Napadow Lab

Aversive symptomatology, such as pain and nausea, leads to significant morbidity and makes up the bulk of out-patient visits to physicians. Many of these symptoms are perceptual states with no clear etiology and there is a lack of understanding of the brain circuitry supporting such perceptions. A better understanding of this brain circuitry will aid greatly in developing novel therapeutic interventions, which are also lacking. The Napadow laboratory has pioneered the application of non-invasive neuroimaging techniques to better understand the brain circuitry underlying aversive perceptual states, and to better understand existing conventional and non-conventional therapies, such as acupuncture, which patients turn to when mainstream medical approaches have failed.

 

Research
Interests

- Neuroimaging of the Central Autonomic and Pain Networks

- Neuro-correlates of acupuncture imaged with fMRI and MEG
- Cortical plasticity in Carpal Tunnel Syndrome treated by acupuncture

- Brain mechanisms underlying acupuncture anti-pruritic, anti-nausea and analgesic effects

 

fruity brain image by Kyle Bean

 

 

 

PI: Vitaly Napadow, PhD LicAc

Athinoula A. Martinos Center for Biomedical Imaging

Associate Professor

Harvard Medical School

Description: Description: Macintosh HD:Users:vitaly:Documents:LabAdmin:Photos:vitaly_COLOR.jpg

 

Lab Personnel:

 

Junior Faculty

Marco Loggia, PhD

 

Post-doctoral Research Fellows

Jieun Kim, PhD

Yumi Maeda, DDS PhD

Richard Lin, ScD

 

Research Assistants

Alexandra Libby, BS

James Sheehan, MS

Jessica Gerber, MAc

 

Visiting Faculty

Ronald Garcia, MD PhD

Florian Beissner, PhD

Hyungjun Kim, PhD

 

 

____________________________________________________________________________________

Primary Research

 

2014

Ichesco E, Schmidt-Wilcke T, Bhavsar R, Clauw DJ, Peltier SJ, Kim J, Napadow V, Hampson JP, Kairys AE, Williams DA, Harris RE. Altered resting state connectivity of the insular cortex in individuals with fibromyalgia. J Pain. 2014 in press. PMID: 24815079

[pdf / abstract]

 

Kim J, Van Dijk K, Libby A, Napadow V. Frequency-dependent relationship between resting state fMRI signal power and head motion is localized within distributed association networks.

Brain Connectivity. 2014, 4(1):30-9. PMID: 24117373

[pdf / abstract]

 

Loggia ML, Berna C, Kim J, Cahalan CM, Gollub RL, Wasan AD, Harris RE, Edwards RR*, Napadow V*. Disrupted brain circuitry for pain-related reward/punishment in fibromyalgia. Arthritis and Rheumatism. 2014, 66(1):203-12.

[pdf / abstract]

 

Maeda Y, Kettner N, Holden J, Lee J, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Im J, Libby A, Mezzacappa P, Morse LR, Park K, Audette J, Tommerdahl M, Napadow V. Functional deficits in carpal tunnel syndrome reflect reorganization of primary somatosensory cortex. Brain. 2014, in press. PMID: 24740988

[pdf / abstract]

 

Napadow V, Li A, Loggia M, Kim J, Schalock PC, Lerner E, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F. The Brain Circuitry Mediating Anti-pruritic Effects of Acupuncture. Cerebral Cortex, 2014. 24(4):873-82. PMCID: PMC3948489

[pdf / abstract]

 

2013

Beissner F, Meissner K, Bar K, Napadow V. The autonomic brain – An ALE meta-analysis for central processing of autonomic function. Journal of Neuroscience. 2013, 33(25): 10503-11. PMCID: PMC3685840

[pdf / abstract]

 

Dolman AJ, Loggia ML, Edwards RR, Gollub RL, Kong J, Napadow V, Wasan AD. Phenotype Matters: The Absence of a Positive Association between Cortical Thinning and Chronic Low Back Pain when Controlling for Salient Clinical Variables. Clin J Pain. 2013, in press. PMID: 24135900

[pdf / abstract]

