Selected Publications

  1. Wu O, Cloonan L, Mocking SJT, Bouts MJRJ, Copen WA, Cougo-Pinto PT, Fitzpatrick K, Kanakis A, Schaefer PW, Rosand J, Furie KL, Rost NS. Role of acute lesion topography in initial stroke severity and long-term functional outcomes. Stroke. 2015;46:00-00. DOI:10.1161/STROKEAHA.115.009643. URL: http://www.ncbi.nlm.nih.gov/pubmed/26199314

  2. Copen WA, Morais LT, Wu O, Schwamm LH, Schaefer PW,González RG, Yoo AJ. In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core? PLoS One. 2015 Jul 20;10(7):e0133566. doi: 10.1371/journal.pone.0133566. http://www.ncbi.nlm.nih.gov/pubmed/26193486

  3. Hirsch KG, Mlynash M, Eyngorn I, Pirsaheli R, Okada A, Komshian S, Chen C, Mayer SA, Meschia JF, Bernstein RA, Wu O, Greer DM, Wijman CA, Albers GW. Multi-center study of diffusion-weighted imaging in coma after cardiac arrest. Neurocrit Care. Jul 9. [Epub ahead of print URL: http://www.ncbi.nlm.nih.gov/pubmed/26156112.

  4. Wintermark M, Luby M, Bornstein NM, Demchuk A, Fiehler J, Kudo K, Lees KR, Liebeskind DS, Michel P, Nogueira RG, Parsons MW, Sasaki M, Wardlaw JM, Wu O, Zhang W, Zhu G, Warach SJ. International survey of acute Stroke imaging used to make revascularization treatment decisions. Int J Stroke. 2015;10(5):759-62. URL: http://www.ncbi.nlm.nih.gov/pubmed/25833105.

  5. Schaefer PW, Pulli B, Copen WA, Hirsch JA, Leslie-Mazwi T, Schwamm LH, Wu O, Gonzalez RG, Yoo AJ. Combining MRI with NIHSS thresholds to predict outcome in acute ischemic stroke: value for patient selection. AJNR Am J Neuroradiol. 2015;36(2):259-64. URL: http://www.ncbi.nlm.nih.gov/pubmed/25258369.

  6. Jafari-Khouzani K, Emblem KE, Kalpathy-Cramer J, Bjornerud A, Vangel MG, Gerstner ER, Schmainda KM, Paynabar K, Wu O, Wen PY, Batchelor T, Rosen B, Stufflebeam SM. Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients. Translational oncology. 2015;8(3):137-46. URL: http://www.ncbi.nlm.nih.gov/pubmed/26055170.

  7. Copen WA, Deipolyi AR, Schaefer PW, Schwamm LH, Gonzalez RG, Wu O. Exposing hidden truncation-related errors in acute stroke perfusion imaging. AJNR Am J Neuroradiol. 2015;36(4):638-45. URL: http://www.ncbi.nlm.nih.gov/pubmed/25500309.

  8. Chu CJ, Tanaka N, Diaz J, Edlow BL, Wu O, Hamalainen M, Stufflebeam S, Cash SS, Kramer MA. EEG functional connectivity is partially predicted by underlying white matter connectivity. Neuroimage. 2015;108:23-33. PMCID: PMC4323839. URL: http://www.ncbi.nlm.nih.gov/pubmed/25534110.

  9. Schroder J, Cheng B, Ebinger M, Kohrmann M, Wu O, Kang DW, Liebeskind DS, Tourdias T, Singer OC, Christensen S, Campbell B, Luby M, Warach S, Fiehler J, Fiebach JB, Gerloff C, Thomalla G, Stir, Investigators VI. Validity of acute stroke lesion volume estimation by diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomographic Score depends on lesion location in 496 patients with middle cerebral artery stroke. Stroke. 2014;45(12):3583-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/25316278.

  10. Kimberly WT, Battey TW, Pham L, Wu O, Yoo AJ, Furie KL, Singhal AB, Elm JJ, Stern BJ, Sheth KN. Glyburide is associated with attenuated vasogenic edema in stroke patients. Neurocrit Care. 2014;20(2):193-201. URL: http://www.ncbi.nlm.nih.gov/pubmed/24072459.

  11. Kamps MJ, Horn J, Oddo M, Fugate JE, Storm C, Cronberg T, Wu O, Binnekade JM, Hoedemaekers CW. Response to De Jonghe et al.: Prognostication of neurological outcome after cardiac arrest: standardization of neurological examination conditions is needed. Intensive Care Med. 2014;40(2):295. URL: http://www.ncbi.nlm.nih.gov/pubmed/24306085.

