Selected Publications
  1. Greer DM, Yang J, Scripko PD, Sims JR, Cash S, Wu O, Hafler JP, Schoenfeld DA, Furie KL. Clinical examination for prognostication in comatose cardiac arrest patients. Resuscitation. 2013 Aug 14. doi:pii: S0300-9572(13)00398-5. 10.1016/j.resuscitation.2013.07.028. [Epub ahead of print]

  2. Edlow BL, Giacino JT, Wu O. Functional MRI and outcome in traumatic coma. Curr Neurol Neurosci Rep. 2013 Sep;13(9):375. doi: 10.1007/s11910-013-0375-y.

  3. Edlow B, Giacino JT, Hirschberg RE, Gerrard J, Hochberg LR, Wu O. Unexpected recovery of function after severe traumatic brain injury: the limits of early neuroimaging-based outcome prediction. Neurocrit Care. 2013 Jul 17. [Epub ahead of print].

  4. Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, Grotta JC, Houser G, Jovin TG, Lees KR, Lev MH, Liebeskind DS, Luby M, Muir KW, Parsons MW, von Kummer R, Wardlaw JM, Wu O, et al. Acute Stroke Imaging Research Roadmap II. Stroke. 2013 Jul 16. [Epub ahead of print]

  5. Kamps MJA, Horn J, Oddo M, Fugate JE, Storm C, Cronberg T, Wijman CA, Wu O, Binnekade JM, Hoedemaekers CWE. Prognostication of neurologic outcome in cardiac arrest patients after mild therapeutic hypothermia: a meta-analysis of the current literature. Intensive Care Med. 2013 Jun 26. [Epub ahead of print]

  6. Wintermark M, Fiehler J, Kudo K, Liebeskind DS, Luby M, Michel P, Nogueira R, Parsons M, Sasaki M, Wardlaw J, Wu O, Zhang W, Zhu G, Warach S; for the Stroke Imaging Research (STIR) and VISTA-Imaging Investigators. International Survey of Acute Stroke Imaging Capabilities: We Need You! Stroke. 2013 Jun 11. [Epub ahead of print]

  7. Edlow BL, Haynes RL, Takahashi E, Klein JP, Cummings P, Benner T, Greer DM, Greenberg SM, Wu O, Kinney HC, Folkerth RD. Disconnection of the Ascending Arousal System in Traumatic Coma. J Neuropathol Exp Neurol. 2013 Jun;72(6):505-523.

  8. Bouts MJ, Tiebosch IA, van der Toorn A, Viergever MA, Wu O, Dijkhuizen RM. Early identification of potentially salvageable tissue with MRI-based predictive algorithms after experimental ischemic stroke. J Cereb Blood Flow Metab. 2013 Apr 10. doi: 10.1038/jcbfm.2013.51. [Epub ahead of print].

  9. Edlow BL, Wu O. Advanced neuroimaging in traumatic brain injury. Semin Neurol. 2012 Sep;32(4):374-400. doi: 10.1055/s-0032-1331810. Epub 2013 Jan 29.

  10. Greer DM, Scripko PD, Wu O, Edlow BL, Bartscher J, Sims JR, Camargo EE, Singhal AB, Furie KL. Hippocampal Magnetic Resonance Imaging Abnormalities in Cardiac Arrest are Associated with Poor Outcome. J Stroke Cerebrovasc Dis. 2012 Sep 17. pii: S1052-3057(12)00269-8. doi: 10.1016/j.jstrokecerebrovasdis. 2012.08.006. [Epub ahead of print].

  11. Cheng B, Ebinger M, Kufner A, Köhrmann M, Wu O, Kang DW, Liebeskind D, Tourdias T, Singer OC, Christensen S, Warach S, Luby M, Fiebach JB, Fiehler J, Gerloff C, Thomalla G; on behalf of the Stroke Imaging Repository (STIR) Investigators. Hyperintense Vessels on Acute Stroke Fluid-Attenuated Inversion Recovery Imaging: Associations With Clinical and Other MRI Findings. Stroke. 2012 Aug 28. [Epub ahead of print].