 

Hadjikhani N, Boshyan J, Ward N, Napadow V, Maeda Y, Mainero C. The missing link: enhanced connectivity between amygdala and visceroceptive cortex in migraine. Cephalalgia. 2013, 33(15):1264-8. PMCID: PMC3797870

[pdf / abstract]

 

Harris RE*, Napadow V*, Huggins JP, Pauer L, Kim J, Hampson J, Sundgren PC, Foerster B, Petrou M, Schmidt-Wilcke T, Clauw DJ. Pregabalin Rectifies Aberrant Brain Chemistry, Connectivity, and Functional Response in Chronic Pain Patients. Anesthesiology, 2013. 119(6):1453-64.

[pdf / abstract]

 

Harte SE, Clauw DJ, Napadow V, Harris RE. Pressure Pain Sensitivity and Insular Combined Glutamate and Glutamine (Glx) Are Associated with Subsequent Clinical Response to Sham But Not Traditional Acupuncture in Patients Who Have Chronic Pain. Medical Acupuncture. 2013. 25(2): 154-160.

[pdf / abstract]

 

Kim J, Loggia ML, Edwards R, Wasan AD, Gollub RL, Napadow V. Sustained deep-tissue pain alters functional brain connectivity. Pain. 2013, 154(8): 1343-51. PMCID: PMC3700646

[pdf / abstract]

 

Kong J, Spaeth RB, Wey HY, Cheetham A, Cook AH, Jensen K, Tan Y, Liu H, Wang D, Loggia ML, Napadow V, Smoller JW, Wasan AD, Gollub RL. S1 is associated with chronic low back pain: a functional and structural MRI study. Mol Pain. 2013; 9(1):43. PMCID: PMC3765748

[pdf / abstract]

 

Loggia ML, Kim J, Gollub R, Vangel M, Kirsch I, Kong J, Wasan A, Napadow V. Default Mode Network Connectivity Encodes Clinical Pain: An Arterial Spin Labeling Study. Pain. 2013, 154(1):24-33. PMCID: PMC3534957

[pdf / abstract]

 

Maeda Y, Kettner N, Lee J, Sheehan J, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Im J, Libby A, Mezzacappa P, Morse LR, Park K, Audette J, Napadow V. Acupuncture evoked response in somatosensory cortex reflects peripheral nerve pathology of carpal tunnel syndrome. Medical Acupuncture. 2013. 25(4): 275-284.

[pdf / abstract]

 

Maeda Y, Kettner N, Lee J, Sheehan J, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Im J, Libby A, Mezzacappa P, Morse LR, Park K, Audette J, Napadow V. Acupuncture evoked response in somatosensory and prefrontal cortices predicts immediate pain reduction in carpal tunnel syndrome. eCAM. 2013, In press. PMCID: PMC3703406

[pdf / abstract]

 

Maeda Y, Kettner N, Sheehan J, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Mezzacappa P, Morse LR, Audette J, Napadow V. Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology. Neuroimage (Amst.). 2013, 2: 313-319. PMCID: PMC3689649

[pdf / abstract]

 

Napadow V, Sheehan J, Kim J, LaCount L, Park K, Kaptchuk T, Rosen BR, Kuo B. The Brain Circuitry Underlying the Temporal Evolution of Nausea in Humans. Cerebral Cortex, 2013 23(4):806-13. PMCID: PMC3593575

[pdf / abstract]

 

Napadow V, Sheehan J, Kim J, Dassatti A, Thurler AH, Surjanhata B, Vangel M, Makris N, Schaechter JD, Kuo B. Brain white matter microstructure is associated with susceptibility to motion-induced nausea. Neurogastroenterol Motil. 2013. 25(5):448-e303. PMCID: PMC3631298

[pdf / abstract]

 

2012

As-Sanie S, Harris RE, Napadow V, Kim J, Neshewat G, Kairys A, Williams D, Clauw DJ, Schmidt-Wilcke T. Changes in regional gray matter volume in women with chronic pelvic pain: a voxel-based morphometry study. Pain. 2012. 153(5): 1006-14. PMCID: PMC3613137