  12. Greer DM, Rosenthal ES, Wu O. Neuroprognostication of hypoxic-ischaemic coma in the therapeutic hypothermia era. Nat Rev Neurol. 2014;10(4):190-203. URL: http://www.ncbi.nlm.nih.gov/pubmed/24614515.

  13. Dalca AV, Sridharan R, Cloonan L, Fitzpatrick KM, Kanakis A, Furie KL, Rosand J, Wu O, Sabuncu M, Rost NS, Golland P. Segmentation of cerebrovascular pathologies in stroke patients with spatial and shape priors. Med Image Comput Comput Assist Interv. 2014;17(Pt 2):773-80. PMCID: PMC4260817. URL: http://www.ncbi.nlm.nih.gov/pubmed/25485450.

  14. Battey TW, Karki M, Singhal AB, Wu O, Sadaghiani S, Campbell BC, Davis SM, Donnan GA, Sheth KN, Kimberly WT. Brain edema predicts outcome after nonlacunar ischemic stroke. Stroke. 2014;45(12):3643-8. PMCID: PMC4295905. URL: http://www.ncbi.nlm.nih.gov/pubmed/25336512.

  15. Auriel E, Edlow BL, Reijmer YD, Fotiadis P, Ramirez-Martinez S, Ni J, Reed AK, Vashkevich A, Schwab K, Rosand J, Viswanathan A, Wu O, Gurol ME, Greenberg SM. Microinfarct disruption of white matter structure: a longitudinal diffusion tensor analysis. Neurology. 2014;83(2):182-8. PMCID: PMC4117171. URL: http://www.ncbi.nlm.nih.gov/pubmed/24920857.

  16. Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, Grotta JC, Houser G, Jovin TG, Lees KR, Lev MH, Liebeskind DS, Luby M, Muir KW, Parsons MW, von Kummer R, Wardlaw JM, Wu O, Yoo AJ, Alexandrov AV, Alger JR, Aviv RI, Bammer R, Baron JC, Calamante F, Campbell BC, Carpenter TC, Christensen S, Copen WA, Derdeyn CP, Haley EC, Jr., Khatri P, Kudo K, Lansberg MG, Latour LL, Lee TY, Leigh R, Lin W, Lyden P, Mair G, Menon BK, Michel P, Mikulik R, Nogueira RG, Ostergaard L, Pedraza S, Riedel CH, Rowley HA, Sanelli PC, Sasaki M, Saver JL, Schaefer PW, Schellinger PD, Tsivgoulis G, Wechsler LR, White PM, Zaharchuk G, Zaidat OO, Davis SM, Donnan GA, Furlan AJ, Hacke W, Kang DW, Kidwell C, Thijs VN, Thomalla G, Warach SJ, Stroke Imaging R, Virtual International Stroke Trials Archive -Imaging I. Acute Stroke Imaging Research Roadmap II. Stroke. 2013;44(9):2628-39. PMCID: PMC4040226. URL: http://www.ncbi.nlm.nih.gov/pubmed/23860298.

  17. Sridharan R, Dalca AV, Fitzpatrick KM, Cloonan L, Kanakis A, Wu O, Furie KL, Rosand J, Rost NS, Golland P. Quantification and Analysis of Large Multimodal Clinical Image Studies: Application to Stroke. Multimodal Brain Image Anal (2013). 2013;8159:18-30. PMCID: PMC4306599. URL: http://www.ncbi.nlm.nih.gov/pubmed/25632408.

  18. Saver JL, Jovin TG, Smith WS, Albers GW, Baron JC, Boltze J, Broderick JP, Davis LA, Demchuk AM, DeSena S, Fiehler J, Gorelick PB, Hacke W, Holt B, Jahan R, Jing H, Khatri P, Kidwell CS, Lees KR, Lev MH, Liebeskind DS, Luby M, Lyden P, Megerian JT, Mocco J, Muir KW, Rowley HA, Ruedy RM, Savitz SI, Sipelis VJ, Shimp SK, 3rd, Wechsler LR, Wintermark M, Wu O, Yavagal DR, Yoo AJ, Consortium SV. Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices. Stroke. 2013;44(12):3596-601. PMCID: PMC4142766. URL: http://www.ncbi.nlm.nih.gov/pubmed/24193797.