  12. Wu O, Lu J, Mandeville JB, Murata Y, Egi Y, Dai G, Marota JJ, Diwan I, Dijkhuizen RM, Kwong KK, Lo EH, Singhal AB. Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke. J Cereb Blood Flow Metab. 2012 Sep;32(9):1800-9. doi: 10.1038/jcbfm.2012.87. Epub 2012 Jun 27. PMCID: PMC3434635

  13. Song SS, Latour LL, Ritter CH, Wu O, Tighiouart M, Hernandez DA, Ku KD, Luby M, Warach S. A pragmatic approach using mri to treat ischemic strokes of unknown onset time in a thrombolytic trial. Stroke. 2012 Sep;43(9):2331-5. Epub 2012 Jun 12.

  14. Edlow BL, Takahashi E, Wu O, Benner T, Dai G, Bu L, Grant PE, Greer DM, Greenberg SM, Kinney HC, Folkerth RD. Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders. J Neuropathol Exp Neurol. 2012 Jun;71(6):531-546. PMCID: PMC3387430

  15. De Ipolyi AR, Wu O, Macklin EA, Schaefer PW, Schwamm LH, Gonzalez RG, Copen WA. Reliability of cerebral blood volume maps as a substitute for diffusion-weighted imaging in acute ischemic stroke. J Magn Reson Imaging. 2012 Nov;36(5):1083-7. doi: 10.1002/jmri.23740. Epub 2012 Jul 3.

  16. Wu O, Benner T, Roccatagliata L, Zhu M, Schaefer PW, Sorensen AG, Singhal AB. Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive models. Med Gas Res. 2012 Mar 9;2(1):5. PMCID: PMC3388462

  17. Arkink EB, Bleeker EJ, Schmitz N, Schoonman GG, Wu O, Ferrari MD, van Buchem MA, van Osch MJ, Kruit MC. Cerebral perfusion changes in migraineurs: a voxelwise comparison of interictal dynamic susceptibility contrast MRI measurements. Cephalalgia. 2012 Mar;32(4):279-88. Epub 2012 Jan 30.

  18. Greer DM, Yang J, Scripko PD, Sims J, Cash S, Kilbride R, Wu O, Schoenfeld D, Furie KL. Clinical examination for outcome prediction in non-traumatic coma. Crit Care Med. 2012 Apr;40(4):1150-6.

  19. Copen WA, Schaefer PW, Wu O. MR Perfusion Imaging in Acute Ischemic Stroke. Neuroimag Clin N Am. 2011;21(2):259-283. PMCID: PMC3135980

  20. Wu O, Schwamm LH, Sorensen AG. Imaging Stroke Patients with Unclear Onset Times. Neuroimag Clin N Am. 2011;21(2):327-344. PMCID: PMC3109317

  21. Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, Kim JS, Breuer L, Singer OC, Warach S, Christensen S, Treszl A, Forkert ND, Galinovic I, Rosenkranz M, Engelhorn T, Köhrmann M, Endres M, Kang D, Dousset V, Sorensen AG, Liebeskind DS, Fiebach JB, Fiehler J, Gerloff C. MRI identifies acute ischemic stroke patients within a time window for thrombolysis – a multicentre observational study on the predictive value of DWI-FLAIR mismatch for the identification of acute ischemic stroke patients ≤4.5 h of symptom onset (PRE-FLAIR). Lancet Neurol. 2011 Nov;10(11):978-86. Epub 2011 Oct 4.

  22. Kwong KK, Wu O, Chan ST, Nelissen K, Kholodov M, Chesler DA. Early time points perfusion imaging: Relative time of arrival, maximum derivatives and fractional derivatives. Neuroimage. 2011 Aug 1;57(3):979-90. Epub 2011 May 12. PMCID: PMC3129483

  23. Kimberly WT, Wu O, Arsava EM, Garg P, Ji R, Vangel M, Singhal AB, Ay H, Sorensen AG. Lower hemoglobin correlates with larger stroke volumes in acute ischemic stroke. Cerebrovasc Dis Extra 2011 Jan-Dec;1(1):44-53. Epub 2011 May 17. PMCID: PMC3343751

  24. Wu O, Batista LM, Lima FO, Vangel MG, Furie KL, Greer DM. Predicting clinical outcome in comatose cardiac arrest patients using early non-contrast CT. Stroke. 2011;42:985-992. PMCID: PMC3107844