[pdf / abstract]

 

Dhond RP, Ruzich E, Witzel T, Maeda Y, Malatesta C, Morse LR, Audette J, Hamalainen M, Kettner N, Napadow V. Spatiotemporal Mapping Cortical Neuroplasticity in Carpal Tunnel Syndrome. Brain. 2012, 135(Pt 10):3062-73. PMCID: PMC3470711

[pdf / abstract]

 

Huang W, Pach D, Napadow V, Park K, Long X, Neumann J, Maeda Y, Nierhaus T, Liang F, Witt CM. Characterizing acupuncture stimuli using brain imaging with FMRI - a systematic review and meta-analysis of the literature. PLoS One. 2012. 7(4):e32960. PMCID: PMC3322129

[pdf / abstract]

 

Loggia ML, Edwards RR, Kim J, Vangel MG, Wasan A, Gollub RL, Harris RE, Park K, Napadow V. Disentangling linear and nonlinear brain responses to evoked deep tissue pain. Pain. 2012, 153(10):2140-51. PMCID: PMC3445769

[pdf / abstract]

 

Napadow V, Kim J, Clauw DJ, Harris RE. Decreased Intrinsic Brain Connectivity is Associated with Reduced Clinical Pain in Fibromyalgia. Arthritis & Rheumatism. 2012. 64(7): 2398-403. PMCID: PMC3349799

[pdf / abstract]

 

Napadow V, Robert R Edwards, Christine M Cahalan, George Mensing, Seth Greenbaum, Assia Valovska, Ang Li, Jieun Kim, Yumi Maeda, Kyungmo Park, Ajay D. Wasan. Evoked Pain Analgesia in Chronic Pelvic Pain Patients using Respiratory-gated Auricular Vagal Afferent Nerve Stimulation. Pain Medicine. 2012. 13(6): 777-89. PMCID: PMC3376238

[pdf / abstract]

 

Napadow V, Jeungchan Lee, Jieun Kim; Stephen Cina; Yumi Maeda; Riccardo Barbieri; Richard E Harris, Norman Kettner, Kyungmo Park. Brain Correlates of Phasic Autonomic Response to Acupuncture Stimulation: an event-related fMRI study. Human Brain Mapping. 2012. 34(10):2592-606. PMCID: PMC3646924

[pdf / abstract]

 

Pfab F, Kirchner MT, Huss-Marp J, Schuster T, Schalock PC, Fuqin J, Athanasiadis GI, Behrendt H, Ring J, Darsow U, Napadow V. Acupuncture compared to oral antihistamine for type I hypersensitivity itch and skin response in adults with atopic dermatitis – a patient and examiner blinded, randomized, placebo-controlled, crossover trial. Allergy. 2012. 67(4): 566-73. PMCID: PMC3303983

[pdf / abstract]

 

2011

Witzel T, Napadow V, Kettner NW, Vangel MG, Hamalainen MS, Dhond RP. Differences in Cortical Response to Acupressure and Electroacupuncture Stimuli. BMC Neuroscience, 2011. 12(1): 73. PMCID: PMC3162932

[pdf / abstract]

 

Wasan AD, Loggia ML, Chen LQ, Napadow V, Kong J, Gollub RL. Neural Correlates of Chronic Low Back Pain Measured by Arterial Spin Labeling. Anesthesiology. 2011, 115(2): 364-374. PMCID: PMC3286828

[pdf / abstract]

 

LaCount LT, Barbieri R, Park K, Kim J, Brown EN, Kuo B, Napadow V. Static and dynamic autonomic response with increasing nausea perception. Aviat Space Environ Med. 2011. 82(4):424-33. PMCID: PMC3137518

[pdf / abstract]

 

Pfab F, Winhard M, Nowak-Machen M, Napadow V, Irnich D, Pawlik M, Bein T, Hansen E. Acupuncture in critically ill patients improves delayed gastric emptying: a randomized controlled trial. Anesth Analg. 2011. 112(1):150-5. PMID: 21081772