  19. Rowley J, Fonov V, Wu O, Eskildsen SF, Schoemaker D, Wu L, Mohades S, Shin M, Sziklas V, Cheewakriengkrai L, Shmuel A, Dagher A, Gauthier S, Rosa-Neto P, Alzheimer's Disease Neuroimaging I. White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and Alzheimer's disease. PLoS One. 2013;8(9):e74776. PMCID: PMC3785512. URL: http://www.ncbi.nlm.nih.gov/pubmed/24086371.

  20. Meschia JF, Arnett DK, Ay H, Brown RD, Jr., Benavente OR, Cole JW, de Bakker PI, Dichgans M, Doheny KF, Fornage M, Grewal RP, Gwinn K, Jern C, Conde JJ, Johnson JA, Jood K, Laurie CC, Lee JM, Lindgren A, Markus HS, McArdle PF, McClure LA, Mitchell BD, Schmidt R, Rexrode KM, Rich SS, Rosand J, Rothwell PM, Rundek T, Sacco RL, Sharma P, Shuldiner AR, Slowik A, Wassertheil-Smoller S, Sudlow C, Thijs VN, Woo D, Worrall BB, Wu O, Kittner SJ, Study NS. Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes. Stroke. 2013;44(10):2694-702. PMCID: PMC4056331. URL: http://www.ncbi.nlm.nih.gov/pubmed/24021684.

  21. Kamps MJ, Horn J, Oddo M, Fugate JE, Storm C, Cronberg T, Wijman CA, Wu O, Binnekade JM, Hoedemaekers CW. Prognostication of neurologic outcome in cardiac arrest patients after mild therapeutic hypothermia: a meta-analysis of the current literature. Intensive Care Med. 2013;39(10):1671-82. URL: http://www.ncbi.nlm.nih.gov/pubmed/23801384.

  22. Greer DM, Yang J, Scripko PD, Sims JR, Cash S, Wu O, Hafler JP, Schoenfeld DA, Furie KL. Clinical examination for prognostication in comatose cardiac arrest patients. Resuscitation. 2013;84(11):1546-51. PMCID: PMC4041075. URL: http://www.ncbi.nlm.nih.gov/pubmed/23954666.

  23. Greer DM, Scripko PD, Wu O, Edlow BL, Bartscher J, Sims JR, Camargo EE, Singhal AB, Furie KL. Hippocampal magnetic resonance imaging abnormalities in cardiac arrest are associated with poor outcome. J Stroke Cerebrovasc Dis. 2013;22(7):899-905. URL: http://www.ncbi.nlm.nih.gov/pubmed/22995378.

  24. Edlow BL, Haynes RL, Takahashi E, Klein JP, Cummings P, Benner T, Greer DM, Greenberg SM, Wu O, Kinney HC, Folkerth RD. Disconnection of the ascending arousal system in traumatic coma. J Neuropathol Exp Neurol. 2013;72(6):505-23. PMCID: PMC3761353. URL: http://www.ncbi.nlm.nih.gov/pubmed/23656993.

  25. Edlow BL, Giacino JT, Wu O. Functional MRI and outcome in traumatic coma. Curr Neurol Neurosci Rep. 2013;13(9):375. PMCID: PMC3811121. URL: http://www.ncbi.nlm.nih.gov/pubmed/23881623.

  26. Edlow BL, Giacino JT, Hirschberg RE, Gerrard J, Wu O, Hochberg LR. Unexpected recovery of function after severe traumatic brain injury: the limits of early neuroimaging-based outcome prediction. Neurocrit Care. 2013;19(3):364-75. PMCID: PMC3902071. URL: http://www.ncbi.nlm.nih.gov/pubmed/23860665.

  27. Cheng B, Brinkmann M, Forkert ND, Treszl A, Ebinger M, Kohrmann M, Wu O, Kang DW, Liebeskind DS, Tourdias T, Singer OC, Christensen S, Luby M, Warach S, Fiehler J, Fiebach JB, Gerloff C, Thomalla G, Stir, Investigators VI. Quantitative measurements of relative fluid-attenuated inversion recovery (FLAIR) signal intensities in acute stroke for the prediction of time from symptom onset. J Cereb Blood Flow Metab. 2013;33(1):76-84. PMCID: PMC3965287. URL: http://www.ncbi.nlm.nih.gov/pubmed/23047272.

