Matthew Rosen, PhD
Instructor in Radiology, Harvard Medical School
Assistant in Biomedical Engineering, Massachusetts General Hospital
Senior Research Scientist, Harvard University, Department of Physics
BS Physics, Rensselaer Polytechnic Institute, Troy NY,
PhD Physics, The University of Michigan, Ann Arbor MI,
Martinos Center for Biomedical Imaging
149 13th Street, Suite 2301
Charlestown, MA 02129 USA
General Contact Information
My research interests focus on spin-polarized materials and their use as magnetic tracers for in vivo MRI, in solid, liquid, and gas phase. One aspect of this uses spin-exchange optical pumping techniques to produce long-lived polarizations of order unity in the spin 1/2 noble gas isotopes 3He and 129Xe.
We have developed and constructed a high-volume 3He polarizer and an open-access custom-made 6.5 mT low-field MRI (LFI) scanner, the combination of these technologies allowed our collaboration to image for the first time the orientation-dependent tomographic distribution of oxygen partial pressure in humans in vivo. I have an ongoing interest in orientation-variable imaging for studies of human cardiopulmonary physiology and we plan to correlate our MRI measurements of pulmonary perfusion and ventilation with those obtained from other imaging modalities such as PET imaging.