[pdf / abstract]

 

2010

Napadow V, LaCount L, Park K, As-Sanie S, Clauw DJ, Harris RE. Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis & Rheumatism. 2010. 62(8):2545-55. PMCID: PMC2921024

[pdf / abstract]

 

Hui KK, Napadow V, Liu J, Li M, Marina O, Nixon EE, Claunch JD, LaCount L, Sporko T, Kwong KK. Monitoring acupuncture effects on human brain by FMRI. J Vis Exp. 2010 (38): 1190. PMID: 20379133

[pdf / abstract / movie]

 

2009

Harris RE, Sundgren PC, Craig AD, Kirshenbaum E, Sen A, Napadow V, Clauw DJ. Elevated Insular Glutamate in Fibromyalgia Is Associated With Experimental Pain. Arthritis & Rheumatism. 2009; 60(10): 3146–3152. PMID: 19790053

[pdf / abstract]

 

Hui KK, Marina O, Claunch JD, Nixon EE, Fang J, Liu J, Li M, Napadow V, Vangel M, Makris N, Chan ST, Kwong KK, Rosen BR. Acupuncture mobilizes the brain's default mode and its anti-correlated network in healthy subjects. Brain Res. 2009; 1287:84-103. PMID: 19559684.

[pdf / abstract]

 

Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on μ-Opioid Receptors (MORs). Neuroimage. 2009; 47(3): 1077-85. PMID: 19501658.

[pdf / abstract]

 

Napadow V, Dhond RP, Kim J, LaCount L, Vangel M, Harris RE, Kettner N, Park K. Brain encoding of acupuncture sensation - coupling on-line rating with fMRI. Neuroimage. 2009; 47(3):1055-65. PMID: 19500677.

[pdf / abstract]

 

Napadow V, Dhond RP, Park K, Kim J, Makris N, Kwong KK, Harris RE, Purdon P, Kettner N, Hui KKS. Time-Variant fMRI Activity in the Brainstem and Higher Structures in Response to Acupuncture. Neuroimage. 2009, 47(1):289-301.

[pdf / abstract]

 

2008

Napadow V, Dhond RP, Conti G, Makris N, Brown EN, Barbieri R. Brain Correlates of Autonomic Modulation: Combining Heart Rate Variability with fMRI. Neuroimage. 2008, 42(1):169-77.

[pdf / abstract]

 

Dhond RP, Yeh C, Park K, Kettner N, Napadow V. Acupuncture Modulates Resting State Connectivity in Default and Sensorimotor Brain Networks. Pain. 2008, 136(3):407-18.

[pdf / abstract]

 

Dhond RP, Witzel T, Hamalainen M, Kettner N, Napadow V. Spatiotemporal Mapping the Neural Correlates of Acupuncture with MEG. J Altern Complement Med. 2008, 14(6):679-88.

[pdf / abstract]

 

2007

Napadow V, N Kettner, J Liu, M Li, KK Kwong, M Vangel, N Makris, J Audette, Hui KKS. Hypothalamus and Amygdala Response to Acupuncture Stimuli in Carpal Tunnel Syndrome. Pain. 2007, 130(3):254-66.

[pdf / abstract]

 

Napadow V, Liu J, Li M, Kettner N, Ryan A, Kwong KK, Hui KKS, Audette J. Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupuncture. Hum Brain Mapp. 2007, Mar;28(3):159-71.
[pdf / abstract]

 

Hui KK, Nixon EE, Vangel MG, Liu J, Marina O, Napadow V, Hodge SM, Rosen BR, Makris N, Kennedy DN. Characterization of the "Deqi" Response in Acupuncture. BMC Complement Altern Med. 2007 Oct 31;7(1):33

[pdf / abstract]

 

2006

Gilbert RJ, Wedeen VJ, Magnusson LH, Benner T, Wang R, Dai G, Napadow VJ, Roche KK. Three-dimensional myoarchitecture of the bovine tongue demonstrated by diffusion spectrum magnetic resonance imaging with tractography. Anat Rec A Discov Mol Cell Evol Biol. 2006 Nov;288(11):1173-82.