  28. Bouts MJ, Tiebosch IA, van der Toorn A, Viergever MA, Wu O, Dijkhuizen RM. Early identification of potentially salvageable tissue with MRI-based predictive algorithms after experimental ischemic stroke. J Cereb Blood Flow Metab. 2013;33(7):1075-82. PMCID: PMC3705436. URL: http://www.ncbi.nlm.nih.gov/pubmed/23571283.

  29. Wu O, Lu J, Mandeville JB, Murata Y, Egi Y, Dai G, Marota JJ, Diwan I, Dijkhuizen RM, Kwong KK, Lo EH, Singhal AB. Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke. J Cereb Blood Flow Metab. 2012;32(9):1800-9. PMCID: PMC3434635. URL: http://www.ncbi.nlm.nih.gov/pubmed/22739619.

  30. Wu O, Benner T, Roccatagliata L, Zhu M, Schaefer PW, Sorensen AG, Singhal AB. Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive models. Med Gas Res. 2012;2(1):5. PMCID: PMC3388462. URL: http://www.ncbi.nlm.nih.gov/pubmed/22404875.

  31. Song SS, Latour LL, Ritter CH, Wu O, Tighiouart M, Hernandez DA, Ku KD, Luby M, Warach S. A pragmatic approach using magnetic resonance imaging to treat ischemic strokes of unknown onset time in a thrombolytic trial. Stroke. 2012;43(9):2331-5. PMCID: PMC3464959. URL: http://www.ncbi.nlm.nih.gov/pubmed/22693129.

  32. Greer DM, Yang J, Scripko PD, Sims JR, Cash S, Kilbride R, Wu O, Hafler JP, Schoenfeld DA, Furie KL. Clinical examination for outcome prediction in nontraumatic coma. Crit Care Med. 2012;40(4):1150-6. URL: http://www.ncbi.nlm.nih.gov/pubmed/22020245.

  33. Edlow BL, Wu O. Advanced neuroimaging in traumatic brain injury. Semin Neurol. 2012;32(4):374-400. PMCID: PMC3779469. URL: http://www.ncbi.nlm.nih.gov/pubmed/23361483.

  34. Edlow BL, Takahashi E, Wu O, Benner T, Dai G, Bu L, Grant PE, Greer DM, Greenberg SM, Kinney HC, Folkerth RD. Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders. J Neuropathol Exp Neurol. 2012;71(6):531-46. PMCID: PMC3387430. URL: http://www.ncbi.nlm.nih.gov/pubmed/22592840.

  35. Deipolyi AR, Wu O, Macklin EA, Schaefer PW, Schwamm LH, Gilberto Gonzalez R, Copen WA. Reliability of cerebral blood volume maps as a substitute for diffusion-weighted imaging in acute ischemic stroke. J Magn Reson Imaging. 2012;36(5):1083-7. PMCID: PMC4110961. URL: http://www.ncbi.nlm.nih.gov/pubmed/22761110.

  36. Cheng B, Ebinger M, Kufner A, Kohrmann M, Wu O, Kang DW, Liebeskind D, Tourdias T, Singer OC, Christensen S, Warach S, Luby M, Fiebach JB, Fiehler J, Gerloff C, Thomalla G, Stroke Imaging Repository I. Hyperintense vessels on acute stroke fluid-attenuated inversion recovery imaging: associations with clinical and other MRI findings. Stroke. 2012;43(11):2957-61. PMCID: PMC3495102. URL: http://www.ncbi.nlm.nih.gov/pubmed/22933582.

  37. Arkink EB, Bleeker EJ, Schmitz N, Schoonman GG, Wu O, Ferrari MD, van Buchem MA, van Osch MJ, Kruit MC. Cerebral perfusion changes in migraineurs: a voxelwise comparison of interictal dynamic susceptibility contrast MRI measurements. Cephalalgia. 2012;32(4):279-88. PMCID: PMC3743424. URL: http://www.ncbi.nlm.nih.gov/pubmed/22290556.

  38. Wu O, Schwamm LH, Sorensen AG. Imaging stroke patients with unclear onset times. Neuroimaging Clin N Am. 2011;21(2):327-44, xi. PMCID: PMC3109317. URL: http://www.ncbi.nlm.nih.gov/pubmed/21640303.

  39. Wu O, Batista LM, Lima FO, Vangel MG, Furie KL, Greer DM. Predicting clinical outcome in comatose cardiac arrest patients using early noncontrast computed tomography. Stroke. 2011;42(4):985-92. PMCID: PMC3107844. URL: http://www.ncbi.nlm.nih.gov/pubmed/21330629.

