5):1165-9.

    View in: PubMed


  28. Ratai EM, Hancu I, Blezek DJ, Turk KW, Halpern E, Gonzlez RG. Automatic repositioning of MRSI voxels in longitudinal studies: impact on reproducibility of metabolite concentration measurements. J Magn Reson Imaging. 2008 May; 27(5):1188-93.

    View in: PubMed


  29. Gonen O, Liu S, Goelman G, Ratai EM, Pilkenton S, Lentz MR, Gonzlez RG. Proton MR spectroscopic imaging of rhesus macaque brain in vivo at 7T. Magn Reson Med. 2008 Apr; 59(4):692-9.

    View in: PubMed


  30. Lentz MR, Westmoreland SV, Lee V, Ratai EM, Halpern EF, Gonzlez RG. Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS. Magn Reson Med. 2008 Mar; 59(3):475-84.

    View in: PubMed


  31. Singhal AB, Ratai E, Benner T, Vangel M, Lee V, Koroshetz WJ, Schaefer PW, Sorensen AG, Gonzalez RG. Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke. Stroke. 2007 Oct; 38(10):2851-4.

    View in: PubMed


  32. Gonzlez RG, Greco JB, He J, Lentz MR, O'Neil S, Pilkenton SJ, Ratai EM, Westmoreland S. New insights into the neuroimmunity of SIV infection by magnetic resonance spectroscopy. J Neuroimmune Pharmacol. 2006 Jun; 1(2):152-9.

    View in: PubMed


  33. Williams K, Westmoreland S, Greco J, Ratai E, Lentz M, Kim WK, Fuller RA, Kim JP, Autissier P, Sehgal PK, Schinazi RF, Bischofberger N, Piatak M, Lifson JD, Masliah E, Gonzlez RG. Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS. J Clin Invest. 2005 Sep; 115(9):2534-45.

    View in: PubMed


  34. Ratai EM, Pilkenton S, Lentz MR, Greco JB, Fuller RA, Kim JP, He J, Cheng LL, Gonzlez RG. Comparisons of brain metabolites observed by HRMAS 1H NMR of intact tissue and solution 1H NMR of tissue extracts in SIV-infected macaques. NMR Biomed. 2005 Jun; 18(4):242-51.

    View in: PubMed


  35. Kim JP, Lentz MR, Westmoreland SV, Greco JB, Ratai EM, Halpern E, Lackner AA, Masliah E, Gonzlez RG. Relationships between astrogliosis and 1H MR spectroscopic measures of brain choline/creatine and myo-inositol/creatine in a primate model. AJNR Am J Neuroradiol. 2005 Apr; 26(4):752-9.

    View in: PubMed


  36. Lentz MR, Kim JP, Westmoreland SV, Greco JB, Fuller RA, Ratai EM, He J, Sehgal PK, Halpern EF, Lackner AA, Masliah E, Gonzlez RG. Quantitative neuropathologic correlates of changes in ratio of N-acetylaspartate to creatine in macaque brain. Radiology. 2005 May; 235(2):461-8.

    View in: PubMed


  37. Greco JB, Westmoreland SV, Ratai EM, Lentz MR, Sakaie K, He J, Sehgal PK, Masliah E, Lackner AA, Gonzlez RG. In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDS. Magn Reson Med. 2004 Jun; 51(6):1108-14.

    View in: PubMed


  38. Fuller RA, Westmoreland SV, Ratai E, Greco JB, Kim JP, Lentz MR, He J, Sehgal PK, Masliah E, Halpern E, Lackner AA, Gonzlez RG. A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS. BMC Neurosci. 2004 Mar 5; 5:10.

    View in: PubMed


  39. Cramer C, Gao Y, Brunklaus S, Ratai E. Ion Dynamics in Mixed Alkali Borate Glasses. Zeitschrift fr Physikalische Chemie. 2004; 218(12):1413-1428 .



  40. Cramer C, Brunklaus S, Ratai E, Gao Y. New mixed alkali effect in the ac conductivity of ion-conducting glasses. Phys Rev Lett. 2003 Dec 31; 91(26 Pt 1):266601.

    View in: PubMed


  41. Ratai E, Augustine MP, Kauzlarich SM. Synthesis and Characterization of the Mg2SixGe1-x Solid Solution. J. Phys. Chem. B. 2003; 107(46):12573-12577.



  42. Ratai E.-M.; Janssen M.; Epping J.D.; Chan J.C.C.; Eckert H. . Local and medium range order in alkali borate glasses: an overview of recent solid state NMR results. Physics and Chemistry of Glasses. 2003; 44(2):45-53.



  43. Baldwin RK, Pettigrew KA, Ratai E, Augustine MP, Kauzlarich SM. Solution reduction synthesis of surface stabilized silicon nanoparticles. Chem Commun (Camb). 2002 Sep 7; (17):1822-3.

    View in: PubMed


  44. Ratai E, Chan JCC, Eckert H. Local Coordination and spatial distribution of cations in mixed-alkali borate glasses. Physical Chemistry Chemical Physics. 2002; 4(14):3198-3208.



  45. Ratai E, Bruins P, Hernandez CJ, Kauzlarich SM, and Augustine MP. Magnetic Resonance Study of a Series of Phosphorus-Containing Zintl Compounds: Ca14AlP11, Ca14MnP11, and Eu14MnP11. Chemistry of Materials. 2002; 14(6):2467-2475.



  46. Schoo U, Cramer C, Ratai E, Mehrer H. Diffusion in single and mixed-alkali borate glasses. Diffusion in single and mixed-alkali borate glasses. Diffusion in single and mixed-alkali borate glasses. 2001; 194-199:925-933.



  47. Ratai E, Janssen M, Eckert H. Solid State Ionics. Spatial distributions and chemical environments of cations in single- and mixed alkali borate glasses: evidence from solid state NMR. 1998; 105(1-4):25-37.



  48. Kanert O, Kuchler R, Peters J, Volmari A, Jain H, Eckert H, Ratai E. Journal of Non-Crystalline Solids. Structural basis of low-frequency excitations in silicophosphate glasses. 1997; 222:321-328.