Funding Source: NIH 5P41RR014075-07; Partners Collaborative Grant (Kikinis & Stufflebeam)
Using of MEG & fMRI for creating spatiotemporal maps of visual and auditory language. Research is also in collaboration with Dr. Alex Golby at BWH:
Funded Research
Presurgical Brain Mapping in Epilepsy
Funding Sources: The Harvard Clinical and Translational Science Center Grant, Mental Illness and Neuroscience Discovery (MIND) Institute, Partners Radiology Collaborative Research Grant, NIH 5P41RR014075-07, 5R01NS037462-07 (Belliveau Lab)
This project aims to explore and optimize the integration of fMRI, magnetoencephalography (MEG), and electroencephalography (EEG) with high spatial resolution anatomic MRI for detecting subtle structural and functional abnormalities in the cerebral cortex, white matter, and deep gray nuclei. We are currently using invasive measurements in humans to correlate with our non-invasive measurements. In particular, we are using a functional connectivity MRI (fcMRI) to perform eloquent cortex mapping. The project long term goal is to improve the surgical outcome in epilepsy patients.
Resting State fcMRI for Presurgical Mapping
Funding Sources: The Harvard Catalyst Pilot Grant Award (Stufflebeam and Buckner).
This project uses resting state functional connectivity to map eloquent cortex in the human brain using epilepsy and brain tumor patients, including lateralizating and localizing motor and language neural networks.
Spectral Spatiotemporal Imaging
Funding Sources: NIH 5P41RR014075-07, 5R01NS037462-07 (Belliveau Lab)
Spectral spatiotemporal imaging is used to image rhythmic brain activity, both at rest and during activation tasks.
Auditory Information Processing in Schizophrenia
Funding Source: National Institutes of Health 5K08MH067966-02, Mental Illness and Neuroscience Discovery (MIND) Institute
Research Description: Understanding early auditory processing may reveal underlying mechanisms in schizophrenia. The study involves imaging schizophrenic patients using MRI, fMRI and MEG/EEG using a variety of experimental paradigms. Currently we are studying how rhythmic brain activity in the posterior superior temporal gyrus is affected in schizophrenia. We are also investigating mechanisms that lead to abnormal auditory mismatch in schizophrenia.
Visual Information Processing in Schizophrenia
Funding Source: NARSAD (Young Investigator Award)
Research Description: This project aims to understand how the large-scale neural network between the frontal lobe and the occipito-parietal lobe is involved in visual motion processing and smooth pursuit eye movements (SPEM), both in healthy subjects and schizophrenic subjects.
Stufflebeam Lab in the News: Boston Globe Article
Funded Collaborative Research Projects
Dynamic Inverse Solutions for Multimodal Imaging
Funding Source: 1R01EB006385-01A1 ( Dr Boas )
Develop and integrate state-space model based on imaging, neurophysiology, and anatomy to better integrate multiple imaging technologies.
Audiovisual Integration
Funding Source: 5T32DC000020-17 (through Dr. Nadol)
Understanding how visual information influences auditory processing using simple phonetic stimuli. The long term goal is to understand how this can be used to improve audition in hearing impaired patients or to improve the success of cochlear implants. This project is in collaboration with Dr. Donald Eddington of the MEEI.
Optical imaging
Funding Source: NIH 5P41RR014075-07
Acquiring simultaneous diffusion optical tomography with MEG. This is in collaboration with David Boas and Maria Angela Franceschini (originally with Ilkka Nissilä) in the Photon Migration Laboratory at the Martinos Center.
Presurgical Mapping of Eloquent Cortex with MEG/EEG and fMRI
Funding Source: NIH 5P41RR014075-07; Partners Collaborative Grant (Kikinis & Stufflebeam)
Using of MEG & fMRI for creating spatiotemporal maps of visual and auditory language. Research is also in collaboration with Dr. Alex Golby at BWH: