Katherine Perdue

Athinoula A. Martinos Center for Biomedical Imaging
149 Thirteenth Street, Suite 2301
Charlestown, MA, 02129
Email: kperdue at nmr dot mgh dot harvard dot edu

Education:

Thayer School of Engineering at Dartmouth, Hanover, NH.
        PhD in Engineering Sciences, December 2012.
        Entered June 2008.

College of Engineering, Boston University, Boston, MA.
        Graduate Coursework in Biomedical Engineering.
        September 2007-May 2008.

Harvey Mudd College, Claremont, CA.
        B.S. in Physics, May 2005.
        Concentrations: Biophysics and Cognitive Science.

Research Experience:

Research Assistant
Multimodal Neuroimaging Lab, Thayer School of Engineering at Dartmouth June 2008-present
        Modeling the benefit of combining diffuse optical tomography and electromagnetic imaging in spatial and temporal domains. Developing statistical methods to quantify neurovascular coupling for biomarker development. Advised by Dr. Solomon Diamond, joint work with Dr. David Boas and the Optics Division at the Martinos Center for Biomedical Imaging.

Independent Study
Brain and Vision Lab, BME Dept., Boston University Sept. 2007-May 2008
          Researched the effect of learning a visual motion perception task on brain activation as shown in functional MRI, to compare with computational models of neural connections. Implemented an event-related design using an in-house MATLAB toolbox based on Psychtoolbox. Advised by Dr. Lucia Vaina.

Research Assistant
Martinos Center for Biomedical Imaging June 2005-July 2007
        Explored neural basis of sensorimotor recovery from stroke. Analyzed structural, functional, and diffusion MRI data in stroke patients and normal controls. Acquired and analyzed MEG of motor function of normal controls and stroke patients. Used Freesurfer, AFNI, SUMA, Freediffusion, MNE tools, FSL tools, and MATLAB. Under supervision of Dr. Judith Schaechter.

Senior Thesis
Magnetism Group, Dept. of Physics, HMC August 2004-May 2005
        Studied the nature of antiferromagnet-ferromagnet interaction in spin valves with pico-scale IrMn layers. Used high magnetic field and low temperature environment created by the Physical Properties Measurement System. Advisors were Dr. James Eckert and Dr. Patricia Sparks.

Awards:

Neukom Prize for Outstanding Graduate Research, 2nd place, 2012.
Neukom Institute Travel Award, March 2011, October 2012.
National Science Foundation Graduate Research Fellowship, 2007-2010.
Focke Award for outstanding senior thesis in experimental physics, 2005.
Dean's list, Fall 2002, Spring 2003, Fall 2003, Spring 2004, Fall 2004, Spring 2005.

Publications:

Perdue, K.L., Fang, Q., & Diamond, S. G. Quantitative assessment of diffuse optical tomography sensitivity to the cerebral cortex using a whole-head probe. Physics in Medicine and Biology, 57, 2857-2872, (2012). URL http://dx.doi.org/10.1088/0031-9155/57/10/2857

Gagnon, L., Yücel, M. A., Dehaes, M., Cooper R. J., Perdue, K. L., Selb, J., Huppert, T. J., Hoge, R. D., & Boas, D. A. Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements. Neuroimage, 59, 3933-3940, (2012). URL http://dx.doi.org/10.1016/j.neuroimage.2011.10.054

Gagnon, L., Cooper, R. J., Yücel, M. A., Perdue, K. L., Greve, D. N., & Boas, D. A. Short separation channel location impacts the performance of short channel regression in NIRS. Neuroimage, 59, 2518-2528, (2012). URL http://dx.doi.org/10.1016/j.neuroimage.2011.08.095

Gagnon, L., Perdue, K. L., Greve, D. N., Goldenholz, D., Kaskhedikar, G., & Boas, D. A. Improved recovery of the hemodynamic response in Diffuse Optical Imaging using short optode separations and state-space modeling. Neuroimage, 56, 1362-1371, (2011). URL http://dx.doi.org/10.1016/j.neuroimage.2011.03.001

Diamond, S. G., Perdue, K. L., & Boas, D. A. A cerebrovascular response model for functional neuroimaging including dynamic cerebral autoregulation. Mathematical Biosciences, 220, 102-117, (2009). URL http://dx.doi.org/10.1016/j.mbs.2009.05.002

Schaechter, J. D., Fricker, Z. P., Perdue, K. L., Helmer, K., Greve, D. N., & Makris, N. Microstructural status of ipsilesional and contralesional corticospinal tract correlates with motor skill in chronic stroke patients. Human Brain Mapping, 30, 3461-3474, (2009). URL http://dx.doi.org/10.1002/hbm.20770

Schaechter, J. D., Perdue, K. L. & Wang, R. Structural damage to the corticospinal tract correlates with bilateral sensorimotor cortex reorganization in stroke patients. Neuroimage, 39, 1370-1382 (2008). URL http://dx.doi.org/10.1016/j.neuroimage.2007.09.071

Schaechter, J. D. & Perdue, K. L. Enhanced Cortical Activation in the Contralesional Hemisphere of Chronic Stroke Patients in Response to Motor Skill Challenge. Cerebral Cortex, 18, 638-647 (2008). URL http://dx.doi.org/10.1093/cercor/bhm096.