  25. Gokcay F, Arsava EM, Baykaner T, Vangel M, Garg P, Wu O, Singhal AB, Furie KL, Sorensen AG, Ay H. Age-Dependent Susceptibility to Infarct Growth in Women. Stroke. 2011;42:947-951. PMCID: PMC3066257

  26. Kwong KK, Reese TG, Nelissen K, Wu O, Chan ST, Benner T, Mandeville JB, Foley M, Vanduffel W, Chesler DA. Early time points perfusion imaging. Neuroimage. 2011 Jan 15;54(2):1070-82. Epub 2010 Sep 17. PMCID: PMC2997123

  27. Wu O, Dijkhuizen RM, Sorensen AG. Multiparametric MR imaging of Brain Disorders. Top Magn Reson Imaging. 2011 Apr;21(2):129-38. PMCID: PMC3319343.

  28. Wu O, Dijkhuizen RM. Strategies for stroke lesion prediction with MRI. In: Himmelreich U, Hoehn M, and Planas A, editors. In vivo Imaging of Animal Models: Stroke. New York: Springer, 2011.

  29. Wu O, Nentwich L, Chutinet A, Bayrlee A. Diffusion in acute stroke. In: Jones, DK, editor. Diffusion MRI: Theory, Methods, and Applications. New York: Oxford University Press; 2010.

  30. Emmer BJ, van Osch MJ, Wu O, Steup-Beekman GM, Steens SC, Huizinga TW, van Buchem MA, van der Grond J. Perfusion MRI in neuro-psychiatric systemic lupus erthemathosus. J Magn Reson Imaging. 2010 Aug;32(2):283-8.

  31. Fujiwara N, Murata Y, Arai K, Egi Y, Lu J, Wu O, Singhal AB, Lo EH. Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. BMC Neurosci. 2009 Jul 15;10:79. PMCID: PMC2714858

  32. Wu O, Sorensen AG, Benner T, Furie KL, Greer DM. Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imaging. Radiology. 2009 Jul;252(1):173-81. Epub 2009 May 6.

  33. Christensen S, Mouridsen K, Wu O, Hjort N, Karstoft H, Thomalla G, Röther J, Fiehler J, Kucinski T, Østergaard L. Comparison of 10 perfusion MRI parameters in 97 sub-6-hour stroke patients using voxel-based receiver operating characteristics analysis. Stroke. 2009 Jun;40(6):2055-61.

  34. Copen WA, Rezai Gharai L, Barak ER, Schwamm LH, Wu O, Kamalian S, Gonzalez RG, Schaefer PW. Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion. Radiology. 2009 Mar;250(3):878-86.

  35. Christensen S, Calamante F, Hjort N, Wu O, Blankholm AD, Desmond P, Davis S, Ostergaard L. Inferring origin of vascular supply from tracer arrival timing patterns using bolus tracking MRI. J Magn Reson Imaging. 2008 Jun;27(6):1371-81.

  36. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute Stroke Imaging Research Roadmap. Stroke. 2008 May;39(5):1621-8. Epub 2008 Apr 10.

  37. Ay H, Arsava EM, Rosand J, Furie KL, Singhal AB, Schaefer PW, Wu O, Gonzalez RG, Koroshetz WJ, Sorensen AG. Severity of Leukoaraiosis and Susceptibility to Infarct Growth in Acute Stroke. Stroke. 2008 Mar 13.

  38. Ay H, Arsava EM, Vangel M, Oner B, Zhu M, Wu O, Singhal A, Koroshetz WJ, Sorensen AG. Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke research. Stroke. 2008 Apr;39(4):1171-6.

  39. Hjort N, Wu O, AshkanianM, Sølling C, Mouridsen K, Christensen S, Gyldensted C, Andersen G, Østergaard L. MRI Detection of Early Blood-Brain Barrier Disruption: Parenchymal Enhancement Predicts Focal Hemorrhagic Transformation after Thrombolysis. Stroke. 2008 Mar;39(3):1025-8.

  40. van der Zijden JP, Bouts MJ, Wu O, Roeling TA, Bleys RL, van der Toorn A, Dijkhuizen RM. Manganese-enhanced MRI of brain plasticity in relation to functional recovery after experimental stroke. J Cereb Blood Flow Metab. 2008 Apr;28(4):832-40. Epub 2007 Nov 7.

