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Vitaly Napadow, Ph.D., Lic.Ac.
Athinoula A.
Martinos Center for Biomedical Imaging Assistant Professor Department of Radiology Massachusetts General Hospital Harvard Medical School 149 Thirteenth
Street, Room 2301 Charlestown, MA 02129 (617) 724-3402 (work) (617) 726-7422 (fax) email:
vitaly-at-nmr.mgh.harvard.edu |
Research
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Neuroimaging of the Central Autonomic and Pain Networks - Neuro-correlates of acupuncture imaged with fMRI and MEG -
Brain mechanisms underlying acupuncture anti-nausea and analgesic effects |
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Primary Research
2012
Napadow V, Li A, Loggia M, Kim J, Schalock PC, Lerner E, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F. The Brain Circuitry Mediating Anti-pruritic Effects of Acupuncture. Cerebral Cortex, 2012. In press.
[pdf / abstract]
Loggia ML, Edwards RR, Kim J, Vangel
MG, Wasan A, Gollub RL, Harris RE, Park K, Napadow V. Disentangling linear and
nonlinear brain responses to evoked deep tissue pain. Pain. 2012,
in press. PMID: 22883925
[pdf / abstract]
Loggia ML, Kim J, Gollub R, Vangel M, Kirsch I, Kong J, Wasan A, Napadow V. Default Mode Network Connectivity Encodes Clinical Pain:
An Arterial Spin Labeling Study. Pain. 2012, in press.
[pdf / abstract]
Dhond RP, Ruzich
E, Witzel T, Maeda Y, Malatesta
C, Morse LR, Audette J, Hamalainen
M, Kettner N, Napadow
V. Spatiotemporal Mapping Cortical Neuroplasticity in Carpal Tunnel
Syndrome. Brain. 2012, in press. PMID: 23043143
[pdf / abstract]
Napadow V,
Kim J, Clauw DJ, Harris RE. Decreased Intrinsic Brain
Connectivity is Associated with Reduced Clinical Pain in Fibromyalgia. Arthritis & Rheumatism. 2012. 64(7): 2398-403. PMID:
22294427
Pfab F, Kirchner MT, Huss-Marp J, Schuster
T, Schalock PC, Fuqin J, Athanasiadis GI, Behrendt H, Ring
J, Darsow U, Napadow
V. Acupuncture compared to oral antihistamine for type I hypersensitivity
itch and skin response in adults with atopic dermatitis – a patient and
examiner blinded, randomized, placebo-controlled, crossover trial. Allergy.
2012. 67(4): 566-73. PMID: 22313287
Napadow V, Robert R Edwards, Christine M Cahalan, George Mensing, Seth Greenbaum, Assia Valovska, Ang Li, Jieun Kim, Yumi Maeda, Kyungmo Park, Ajay D. Wasan. Evoked Pain Analgesia in
Chronic Pelvic Pain Patients using Respiratory-gated Auricular Vagal Afferent
Nerve Stimulation. Pain Medicine. 2012. 13(6): 777-89. PMID: 22568773
Napadow V, Jeungchan
Lee, Jieun Kim; Stephen Cina;
Yumi Maeda; Riccardo Barbieri;
Richard E Harris, Norman Kettner, Kyungmo
Park. Brain Correlates of Phasic Autonomic Response to Acupuncture Stimulation:
an event-related fMRI study. Human Brain Mapping.
2012. In press.
Napadow V, Sheehan J, Kim J, LaCount L, Park K, Kaptchuk T, Rosen BR, Kuo B. The Brain Circuitry Underlying the
Temporal Evolution of Nausea in Humans. Cerebral
Cortex, 2012. In press.
As-Sanie S, Harris
RE, Napadow V, Kim J, Neshewat G, Kairys A, Williams D,
Clauw DJ, Schmidt-Wilcke T.
Changes in regional gray matter volume in women with chronic pelvic pain: a
voxel-based morphometry study. Pain. 2012. 153(5): 1006-14. PMID: 22387096
Huang W, Pach D, Napadow V, Park K, Long X, Neumann J, Maeda Y, Nierhaus T, Liang F, Witt CM. Characterizing acupuncture stimuli using brain imaging with FMRI - a systematic review and meta-analysis of the literature. PLoS One. 2012. 7(3): in press. PMID: 22496739
2011
Witzel T, Napadow V, Kettner NW, Vangel MG, Hamalainen MS, Dhond RP. Differences in Cortical Response to Acupressure and Electroacupuncture Stimuli. BMC Neuroscience, 2011.