[pdf / abstract]

 

Napadow V, Dhond R, Kennedy D, Hui KKS, Makris N. Automated Brainstem Co-registration (ABC) for MRI. Neuroimage. 2006, Sep 32(3):1113-9.
[pdf / abstract]

 

Gilbert RJ, Magnusson LH, Napadow V, Benner T, Wang R, Wedeen V. Mapping complex myoarchitecture in the bovine tongue with diffusion spectrum magnetic resonance imaging. Biophysical Journal. 2006, Aug 1; 91(3):1014-22.

[pdf / abstract]

 

Napadow V, Kettner N, Ryan A, Kwong KK, Audette J, Hui KKS. Somatosensory Cortical Plasticity in Carpal Tunnel Syndrome - a Cross-sectional fMRI Evaluation. Neuroimage, 2006, Jun 31(2):520-30.
[pdf / abstract]


2005

Napadow V, Dhond RP, Purdon P, Kettner N, Makris N, Kwong KK, Hui KKS. Correlating acupuncture fMRI in the human brainstem with heart rate variability. Conf Proc IEEE Eng Med Biol Soc. 2005; 5:4496-9.

[pdf / abstract]

 

Hui KK, Liu J, Marina O, Napadow V, Haselgrove C, Kwong KK, Kennedy DN, Makris N. The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. Neuroimage. 2005 Sep;27(3):479-96.
[pdf / abstract]

 

Gilbert RJ, Napadow VJ. Three-dimensional muscular architecture of the human tongue determined in vivo with diffusion tensor magnetic resonance imaging. Dysphagia. 2005 Winter;20(1):1-7.
[pdf / abstract]

 

Napadow V, Makris N, Liu J, Kettner NW, Kwong KK, Hui KK. Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Hum Brain Mapp. 2005 Mar;24(3):193-205.
[pdf / abstract]

 

2004

Napadow V, Liu J, Kaptchuk TJ. A systematic study of acupuncture practice: acupoint usage in an outpatient setting in Beijing, China. Complement Ther Med. 2004 Dec;12(4):209-16.
[pdf / abstract]

 

Napadow V, Kaptchuk TJ. Patient characteristics for outpatient acupuncture in Beijing, China. J Altern Complement Med. 2004 Jun;10(3):565-72.
[pdf / abstract]

 

2002

Napadow V, Kamm RD, Gilbert RJ.  A biomechanical model of sagittal tongue bending. Journal of Biomechanical Engineering. 2002; 124 (5):547-56.
[pdf / abstract]

 

2001

Napadow V, Mai V, Bankier AA, Gilbert RJ, Edelman R, Chen Q.  Determination of regional pulmonary parenchymal strain during normal respiration using spin inversion tagged magnetization MRI. Journal of Magnetic Resonance Imaging. 2001; 13 (3):467-74.
[pdf / abstract]

 

Chen Q, Mai V, Bankier AA, Napadow V, Gilbert RJ, Edelman R.  An ultra-fast MR grid tagging sequence for assessment of local mechanical properties of the lungs. Magnetic Resonance in Medicine. 2001; 45 (1):24-8.
[pdf / abstract]

 

Napadow V, Wedeen VJ, Chen Q, Mai V, So PTC, Gilbert RJ.  Quantitative analysis of 3D-resolved lingual fiber architecture in intact tissue with diffusion tensor MRI and two-photon microscopy.  Biophysical Journal. 2001; 80 (6):2968-75.
[pdf / abstract]


Wedeen V, Reese TG, Napadow V, Gilbert RJ.  Demonstration of primary and secondary muscle fiber architecture of the Bovine tongue by diffusion tensor MRI.  Biophysical Journal. 2001; 80 (2):1024-8.
[pdf / abstract]


1999

Napadow V, Chen Q, Wedeen VJ, Gilbert RJ.  Biomechanical basis for lingual muscular deformation during swallowing.  American Journal of Physiology. 1999; 40 (3):G695-G701.
[pdf / abstract]

 