  41. van der Zijden JP, Wu O, van der Toorn A, Roeling TP, Bleys RL, Dijkhuizen RM. Changes in neuronal connectivity after stroke in rats as studied by serial manganese-enhanced MRI. Neuroimage. 2007;34(4):1650-7.

  42. Wu O, Sumii T, Asahi M, Sasamata M, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM. Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models. J Cereb Blood Flow Metab. 2007;27(1):196-204.

  43. Makris N, Papadimitriou GM, van der Kouwe A, Kennedy DN, Hodge SM, Dale AM, Benner T, Wald LL, Wu O, Tuch DS, Caviness VS, Moore TL, Killiany RJ, Moss MB, Rosene DL. Frontal connections and cognitive changes in normal aging rhesus monkeys: A DTI study. Neurobiol Aging. 2006.

  44. Wu O, Christensen S, Hjort N, Dijkhuizen RM, Kucinski T, Fiehler J, Thomalla G, Rother J, Ostergaard L. Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI. Brain. 2006;129(Pt 9):2384-93.

  45. Hjort N, Christensen S, Solling C, Ashkanian M, Wu O, Rohl L, Gyldensted C, Andersen G, Ostergaard L. Ischemic injury detected by diffusion imaging 11 minutes after stroke. Ann Neurol. 2005;58(3):462-5.

  46. Ay H, Koroshetz WJ, Benner T, Vangel MG, Wu O, Schwamm LH, Sorensen AG. Transient ischemic attack with infarction: a unique syndrome? Ann Neurol. 2005;57(5):679-86.

  47. Gottrup C, Thomsen K, Locht P, Wu O, Sorensen AG, Koroshetz WJ, Ostergaard L. Applying instance-based techniques to prediction of final outcome in acute stroke. Artif Intell Med. 2005;33(3):223-36.

  48. Wu O, Ostergaard L, Sorensen AG. Technical aspects of perfusion-weighted imaging. Neuroimaging Clin N Am. 2005;15(3):623-37, xi.

  49. van Eijsden P, Notenboom RG, Wu O, de Graan PN, van Nieuwenhuizen O, Nicolay K, Braun KP. In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat. Brain Res. 2004;1030(1):11-8.

  50. Ozsunar Y, Grant PE, Huisman TA, Schaefer PW, Wu O, Sorensen AG, Koroshetz WJ, Gonzalez RG. Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2. AJNR Am J Neuroradiol. 2004;25(5):699-705.

  51. Huisman TA, Schwamm LH, Schaefer PW, Koroshetz WJ, Shetty-Alva N, Ozsunar Y, Wu O, Sorensen AG. Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. AJNR Am J Neuroradiol. 2004;25(3):370-6.

  52. Wu O, Østergaard L, Koroshetz WJ, Schwamm LH, O'Donnell J, Schaefer PW, Rosen BR, Weisskoff RM, Sorensen AG Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging Magn Reson Med. 2003 Oct;50(4):856-64.

  53. van Osch MJ, Vonken EJ, Wu O, Viergever MA, van der Grond J, Bakker CJ. Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI. Magn Reson Med. 2003 Sep;50(3):614-22.

  54. Wu O, Østergaard L, Weisskoff RM, Benner T, Rosen BR, Sorensen AG. Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix. Magn Reson Med. 2003 Jul;50(1):164-74.

  55. Dijkhuizen RM, Singhal AB, Mandeville JB, Wu O, Halpern EF, Finklestein SP, Rosen BR, Lo EH. Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci. 2003 Jan 15;23(2):510-7.

  56. Schaefer PW, Romero JM, Grant PE, Wu O, Sorensen AG, Koroshetz W, Gonzalez RG. Perfusion magnetic resonance imaging of acute ischemic stroke. Semin Roentgenol. 2002 Jul;37(3):230-6. Review.

  57. Schaefer PW, Romero JM, Grant PE, Wu O, Sorensen AG, Koroshetz W, Gonzalez RG. Diffusion magnetic resonance imaging of acute ischemic stroke. Semin Roentgenol. 2002 Jul;37(3):219-29. Review.

