Selected Publications
  1. Wu O, Østergaard L, Koroshetz WJ, Schwamm LH, O'Donnell J, Schaefer PW, Rosen BR, Weisskoff RM, Sorensen AG Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging Magn Reson Med. 2003 Oct;50(4):856-64.

  2. van Osch MJ, Vonken EJ, Wu O, Viergever MA, van der Grond J, Bakker CJ. Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI. Magn Reson Med. 2003 Sep;50(3):614-22.

  3. Wu O, Østergaard L, Weisskoff RM, Benner T, Rosen BR, Sorensen AG. Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix. Magn Reson Med. 2003 Jul;50(1):164-74.

  4. Dijkhuizen RM, Singhal AB, Mandeville JB, Wu O, Halpern EF, Finklestein SP, Rosen BR, Lo EH. Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci. 2003 Jan 15;23(2):510-7.

  5. Schaefer PW, Romero JM, Grant PE, Wu O, Sorensen AG, Koroshetz W, Gonzalez RG. Perfusion magnetic resonance imaging of acute ischemic stroke. Semin Roentgenol. 2002 Jul;37(3):230-6. Review.

  6. Schaefer PW, Romero JM, Grant PE, Wu O, Sorensen AG, Koroshetz W, Gonzalez RG. Diffusion magnetic resonance imaging of acute ischemic stroke. Semin Roentgenol. 2002 Jul;37(3):219-29. Review.

  7. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke. 2002 Aug;33(8):2100-4.

  8. Yamada K, Wu O, Gonzalez RG, Bakker D, Østergaard L, Copen WA, Weisskoff RM, Rosen BR, Yagi K, Nishimura T, Sorensen AG. Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods underlying vasculopathy. Stroke. 2002 Jan; 33(1):87-94.

  9. Dijkhuizen RM, Ren J, Mandeville JB, Wu O, Ozdag FM, Moskowitz MA, Rosen BR, Finklestein SP. Functional magnetic resonance imaging of reorganization in rat brain after stroke. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12766-71

  10. Copen WA, Schwamm LH, Gonzalez RG, Wu O, Harmarth CB, Schaefer PW, Koroshetz WJ, Sorensen AG. Ischemic Stroke: Effects of etiology and patient age on the time course fo the core apparent diffusion coefficient Radiology. 2001 Oct;221:27-34.

  11. Grant PE, He J, Halpern EF, Wu O, Schaefer PW, Schwamm LH, Budzik RF, Sorensen AG, Koroshetz WJ, Gonzalez RG. Frequency and clinical context of decreased apparent diffusion coefficient reversal in the human brain Radiology. 2001 Oct;221:43-50.

  12. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab. 2001 Aug;21(8):964-71.

  13. Yoshiura T, Wu O, Zaheer A, Reese TG, Sorensen AG. Highly diffusion-sensitized MRI of brain: dissociation of gray and white matter. Magn Reson Med. 2001 May;45(5):734-40.

  14. Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4687-92.

  15. Wu O, Koroshetz WJ, Østergaard L, Buonanno FS, Copen WA, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Sorensen AG. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging. Stroke. 2001 Apr;32(4):933-42.

  16. Østergaard L, Sorensen AG, Chesler DA, Weisskoff RM, Koroshetz WJ, Wu O, Gyldensted C, Rosen BR. Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. Stroke. 2000 May;31(5):1097-103.

  17. Sanchez del Rio M, Bakker D, Wu O, Agosti R, Mitsikostas DD, Østergaard L, Wells WA, Rosen BR, Sorensen G, Moskowitz MA, Cutrer FM. Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia. 1999 Oct;19(8):701-7.

  18. Sorensen AG, Wu O, Copen WA, Davis TL, Gonzalez RG, Koroshetz WJ, Reese TG, Rosen BR, Wedeen VJ,Weisskoff RM. Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging. Radiology. 1999 Sep;212(3):785-92.