  40. Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, Kim JS, Breuer L, Singer OC, Warach S, Christensen S, Treszl A, Forkert ND, Galinovic I, Rosenkranz M, Engelhorn T, Kohrmann M, Endres M, Kang DW, Dousset V, Sorensen AG, Liebeskind DS, Fiebach JB, Fiehler J, Gerloff C, Stir, Investigators VI. DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4.5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol. 2011;10(11):978-86. URL: http://www.ncbi.nlm.nih.gov/pubmed/21978972.

  41. Kwong KK, Wu O, Chan ST, Nelissen K, Kholodov M, Chesler DA. Early time points perfusion imaging: relative time of arrival, maximum derivatives and fractional derivatives. Neuroimage. 2011;57(3):979-90. PMCID: PMC3129483. URL: http://www.ncbi.nlm.nih.gov/pubmed/21600995.

  42. Kwong KK, Reese TG, Nelissen K, Wu O, Chan ST, Benner T, Mandeville JB, Foley M, Vanduffel W, Chesler DA. Early time points perfusion imaging. Neuroimage. 2011;54(2):1070-82. PMCID: PMC2997123. URL: http://www.ncbi.nlm.nih.gov/pubmed/20851196.

  43. Kimberly WT, Wu O, Arsava EM, Garg P, Ji R, Vangel M, Singhal AB, Ay H, Sorensen AG. Lower hemoglobin correlates with larger stroke volumes in acute ischemic stroke. Cerebrovasc Dis Extra. 2011;1(1):44-53. PMCID: PMC3343751. URL: http://www.ncbi.nlm.nih.gov/pubmed/22566982.

  44. Gokcay F, Arsava EM, Baykaner T, Vangel M, Garg P, Wu O, Singhal AB, Furie KL, Sorensen AG, Ay H. Age-dependent susceptibility to infarct growth in women. Stroke. 2011;42(4):947-51. PMCID: PMC3066257. URL: http://www.ncbi.nlm.nih.gov/pubmed/21311058.

  45. Copen WA, Schaefer PW, Wu O. MR perfusion imaging in acute ischemic stroke. Neuroimaging Clin N Am. 2011;21(2):259-83, x. PMCID: PMC3135980. URL: http://www.ncbi.nlm.nih.gov/pubmed/21640299.

  46. Wu O, Dijkhuizen RM, Sorensen AG. Multiparametric magnetic resonance imaging of brain disorders. Top Magn Reson Imaging. 2010;21(2):129-38. PMCID: PMC3319343. URL: http://www.ncbi.nlm.nih.gov/pubmed/21613877.

  47. Emmer BJ, van Osch MJ, Wu O, Steup-Beekman GM, Steens SC, Huizinga TW, van Buchem MA, van der Grond J. Perfusion MRI in neuro-psychiatric systemic lupus erthemathosus. J Magn Reson Imaging. 2010;32(2):283-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/20677252.

  48. Wu O, Sorensen AG, Benner T, Singhal AB, Furie KL, Greer DM. Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imaging. Radiology. 2009;252(1):173-81. PMCID: PMC2702469. URL: http://www.ncbi.nlm.nih.gov/pubmed/19420318.

  49. Fujiwara N, Murata Y, Arai K, Egi Y, Lu J, Wu O, Singhal AB, Lo EH. Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. BMC Neurosci. 2009;10:79. PMCID: PMC2714858. URL: http://www.ncbi.nlm.nih.gov/pubmed/19604385.

  50. Copen WA, Rezai Gharai L, Barak ER, Schwamm LH, Wu O, Kamalian S, Gonzalez RG, Schaefer PW. Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion. Radiology. 2009;250(3):878-86. URL: http://www.ncbi.nlm.nih.gov/pubmed/19164120.

  51. Christensen S, Mouridsen K, Wu O, Hjort N, Karstoft H, Thomalla G, Rother J, Fiehler J, Kucinski T, Ostergaard L. Comparison of 10 perfusion MRI parameters in 97 sub-6-hour stroke patients using voxel-based receiver operating characteristics analysis. Stroke. 2009;40(6):2055-61. URL: http://www.ncbi.nlm.nih.gov/pubmed/19359626.

  52. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Kohrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. AJNR Am J Neuroradiol. 2008;29(5):e23-30. PMCID: PMC2716734. URL: http://www.ncbi.nlm.nih.gov/pubmed/18477656.