12(1): 73. PMID: 21794103
Wasan AD, Loggia ML, Chen LQ, Napadow V, Kong J, Gollub
RL. Neural Correlates of Chronic Low Back Pain Measured by Arterial Spin
Labeling. Anesthesiology. 2011, in press. PMID:
21720241
LaCount LT, Barbieri R, Park K, Kim J, Brown
EN, Kuo B, Napadow
V. Static and dynamic autonomic response with increasing nausea perception.
Aviat
Space Environ Med. 2011. 82(4):424-33. PMID:
21485400
Pfab F, Winhard M, Nowak-Machen
M, Napadow V, Irnich
D, Pawlik M, Bein T, Hansen
E. Acupuncture in critically ill patients improves delayed gastric emptying: a
randomized controlled trial. Anesth Analg. 2011. 112(1):150-5. PMID:
21081772
2010
Napadow V, LaCount
L, Park K, As-Sanie S, Clauw
DJ, Harris RE. Intrinsic brain connectivity in fibromyalgia is associated with
chronic pain intensity. Arthritis & Rheumatism.
2010. 62(8):2545-55. PMID: 20506181
Hui KK, Napadow
V, Liu J, Li M, Marina O, Nixon EE, Claunch JD, LaCount L, Sporko T, Kwong KK. Monitoring acupuncture effects on human brain by FMRI. J Vis
Exp. 2010 (38): 1190. PMID: 20379133
2009
Harris RE, Sundgren PC, Craig AD, Kirshenbaum E, Sen
A, Napadow V, Clauw DJ. Elevated Insular Glutamate in Fibromyalgia Is Associated With Experimental Pain. Arthritis & Rheumatism. 2009; 60(10):
3146–3152. PMID: 19790053
Hui KK, Marina O, Claunch JD, Nixon EE, Fang
J, Liu J, Li M, Napadow V, Vangel M, Makris N, Chan ST, Kwong KK, Rosen BR. Acupuncture mobilizes the brain's
default mode and its anti-correlated network in healthy subjects. Brain Res. 2009; 1287:84-103. PMID:
19559684.
Harris RE, Zubieta
JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are
differentiated by their effects on μ-Opioid Receptors (MORs). Neuroimage. 2009; 47(3): 1077-85. PMID: 19501658.
Napadow V, Dhond
RP, Kim J, LaCount L, Vangel
M, Harris RE, Kettner N, Park K. Brain encoding of
acupuncture sensation - coupling on-line rating with fMRI. Neuroimage. 2009; 47(3):1055-65. PMID: 19500677.
Napadow V, Dhond
RP, Park K, Kim J, Makris N, Kwong
KK, Harris RE, Purdon P, Kettner N, Hui KKS. Time-Variant fMRI Activity in
the Brainstem and Higher Structures in Response to Acupuncture. Neuroimage. 2009,
47(1):289-301.
2008
Napadow V, Dhond
RP, Conti G, Makris N, Brown EN, Barbieri
R. Brain Correlates of Autonomic Modulation: Combining Heart Rate Variability
with fMRI. Neuroimage.
2008, 42(1):169-77.
Dhond RP, Yeh C, Park K, Kettner
N, Napadow V. Acupuncture Modulates
Resting State Connectivity in Default and Sensorimotor Brain Networks. Pain. 2008, 136(3):407-18.
Dhond RP, Witzel T, Hamalainen M, Kettner N, Napadow V.
Spatiotemporal Mapping the Neural Correlates of Acupuncture with MEG. J Altern
Complement Med. 2008, 14(6):679-88.
2007
Napadow V, N Kettner,
J Liu, M Li, KK Kwong, M Vangel,
N Makris, J Audette, Hui KKS. Hypothalamus and Amygdala
Response to Acupuncture Stimuli in Carpal Tunnel Syndrome. Pain. 2007, 130(3):254-66.
Napadow V, Liu J, Li M, Kettner
N, Ryan A, Kwong KK, Hui
KKS, Audette J. Somatosensory cortical plasticity in
carpal tunnel syndrome treated by acupuncture. Hum Brain Mapp. 2007, Mar;28(3):159-71.