  19. Yoshiura T, Wu O, Sorensen AG. Advanced MR techniques: diffusion MR imaging, perfusion MR imaging, and spectroscopy. Neuroimaging Clin N Am. 1999 Aug;9(3):439-53. Review.

  20. Ay H, Buonanno FS, Rordorf G, Schaefer PW, Schwamm LH, Wu O, Gonzalez RG, Yamada K, Sorensen GA, Koroshetz WJ. Normal diffusion-weighted MRI during stroke-like deficits. Neurology. 1999 Jun 10;52(9):1784-92.

  21. Makris N, Worth AJ, Sorensen AG, Papadimitriou GM, Wu O, Reese TG, Wedeen VJ, Davis TL, Stakes JW, Caviness VS, Kaplan E, Rosen BR, Pandya DN, Kennedy DN. Morphometry of in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging. Ann Neurol. 1997 Dec;42(6):951-62.

Selected Refereed Abstracts

  1. Wu O, Sumii T, Asahi M, Sasamata M, Sorensen AG, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM Assessment of treatment effects with multiparametric MRI-based predictive algorithms in a rat embolic stroke model Proceedings of the ISMRM Twelfth Scientific Meeting Kyoto, Japan, 14-16 May, 2004.

  2. Wu O, Christensen S, Hjort N, Rosa-Neto P, Mouridsen K, Rodell A, Dijkhuizen RM, Fiehler J, Rother J, Ostergaard L Can multiparametric MRI-based predictive algorithms assess efficacy of thrombolysis in hyperacute stroke patients? Proceedings of the ISMRM Twelfth Scientific Meeting Kyoto, Japan, 14-16 May, 2004.

  3. Wu O, Christensen S, Rosa-Neto P, Hjort N, Rodell A, Dijkhuizen RM, Fiehler J, Rother J, Ostergaard L Anatomy as a parameter in multiparametic MRI-based predictive algorithms Proceedings of the ISMRM Twelfth Scientific Meeting Kyoto, Japan, 14-16 May, 2004.

  4. Wu O, Koroshetz WJ, Ay H, O'Donnell J, Benner T, Ostergaard L, Lopez CJ, Zhu M, Dijkhuizen RM, Rosen BR, Sorensen AG Comparison of CBF deconvolution techniques using bolus tracking in the presence of delayed tracer arrival in acute stroke patients Proceedings of the ISMRM Twelfth Scientific Meeting Kyoto, Japan, 14-16 May, 2004.

  5. S. Christensen, O. Wu, K. Mouridsen, C. Gottrup, J. Fiehler, J. Rother, L. Ostergaard Local Arterial Input Functions based on Vascular Territories Proceedings of the ISMRM Twelfth Scientific Meeting Kyoto, Japan, 14-16 May, 2004.

  6. K. Mouridsen, O. Wu, S. Christensen, C. Gottrup, W. J. Koroshetz, A. G. Sorensen, L. Ostergaard. Prediction of Final Outcome in Acute Stroke Using Multivariate Adaptive Regression Splines Proceedings of the ISMRM Twelfth Scientific Meeting Kyoto, Japan, 14-16 May, 2004.

  7. J. van der Zijden, E. Hoogveld, A. van der Toorn, O. Wu, R. M. Dijkhuizen Mapping cortical projections after stroke in rat brain with in vivo manganese-enhanced MRI Proceedings of the ISMRM Twelfth Scientific Meeting Kyoto, Japan, 14-16 May, 2004.

  8. O Wu, S Christensen, N Hjort, MJP van Osch, RM Dijkhuizen, AG Sorensen, J Fiehler, J Rother, L Ostergaard Improved discrimination of salvageable and irreversibly infarcted tissue in acute stroke using perfusion-weighted MRI and delay-insensitive deconvolution methods ISMRM Workshop on Quantitative Cerebral Perfusion Imaging Using MRI: A Technical Perspective San Servolo, Venice, Italy, 21-23 March 2004.