  53. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Kohrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. Stroke. 2008;39(5):1621-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/18403743.

  54. van der Zijden JP, Bouts MJ, Wu O, Roeling TA, Bleys RL, van der Toorn A, Dijkhuizen RM. Manganese-enhanced MRI of brain plasticity in relation to functional recovery after experimental stroke. J Cereb Blood Flow Metab. 2008;28(4):832-40. URL: http://www.ncbi.nlm.nih.gov/pubmed/17987047.

  55. Hjort N, Wu O, Ashkanian M, Solling C, Mouridsen K, Christensen S, Gyldensted C, Andersen G, Ostergaard L. MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysis. Stroke. 2008;39(3):1025-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/18258832.

  56. Christensen S, Calamante F, Hjort N, Wu O, Blankholm AD, Desmond P, Davis S, Ostergaard L. Inferring origin of vascular supply from tracer arrival timing patterns using bolus tracking MRI. J Magn Reson Imaging. 2008;27(6):1371-81. URL: http://www.ncbi.nlm.nih.gov/pubmed/18504757.

  57. Ay H, Arsava EM, Vangel M, Oner B, Zhu M, Wu O, Singhal A, Koroshetz WJ, Sorensen AG. Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke research. Stroke. 2008;39(4):1171-6. URL: http://www.ncbi.nlm.nih.gov/pubmed/18292377.

  58. Ay H, Arsava EM, Rosand J, Furie KL, Singhal AB, Schaefer PW, Wu O, Gonzalez RG, Koroshetz WJ, Sorensen AG. Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke. Stroke. 2008;39(5):1409-13. URL: http://www.ncbi.nlm.nih.gov/pubmed/18340093.

  59. Wu O, Sumii T, Asahi M, Sasamata M, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM. Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models. J Cereb Blood Flow Metab. 2007;27(1):196-204. URL: http://www.ncbi.nlm.nih.gov/pubmed/16685257.

  60. van der Zijden JP, Wu O, van der Toorn A, Roeling TP, Bleys RL, Dijkhuizen RM. Changes in neuronal connectivity after stroke in rats as studied by serial manganese-enhanced MRI. Neuroimage. 2007;34(4):1650-7. URL: http://www.ncbi.nlm.nih.gov/pubmed/17175175.

  61. Makris N, Papadimitriou GM, van der Kouwe A, Kennedy DN, Hodge SM, Dale AM, Benner T, Wald LL, Wu O, Tuch DS, Caviness VS, Moore TL, Killiany RJ, Moss MB, Rosene DL. Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study. Neurobiol Aging. 2007;28(10):1556-67. URL: http://www.ncbi.nlm.nih.gov/pubmed/16962214.

  62. Wu O, Christensen S, Hjort N, Dijkhuizen RM, Kucinski T, Fiehler J, Thomalla G, Rother J, Ostergaard L. Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI. Brain. 2006;129(Pt 9):2384-93. URL: http://www.ncbi.nlm.nih.gov/pubmed/16891322.

  63. Wu O, Ostergaard L, Sorensen AG. Technical aspects of perfusion-weighted imaging. Neuroimaging Clin N Am. 2005;15(3):623-37, xi. URL: http://www.ncbi.nlm.nih.gov/pubmed/16360593.

  64. Hjort N, Christensen S, Solling C, Ashkanian M, Wu O, Rohl L, Gyldensted C, Andersen G, Ostergaard L. Ischemic injury detected by diffusion imaging 11 minutes after stroke. Ann Neurol. 2005;58(3):462-5. URL: http://www.ncbi.nlm.nih.gov/pubmed/16130095.

  65. Gottrup C, Thomsen K, Locht P, Wu O, Sorensen AG, Koroshetz WJ, Ostergaard L. Applying instance-based techniques to prediction of final outcome in acute stroke. Artif Intell Med. 2005;33(3):223-36. URL: http://www.ncbi.nlm.nih.gov/pubmed/15811787.

  66. Ay H, Koroshetz WJ, Benner T, Vangel MG, Wu O, Schwamm LH, Sorensen AG. Transient ischemic attack with infarction: a unique syndrome? Ann Neurol. 2005;57(5):679-86. URL: http://www.ncbi.nlm.nih.gov/pubmed/15852402.

  67. van Eijsden P, Notenboom RG, Wu O, de Graan PN, van Nieuwenhuizen O, Nicolay K, Braun KP. In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat. Brain Res. 2004;1030(1):11-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/15567333.