Schaechter, J. D., Stokes, C., Connell, B. D., Perdue, K. & Bonmassar, G. Finger motion sensors for fmri motor studies. Neuroimage 31, 1549-1559 (2006). URL http://dx.doi.org/10.1016/j.neuroimage.2006.02.029.

Moyerman, S., Eckert, J. C., Borchers, J. A., Perdue, K. L., Doucet, M., Sparks, P. D. & Carey, M. J. Magnetic Structure Variations During GMR Training in Spin Valves with Pico-Scale Antiferromagnetic Layers. J. Appl. Phys. 99, 08R505 (2006). URL http://dx.doi.org/10.1063/1.2165607.

Perdue, K. L., Carey, M. J., Sparks, P. D. & Eckert, J.C. Exchange Bias and Giant Magnetoresistance in Spin Valves with Angstrom-Scale Antiferromagnetic Layers at 5K. IEEE Transactions on Magnetics, 41, 2706 (2005). URL http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=1519095.

Shakespear, K. F., Perdue, K. L., Moyerman, S. M., Checkelsky, J. G., Harberger, S. S., Tamboli, A. C., Carey, M. J., Sparks, P. D. & Eckert J. C. Determining the Spin Dependent Mean Free Path in Co90Fe10 Using Giant Magnetoresistance. J. Appl. Phys. 97, 10C513 (2005). URL http://dx.doi.org/10.1063/1.1853236.


Conference Presentations:

Perdue, K.L., & Diamond, S.G. Comparison of NIRS, EEG, MEG and fMRI sensitivity to the spatial scale of brain activity. Functional Near Infrared Spectroscopy, London, U. K. October 2012.

Perdue, K.L., & Diamond, S.G. Anatomical Vasculature Modeling for Functional Near-Infrared Spectroscopy. Annual Meeting of the Organization for Human Brain Mapping, Quebec City, Canada. June 2011.

Perdue K. L., & Diamond, S. G. Relating the spatial distribution of mu rhythm phase with hemodynamics for studies of neurovascular coupling. Annual Meeting of the Society for Neuroscience, San Diego, CA. November 2010.

Perdue, K. L., & Diamond, S. G. Automated motion correction for event-related fNIRS studies. Functional Near Infrared Spectroscopy Conference, Cambridge, MA. October 2010.

Perdue, K. L., Boas, D. A., & Diamond, S. G. Temporal reconstruction of multimodal brain activity using MEG and DOT. Workshop on Inverse Problems in Brain Imaging and Multimodal Fusion, Centre de Recherches Mathematiques, Montreal, Canada. August 2009.

Perdue, K., Boas, D., & Diamond, S. Combining Magnetoencephalography and Diffuse Optical Tomography for Human Neuroimaging. Annual Meeting of the Organization for Human Brain Mapping , San Francisco, CA. June 2009.

Perdue, K., Boas, D., & Diamond, S. Combining diffuse optical and electromagnetic forward models for improved neurovascular tomography. Gordon Reserach Conference on Brain Energy Metabolism and Blood Flow, Andover, NH. August 2008.

Schaechter, J. D., & Perdue K. Cortical activation in stroke patients during synergistic and nonsynergistic motor tasks. Annual Meeting of the Society for Neuroscience, Atlanta, GA. October 2006.

Perdue, K. L., Carey, M. J., Sparks, P. D., & Eckert, J. C. Exchange Bias and Giant Magnetoresistance in Spin Valves with Pico-Scale Antiferromagnetic Layers. IEEE International Magnetics Conference, Nagoya, Japan. April 2005.

Shakespear, K. F., Moyerman, S. M., Perdue, K. L., Harberger, S. S., Checkelsky, J. G., Carey, M. J., Tamboli, A. C., Sparks, P. D., & Eckert, J. C. Temperature dependence of the spin dependent mean free path in CoFe. 49th Annual Conference on Magnetism and Magnetic Materials, Jacksonville, FL. November 2004.


Teaching Experience:

Ethics Facilitator
Thayer School of Engineering, Dartmouth College Fall 2010, 2011
         Led discussions on ethics and professionalism for first-year graduate students.

Teaching Assistant
Thayer School of Engineering, Dartmouth College Spring 2009
         Graded homework and held office hours for ENGS110: Signal Processing. Graduate level course. Citation for Outstanding Performance.

Instructor
Dept. of Humanities, Harvey Mudd College Spring 2005
        Created and taught a course in comparative Identity Studies for upper-level Harvey Mudd students. Co-taught with another student, under the supervision of Dr. Richard Olson.

Lab Assistant
Dept. of Physics, Harvey Mudd College Fall 2003 and Spring 2004
        Taught basic physics lab skills to freshmen and sophomores. Tasks included troubleshooting equipment, teaching error analysis, and grading homework.

Professional Service and Memberships:

Reviewer, Optics Letters
Reviewer, Optics Express
Reviewer, Journal of Biomedical Optics
Reviewer, Applied Optics
Physics Content Reviewer, Science Scope
Member, IEEE
Member, Organization for Human Brain Mapping
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