[pdf / abstract]
Hui KK,
Nixon EE, Vangel MG, Liu J, Marina O, Napadow V, Hodge SM, Rosen BR, Makris N, Kennedy DN. Characterization of the
"Deqi" Response in Acupuncture. BMC
Complement Altern Med. 2007 Oct 31;7(1):33
2006
Gilbert RJ, Wedeen VJ, Magnusson LH, Benner T,
Wang R, Dai G, Napadow VJ, Roche KK.
Three-dimensional myoarchitecture of the bovine
tongue demonstrated by diffusion spectrum magnetic resonance imaging with
tractography. Anat Rec A Discov Mol Cell Evol Biol. 2006 Nov;288(11):1173-82.
Napadow V, Dhond R,
Kennedy D, Hui KKS, Makris
N. Automated Brainstem Co-registration (ABC) for MRI. Neuroimage. 2006, Sep 32(3):1113-9.
[pdf / abstract]
Gilbert RJ,
Magnusson LH, Napadow V, Benner T,
Wang R, Wedeen V. Mapping complex myoarchitecture
in the bovine tongue with diffusion spectrum magnetic resonance imaging. Biophysical Journal. 2006, Aug 1; 91(3):1014-22.
Napadow V, Kettner N, Ryan A, Kwong
KK, Audette J, Hui KKS. Somatosensory
Cortical Plasticity in Carpal Tunnel Syndrome - a Cross-sectional fMRI
Evaluation. Neuroimage,
2006, Jun 31(2):520-30.
[pdf / abstract]
2005
Napadow V, Dhond RP,
Purdon P, Kettner N, Makris
N, Kwong KK, Hui KKS. Correlating acupuncture fMRI in the human brainstem with heart rate
variability. Conf Proc
IEEE Eng Med Biol Soc.
2005; 5:4496-9.
Hui KK, Liu J, Marina O, Napadow V, Haselgrove
C, Kwong KK, Kennedy DN, Makris
N. The integrated response of the human cerebro-cerebellar
and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI.
Neuroimage.
2005 Sep;27(3):479-96.
[pdf /
abstract]
Gilbert RJ, Napadow VJ. Three-dimensional muscular
architecture of the human tongue determined in vivo with diffusion tensor
magnetic resonance imaging. Dysphagia.
2005 Winter;20(1):1-7.
[pdf /
abstract]
Napadow V, Makris N, Liu J, Kettner NW, Kwong KK, Hui KK. Effects of electroacupuncture versus manual acupuncture on the human
brain as measured by fMRI. Hum Brain Mapp. 2005 Mar;24(3):193-205.
[pdf / abstract]
2004
Napadow V, Liu J,
Kaptchuk TJ. A systematic study of acupuncture practice: acupoint usage in an
outpatient setting in Beijing, China. Complement
Ther Med. 2004 Dec;12(4):209-16.
[pdf /
abstract]
Napadow V, Kaptchuk
TJ. Patient characteristics for outpatient acupuncture in
Beijing, China. J Altern Complement Med. 2004 Jun;10(3):565-72.
[pdf / abstract]
2002
Napadow V, Kamm RD, Gilbert RJ. A biomechanical model of sagittal tongue bending. Journal of Biomechanical
Engineering. 2002; 124 (5):547-56.
[pdf /
abstract]
2001
Napadow V, Mai V, Bankier
AA, Gilbert RJ, Edelman R, Chen Q. Determination of regional pulmonary parenchymal strain during normal
respiration using spin inversion tagged magnetization MRI. Journal of Magnetic Resonance Imaging.
2001; 13 (3):467-74.
[pdf / abstract]
Chen Q, Mai V, Bankier AA, Napadow V, Gilbert RJ, Edelman R. An ultra-fast MR grid tagging sequence
for assessment of local mechanical properties of the lungs. Magnetic Resonance in Medicine. 2001; 45 (1):24-8.
[pdf
/ abstract]
Napadow V, Wedeen VJ, Chen Q, Mai V, So
PTC, Gilbert RJ. Quantitative analysis of 3D-resolved lingual fiber architecture in
intact tissue with diffusion tensor MRI and two-photon microscopy. Biophysical Journal. 2001; 80 (6):2968-75.
[pdf / abstract]
Wedeen V, Reese TG, Napadow V, Gilbert RJ. Demonstration of primary and secondary
muscle fiber architecture of the Bovine tongue by diffusion tensor MRI. Biophysical Journal. 2001; 80 (2):1024-8.