  58. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke. 2002 Aug;33(8):2100-4.

  59. Yamada K, Wu O, Gonzalez RG, Bakker D, Østergaard L, Copen WA, Weisskoff RM, Rosen BR, Yagi K, Nishimura T, Sorensen AG. Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods underlying vasculopathy. Stroke. 2002 Jan; 33(1):87-94.

  60. Dijkhuizen RM, Ren J, Mandeville JB, Wu O, Ozdag FM, Moskowitz MA, Rosen BR, Finklestein SP. Functional magnetic resonance imaging of reorganization in rat brain after stroke. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12766-71

  61. Copen WA, Schwamm LH, Gonzalez RG, Wu O, Harmarth CB, Schaefer PW, Koroshetz WJ, Sorensen AG. Ischemic Stroke: Effects of etiology and patient age on the time course fo the core apparent diffusion coefficient Radiology. 2001 Oct;221:27-34.

  62. Grant PE, He J, Halpern EF, Wu O, Schaefer PW, Schwamm LH, Budzik RF, Sorensen AG, Koroshetz WJ, Gonzalez RG. Frequency and clinical context of decreased apparent diffusion coefficient reversal in the human brain Radiology. 2001 Oct;221:43-50.

  63. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab. 2001 Aug;21(8):964-71.

  64. Yoshiura T, Wu O, Zaheer A, Reese TG, Sorensen AG. Highly diffusion-sensitized MRI of brain: dissociation of gray and white matter. Magn Reson Med. 2001 May;45(5):734-40.

  65. Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4687-92.

  66. Wu O, Koroshetz WJ, Østergaard L, Buonanno FS, Copen WA, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Sorensen AG. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging. Stroke. 2001 Apr;32(4):933-42.

  67. Østergaard L, Sorensen AG, Chesler DA, Weisskoff RM, Koroshetz WJ, Wu O, Gyldensted C, Rosen BR. Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. Stroke. 2000 May;31(5):1097-103.

  68. Sanchez del Rio M, Bakker D, Wu O, Agosti R, Mitsikostas DD, Østergaard L, Wells WA, Rosen BR, Sorensen G, Moskowitz MA, Cutrer FM. Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia. 1999 Oct;19(8):701-7.

  69. Sorensen AG, Wu O, Copen WA, Davis TL, Gonzalez RG, Koroshetz WJ, Reese TG, Rosen BR, Wedeen VJ,Weisskoff RM. Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging. Radiology. 1999 Sep;212(3):785-92.

  70. Yoshiura T, Wu O, Sorensen AG. Advanced MR techniques: diffusion MR imaging, perfusion MR imaging, and spectroscopy. Neuroimaging Clin N Am. 1999 Aug;9(3):439-53. Review.

  71. Ay H, Buonanno FS, Rordorf G, Schaefer PW, Schwamm LH, Wu O, Gonzalez RG, Yamada K, Sorensen GA, Koroshetz WJ. Normal diffusion-weighted MRI during stroke-like deficits. Neurology. 1999 Jun 10;52(9):1784-92.

  72. Makris N, Worth AJ, Sorensen AG, Papadimitriou GM, Wu O, Reese TG, Wedeen VJ, Davis TL, Stakes JW, Caviness VS, Kaplan E, Rosen BR, Pandya DN, Kennedy DN. Morphometry of in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging. Ann Neurol. 1997 Dec;42(6):951-62.

Theses

  1. O. Wu. Predictive Models of Tissue Outcome in Acute Human Cerebral Ischemia using Diffusion and Perfusion Weighted MRI.
    Ph.D. Thesis in Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 2002.

  2. O. Wu. An Enhanced Reality System for the Great Outdoors.
    B.Sc. and M.Sc. Thesis in Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 1994.

  3. O. Wu. Winning the Hearts and Minds of the Chinese People: A study of Japanese, American, Kuomintang and Communist Propaganda 1937-1945.
    B.Sc. Thesis in History, Massachusetts Institute of Technology, 1992.

Ona Wu
ona_at_nmr.mgh.harvard.edu ona_at_invivonmr.uu.nl ona_at_pet.auh.dk
Athinoula A. Martinos Center Image Sciences Institute Center for Functionally Integrative Neuroscience
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