  68. Ozsunar Y, Grant PE, Huisman TA, Schaefer PW, Wu O, Sorensen AG, Koroshetz WJ, Gonzalez RG. Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2. AJNR Am J Neuroradiol. 2004;25(5):699-705. URL: http://www.ncbi.nlm.nih.gov/pubmed/15140707.

  69. Huisman TA, Schwamm LH, Schaefer PW, Koroshetz WJ, Shetty-Alva N, Ozsunar Y, Wu O, Sorensen AG. Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. AJNR Am J Neuroradiol. 2004;25(3):370-6. URL: http://www.ncbi.nlm.nih.gov/pubmed/15037457.

  70. Wu O, Ostergaard L, Weisskoff RM, Benner T, Rosen BR, Sorensen AG. Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix. Magn Reson Med. 2003;50(1):164-74. URL: http://www.ncbi.nlm.nih.gov/pubmed/12815691.

  71. Wu O, Ostergaard L, Koroshetz WJ, Schwamm LH, O'Donnell J, Schaefer PW, Rosen BR, Weisskoff RM, Sorensen AG. Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging. Magn Reson Med. 2003;50(4):856-64. URL: http://www.ncbi.nlm.nih.gov/pubmed/14523973.

  72. van Osch MJ, Vonken EJ, Wu O, Viergever MA, van der Grond J, Bakker CJ. Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI. Magn Reson Med. 2003;50(3):614-22. URL: http://www.ncbi.nlm.nih.gov/pubmed/12939770.

  73. Dijkhuizen RM, Singhal AB, Mandeville JB, Wu O, Halpern EF, Finklestein SP, Rosen BR, Lo EH. Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci. 2003;23(2):510-7. URL: http://www.ncbi.nlm.nih.gov/pubmed/12533611.

  74. Yamada K, Wu O, Gonzalez RG, Bakker D, Ostergaard L, Copen WA, Weisskoff RM, Rosen BR, Yagi K, Nishimura T, Sorensen AG. Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy. Stroke. 2002;33(1):87-94. URL: http://www.ncbi.nlm.nih.gov/pubmed/11779894.

  75. Schaefer PW, Romero JM, Grant PE, Wu O, Sorensen AG, Koroshetz W, Gonzalez RG. Perfusion magnetic resonance imaging of acute ischemic stroke. Semin Roentgenol. 2002;37(3):230-6. URL: http://www.ncbi.nlm.nih.gov/pubmed/12226902.

  76. Schaefer PW, Romero JM, Grant PE, Wu O, Sorensen AG, Koroshetz W, Gonzalez RG. Diffusion magnetic resonance imaging of acute ischemic stroke. Semin Roentgenol. 2002;37(3):219-29. URL: http://www.ncbi.nlm.nih.gov/pubmed/12226901.

  77. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke. 2002;33(8):2100-4. URL: http://www.ncbi.nlm.nih.gov/pubmed/12154270.

  78. Yoshiura T, Wu O, Zaheer A, Reese TG, Sorensen AG. Highly diffusion-sensitized MRI of brain: dissociation of gray and white matter. Magn Reson Med. 2001;45(5):734-40. URL: http://www.ncbi.nlm.nih.gov/pubmed/11323798.

  79. Wu O, Koroshetz WJ, Ostergaard L, Buonanno FS, Copen WA, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Sorensen AG. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging. Stroke. 2001;32(4):933-42. URL: http://www.ncbi.nlm.nih.gov/pubmed/11283394.

  80. Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A. 2001;98(8):4687-92. PMCID: PMC31895. URL: http://www.ncbi.nlm.nih.gov/pubmed/11287655.

  81. Grant PE, He J, Halpern EF, Wu O, Schaefer PW, Schwamm LH, Budzik RF, Sorensen AG, Koroshetz WJ, Gonzalez RG. Frequency and clinical context of decreased apparent diffusion coefficient reversal in the human brain. Radiology. 2001;221(1):43-50. URL: http://www.ncbi.nlm.nih.gov/pubmed/11568319.

  82. Dijkhuizen RM, Ren J, Mandeville JB, Wu O, Ozdag FM, Moskowitz MA, Rosen BR, Finklestein SP. Functional magnetic resonance imaging of reorganization in rat brain after stroke. Proc Natl Acad Sci U S A. 2001;98(22):12766-71. PMCID: PMC60128. URL: http://www.ncbi.nlm.nih.gov/pubmed/11606760.