  9. S. Christensen, O. Wu, K. Mouridsen, J. Fiehler, J Rother ,L. Ostergaard Semi-automated PWI analysis using vascular territory specific local arterial input functions ISMRM Workshop on Quantitative Cerebral Perfusion Imaging Using MRI: A Technical Perspective San Servolo, Venice, Italy, 21-23 March 2004.

  10. Wu O, Sumii T, Asahi M, Sasamata M, Sorensen AG, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM Predicting histological outcome using combined DWI & PWI in a rat embolic stroke model with delayed rt-PA treatment 29th AHA International Conference on Stroke and Cerebral Circulation San Diego, CA, Feb 5-7, 2004.

  11. Wu O, Ostergaard L, Benner T, Rosen BR, Weisskoff RM, Sorensen AG Tracer arrival timing insensitive technique for estimating CBF in PWI Proceedings of the ISMRM Eleventh Scientific Meeting Toronto, Canada, 10-16 May, 2003.

  12. Wu O, Schwamm LH, Weisskoff RM, Benner T, Copen WA, Koroshetz WJ, O'Donnell J, Ostergaard L, Rosen BR, Schaefer PW, Sorensen AG Measuring changes in blood-brain barrier permeability with perfusion-weighted MRI in human cerebral ischemia 28th AHA International Conference on Stroke and Cerebral Circulation Phoenix, AZ, Feb 13-15, 2003.

  13. O. Wu, L.H. Schwamm, W.J. Koroshetz, T. Benner, V.W. Pan, R.G. Gonzalez, B.R. Rosen, A.G. Sorensen Elevations in diffusion anisotropy in acute stroke related to age of ischmic insult and ADC reduction 27th AHA International Conference on Stroke and Cerebral Circulation San Antonio, TX, Feb 7-9, 2002.

  14. O. Wu, L.H. Schwamm, W.J. Koroshetz, A.G. Sorensen, et al Spatial-temporal cluster analysis of serial diffusion tensor MRI in human cerebral ischemia. Proceedings of the ISMRM Ninth Scientific Meeting Glasgow, Scotland, Apr 21-27, 2001.

  15. R.M. Dijkhuizen, M. Asahi, O. Wu, B.R. Rosen, E.H. Lo Delayed rt-PA treatment induces rapid blood-brain barrier breakdown and subsequent hemorrhagic transformation in a rat embolic stroke model. Proceedings of the ISMRM Ninth Scientific Meeting Glasgow, Scotland, Apr 21-27, 2001.

  16. L. Østergaard, D.A. Chesler, A. Gjedde, O. Wu, C. Gyldensted, B.R. Rosen, A.G. Sorensen Microscopic flow heterogeneity: its determination by PWI and role in cerebral oxygen metabolism. Proceedings of the ISMRM Ninth Scientific Meeting Glasgow, Scotland, Apr 21-27, 2001.

  17. A.G. Sorensen, O. Wu, K. Yamada, J.T. Vaughan MRI at 3.0 Tesla: Preliminary ex vivo animal and in vivo human safety studies. Proceedings of the ISMRM Ninth Scientific Meeting Glasgow, Scotland, Apr 21-27, 2001.

  18. O. Wu, L.H. Schwamm, W.J. Koroshetz, A.G. Sorensen, et al Heterogeneous spatial-temporal evolution of DWI/PWI in human cerebral ischemia. 26th AHA International Conference on Stroke and Cerebral Circulation. Ft. Lauderdale, Fl, Feb 14-16, 2001.

  19. O. Wu, A.G. Sorensen, W.J. Koroshetz, L.H. Schwamm, et al Spatial-Temporal Heterogeneity in the Pseudo-Normalization of ADC in Human Cerebral Ischemia. Proceedings of the ISMRM Eighth Scientific Meeting. Denver, CO, Apr 1-7, 2000.

  20. O. Wu, P.E. Grant, W.J. Koroshetz, A.G. Sorensen, et al Reversal of DWI Lesions May Be Associated with Increases in Anisotropy. Proceedings of the ISMRM Eighth Scientific Meeting. Denver, CO, Apr 1-7, 2000.