Napadow V, Chen Q, Wedeen VJ, Gilbert RJ.  Intramural mechanics of the human tongue in association with physiological deformation.  Journal of  Biomechanics. 1999; 32 (1):1-12.
[pdf / abstract]

 

 

 

Reviews

2013

Pfab F, Schalock PC, Napadow V, Athanasiadis GI, Yosipovitch G, Ring J. Complementary integrative approach for treating pruritus. Dermatol Ther. 2013 Mar-Apr;26(2):149-56. PMID: 23551371

[pdf / abstract]

2012

Loggia ML, Napadow V. Multi-parameter autonomic-based pain assessment: More is more? Pain. 2012, 153(9):1779-80. PMID: 22633682

[pdf / abtract]

Pfab F, Valet M, Napadow V, Tölle TR, Behrendt H, Ring J, Darsow U. Itch and the brain. Chem Immunol Allergy. 2012;98:253-65. PMID: 22767068

[pdf / abstract]

Pfab F, Nowak-Machen M, Napadow V, Fleckenstein J. Alternatives to prokinetics to move the pylorus and colon. Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):166-173. PMID: 22234164

[pdf / abstract]

2011

Rosen BR, Napadow V. Quantitative markers for neuropsychiatric disease: give it a rest. Radiology. 2011. 259(1):17-9. PMID: 21436093

[pdf / abstract]

Langevin HM, Wayne PM, Macpherson H, Schnyer R, Milley RM, Napadow V, Lao L, Park J, Harris RE, Cohen M, Sherman KJ, Haramati A, Hammerschlag R. Paradoxes in acupuncture research: strategies for moving forward. Evid Based Complement Alternat Med. 2011. 180805. PMID: 20976074

[pdf / abstract]

2009

Wayne PM, Hammerschlag R, Langevin HM, Napadow V, Park JJ, Schnyer RN. Resolving paradoxes in acupuncture research: a roundtable discussion. J Altern Complement Med. 2009. 15(9):1039-44. PMID: 19757981

[pdf / abstract]

Gray MA, Minati L, Harrison NA, Gianaros PJ, Napadow V, Critchley HD. Physiological recordings: basic concepts and implementation during functional Magnetic Resonance Imaging. Neuroimage. 2009; 47(3):1105-15. PMID: 19460445.

[pdf / abstract]

2008

Napadow V, Ahn A, Longhurst J, Lao L, Stener-Victorin E, Harris R, Langevin HM. The status and future of acupuncture mechanism research.

J Altern Complement Med. 2008 Sep;14(7):861-9. PMID: 18803495

[pdf / abstract]

2007

Dhond R, Kettner N, Napadow V. Do the neural correlates of acupuncture and placebo effects differ? Pain. 2007 Mar 128(1-2):8-12.

[pdf / abstract]

Dhond RP, Kettner N, Napadow V. Neuroimaging Acupuncture Effects in the Human Brain. J Altern Complement Med. 2007, 13(6):603-16.

[pdf / abstract]

Kong J, Gollub R, Huang T, Polich G, Napadow V, Hui K, Vangel M, Rosen B, Kaptchuk TJ. Acupuncture de qi, from qualitative history to quantitative measurement. J Altern Complement Med. 2007 Dec;13(10):1059-70.

[pdf / abstract]

Gilbert RJ, Napadow VJ, Gaige TA, Wedeen VJ. Anatomical basis of lingual hydrostatic deformation. J Exp Biol. 2007 Dec;210(Pt 23):4069-82.

[pdf / abstract]

2006

Napadow V, Webb M, Pearson N, Hammerschlag R. Neurobiological Correlates of Acupuncture: November 17-18, 2005. J Altern Complement Med. 2006 Nov;12(9):931-5.

[pdf / abstract]

Langevin HM, Hammerschlag R, Lao L, Napadow V, Schnyer RN, Sherman KJ. Controversies in acupuncture research: selection of controls and outcome measures in acupuncture clinical trials. J Altern Complement Med. 2006 Dec;12(10):943-53.

[pdf / abstract]