Jonghwan Lee, PhD
Instructor, Harvard Medical School
Assistant in Biomedical Engineering, Massachusetts General Hospital
PhD Neural Engineering, Seoul National University, South Korea, 2009
Bldg 149, Room 2301
Charlestown, MA 02129 USA
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Spatiotemporal imaging of neural activity of the brain plays a critical role in the study of brain function and the origins of neurological disorders. In order to advance our knowledge of the spatiotemporal organization of neural activity, instrumentation is needed that enables noninvasive, label-free, and three-dimensional dynamic imaging of the activity with m and ms resolution. At the beginning of PhD work, I independently established my long-term research goal to develop novel optical neuroimaging technologies that satisfy these criteria. This long-term goal has guided my previous work and will guide my future work as well. As the first step toward the goal, my PhD work validated the feasibility of measuring fast optical signals (ms time scale) in ex vivo brain tissue at a single point (i.e., zero dimensions). As a synergistic line of research, I also developed multi-physics neuron model for cellular volume dynamics, which elucidates the origin of fast optical signals. I chose to pursue the second step of the research as my postdoctoral work at the Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School. The objective of the second step is to develop optical coherence tomography (OCT)-based technologies for 3D in vivo imaging of neuronal activity in the rodent cerebral cortex with m and ms resolution. In pursuing this objective, I also developed a novel dynamic light scattering (DLS) theory for combination with OCT, which enables m-resolution quantitative in vivo imaging of cellular/vascular dynamics. Novel optical imaging technologies will be further developed and applied not only to the basic study of brain function but also to the study of health-related problems such as stroke.