  21. RM Dijkhuizen, M Asahi, O Wu, L Østergaard, BR Rosen, EH Lo MRI of Incomplete Reperfusion, Enhanced Blood-Brain Barrier Damage and Hemorrhagic Transformation After Late rTPA Therapy in a Rat Embolic Stroke Model. 25th AHA International Conference on Stroke and Cerebral Circulation. New Orleans, LA. Feb 10-12, 2000.

  22. O. Wu, WJ Koroshetz, L Østergaard, et al Extension of MRI-Based Predictive Models of Infarction in Hyperacute Human Cerebral Ischemia. Proceedings of the ISMRM Seventh Scientific Meeting. Philadelphia, PA. May 24-28, 1999.

  23. D. Bakker, O. Wu, M. Sanchez del Rio, M. Cutrer, et al Spreading BOLD Deactivation During Spontaneous Migraine Aura. Proceedings of the ISMRM Seventh Scientific Meeting. Philadelphia, PA. May 24-28, 1999.

  24. AG Sorensen, O Wu, WA Copen, H Ay, RG Gonzalez, S Finkelstein Statistical Modeling of Acute Stroke MRI Data Can Suggest Therapeutic Efficacy. 24th AHA International Conference on Stroke and Cerebral Circulation. Nashville, TN. Feb 4-6, 1999.

  25. AG Sorensen, O Wu, WJ Koroshetz, et al Comparison of Statistical Models for Determination of Tissue Outcome in Acute Cerebral Ischemia. RSNA, 84th Scientific Assembly and Annual Meeting. Chicago,IL. Dec 1998.

  26. O. Wu, AG Sorensen, RG Gonzalez, L Østergaard, WJ Koroshetz, et al Evaluation of diffusion- and perfusion-based predictive models of tissue outcome in hyperacute human cerebral ischemia. Proceedings of the ISMRM Sixth Scientific Meeting. Sydney, Australia. April 18-24, 1998.

  27. O. Wu, AG Sorensen, RG Gonzalez, L Østergaard, WJ Koroshetz, et al. Assessment and Extension of Tissue Signature Models for Predicting Infarction in Hyperacute Human Focal Cerebral Ischemia. 23rd AHA International Joint Conference on Stroke and Cerebral Circulation. Orlando, FL. Feb 5-7, 1998.

  28. O. Wu, RM Weisskoff, WA Copen, RG Gonzalez, BR Rosen, AG Sorensen. Comparison of scalar metrics of anisotropy in ischemic human brain using diffusion weighted magnetic resonance imaging. Proceedings of the ISMRM Fifth Scientific Meeting. Vancouver, BC., Canada. April 12-18, 1997.
Invited Lectures

Theses

  1. O. Wu. Predictive Models of Tissue Outcome in Acute Human Cerebral Ischemia using Diffusion and Perfusion Weighted MRI.
    Ph.D. Thesis in Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 2002.

  2. O. Wu. An Enhanced Reality System for the Great Outdoors.
    B.Sc. and M.Sc. Thesis in Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 1994.

  3. O. Wu. Winning the Hearts and Minds of the Chinese People: A study of Japanese, American, Kuomintang and Communist Propaganda 1937-1945.
    B.Sc. Thesis in History, Massachusetts Institute of Technology, 1992.

Ona Wu
ona_at_invivonmr.uu.nl ona_at_pet.auh.dk ona_at_nmr.mgh.harvard.edu
Image Sciences Institute Center for Functionally Integrative Neuroscience Athinoula A. Martinos Center
University Medical Center Utrecht Århus University Hospital MGH/MIT/HMS
Experimental In Vivo NMR Center Building 30 Building 149, CNY-2301
Bolognalaan 50 Nørrebrograde 44 13th Street, Bldg 149
3584CJ Utrecht DK-8000 Arhus C Boston, MA 02129
the Netherlands Denmark USA
Tel: +31 30 253-5569   Tel: +1 617 726-5815
Fax: +31 30 253-5561 Fax: +45 8949 4400 Fax: +1 617 726-7422