  83. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab. 2001;21(8):964-71. URL: http://www.ncbi.nlm.nih.gov/pubmed/11487732.

  84. Copen WA, Schwamm LH, Gonzalez RG, Wu O, Harmath CB, Schaefer PW, Koroshetz WJ, Sorensen AG. Ischemic stroke: effects of etiology and patient age on the time course of the core apparent diffusion coefficient. Radiology. 2001;221(1):27-34. URL: http://www.ncbi.nlm.nih.gov/pubmed/11568317.

  85. Ostergaard L, Sorensen AG, Chesler DA, Weisskoff RM, Koroshetz WJ, Wu O, Gyldensted C, Rosen BR. Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. Stroke. 2000;31(5):1097-103. URL: http://www.ncbi.nlm.nih.gov/pubmed/10797171.

  86. Yoshiura T, Wu O, Sorensen AG. Advanced MR techniques: diffusion MR imaging, perfusion MR imaging, and spectroscopy. Neuroimaging Clin N Am. 1999;9(3):439-53. URL: http://www.ncbi.nlm.nih.gov/pubmed/10433637.

  87. Sorensen AG, Wu O, Copen WA, Davis TL, Gonzalez RG, Koroshetz WJ, Reese TG, Rosen BR, Wedeen VJ, Weisskoff RM. Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging. Radiology. 1999;212(3):785-92. URL: http://www.ncbi.nlm.nih.gov/pubmed/10478247.

  88. Sanchez del Rio M, Bakker D, Wu O, Agosti R, Mitsikostas DD, Ostergaard L, Wells WA, Rosen BR, Sorensen G, Moskowitz MA, Cutrer FM. Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia. 1999;19(8):701-7. URL: http://www.ncbi.nlm.nih.gov/pubmed/10570723.

  89. Ay H, Buonanno FS, Rordorf G, Schaefer PW, Schwamm LH, Wu O, Gonzalez RG, Yamada K, Sorensen GA, Koroshetz WJ. Normal diffusion-weighted MRI during stroke-like deficits. Neurology. 1999;52(9):1784-92. URL: http://www.ncbi.nlm.nih.gov/pubmed/10371524.

  90. Makris N, Worth AJ, Sorensen AG, Papadimitriou GM, Wu O, Reese TG, Wedeen VJ, Davis TL, Stakes JW, Caviness VS, Kaplan E, Rosen BR, Pandya DN, Kennedy DN. Morphometry of in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging. Ann Neurol. 1997;42(6):951-62. URL: http://www.ncbi.nlm.nih.gov/pubmed/9403488.

Book Chapters

  1. Wu O, Dijkhuizen RM. Strategies for stroke lesion prediction with MRI. In: Himmelreich U, Hoehn M, and Planas A, editors. In vivo Imaging of Animal Models: Stroke. New York: Springer, 2011.

  2. Wu O, Nentwich L, Chutinet A, Bayrlee A. Diffusion in acute stroke. In: Jones, DK, editor. Diffusion MRI: Theory, Methods, and Applications. New York: Oxford University Press; 2010.

  3. Makris N, Papadimitriou GM, Worth AJ, Jenkins BG, Garrido L, Sorensen AG, Wedeen VJ, Tuch DS, Wu O, Cudkowicz ME, Caviness VS Jr, Rosen BR, Kennedy DN. Diffusion Tensor Imaging. In: Neuropsychopharmacology: The Fifth Generation of Progress. New York, NY: Lippincott Williams & Wilkins; 2002. p 357-371.

Theses

  1. O. Wu. Predictive Models of Tissue Outcome in Acute Human Cerebral Ischemia using Diffusion and Perfusion Weighted MRI.
    Ph.D. Thesis in Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 2002.

  2. O. Wu. An Enhanced Reality System for the Great Outdoors.
    B.Sc. and M.Sc. Thesis in Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 1994.

  3. O. Wu. Winning the Hearts and Minds of the Chinese People: A study of Japanese, American, Kuomintang and Communist Propaganda 1937-1945.
    B.Sc. Thesis in History, Massachusetts Institute of Technology, 1992.

Ona Wu
ona_at_nmr.mgh.harvard.edu  
Athinoula A. Martinos Center JP Kistler Stroke Research Center
MGH/MIT/HMS MGH
Building 149, CNY-2301  
13th Street, Bldg 149 175 Cambridge Street Suite 300
Charlestown, MA 02129 Boston, MA 02114
USA USA
Tel: +1 617 643-3873  
Fax: +1 617 643-3939