[pdf / abstract]
1999
Napadow V, Chen Q, Wedeen VJ, Gilbert RJ. Biomechanical
basis for lingual muscular deformation during swallowing. American Journal of
Physiology. 1999; 40 (3):G695-G701.
[pdf / abstract]
Napadow V, Chen Q, Wedeen VJ, Gilbert RJ. Intramural mechanics of the human tongue in association with
physiological deformation. Journal
of Biomechanics. 1999; 32 (1):1-12.
[pdf / abstract]
Reviews
2012
Pfab F, Nowak-Machen
M, Napadow V, Fleckenstein J.
Alternatives to prokinetics to move the pylorus and
colon. Curr Opin Clin Nutr Metab
Care. 2012 Mar;15(2):166-173. PMID: 22234164
[pdf / abstract]
2011
Rosen BR, Napadow V. Quantitative markers for
neuropsychiatric disease: give it a rest. Radiology. 2011. 259(1):17-9. PMID: 21436093
Langevin HM, Wayne
PM, Macpherson H, Schnyer R, Milley
RM, Napadow V, Lao L, Park J, Harris
RE, Cohen M, Sherman KJ, Haramati A, Hammerschlag R. Paradoxes in acupuncture research:
strategies for moving forward. Evid Based Complement Alternat Med. 2011.
180805. PMID: 20976074
2009
Wayne PM, Hammerschlag R, Langevin
HM, Napadow V, Park JJ, Schnyer RN. Resolving paradoxes in acupuncture
research: a roundtable discussion. J Altern Complement Med. 2009.
15(9):1039-44. PMID: 19757981
[pdf / abstract]
Gray MA, Minati L, Harrison NA, Gianaros
PJ, Napadow V, Critchley
HD. Physiological recordings: basic concepts and implementation during
functional Magnetic Resonance Imaging. Neuroimage. 2009;
47(3):1105-15. PMID: 19460445.
2008
Napadow V, Ahn A, Longhurst J, Lao L, Stener-Victorin
E, Harris R, Langevin HM. The
status and future of acupuncture mechanism research.
J Altern
Complement Med. 2008
Sep;14(7):861-9. PMID: 18803495
2007
Dhond R, Kettner N, Napadow V. Do the
neural correlates of acupuncture and placebo effects differ? Pain. 2007 Mar 128(1-2):8-12.
Dhond RP, Kettner N, Napadow V.
Neuroimaging Acupuncture Effects in the Human Brain. J Altern Complement Med. 2007, 13(6):603-16.
Kong J, Gollub R, Huang T, Polich G, Napadow V, Hui K, Vangel
M, Rosen B, Kaptchuk TJ. Acupuncture de qi, from
qualitative history to quantitative measurement. J Altern Complement Med. 2007 Dec;13(10):1059-70.
Gilbert RJ, Napadow VJ, Gaige
TA, Wedeen VJ. Anatomical basis of
lingual hydrostatic deformation. J
Exp Biol. 2007 Dec;210(Pt 23):4069-82.
[pdf / abstract]
2006
Napadow V, Webb M, Pearson
N, Hammerschlag R. Neurobiological Correlates of Acupuncture:
November 17-18, 2005. J Altern Complement Med. 2006 Nov;12(9):931-5.
Langevin HM, Hammerschlag R, Lao L, Napadow
V, Schnyer RN, Sherman KJ. Controversies in
acupuncture research: selection of controls and outcome measures in acupuncture
clinical trials. J Altern
Complement Med. 2006 Dec;12(10):943-53.
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Grant Support |
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Ongoing
Research Support |
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Brain Plasticity in Carpal Tunnel Syndrome and
its Response to Acupuncture (NIH)
R01AT004714 (PI: Napadow) This study will characterize brain plasticity in Carpal Tunnel
Syndrome and will determine how this central fMRI biomarker is modulated by
acupuncture. This study will also investigate the behavioral consequences of
maladaptive cortical plasticity in this disease population. |
9/15/08
– 5/31/13 |
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Neuroimaging
Acupuncture on Brain Activity in Chronic low Back Pain (NIH)
P01AT006663 (PI: Rosen, Project 1 Leader: Napadow) The central goal of this "Center of Excellence for
Research on Complementary and Alternative Medicine" is to apply
neuroimaging to explore the central mechanisms of acupuncture action in
chronic low back pain (cLBP), a clinically significant disorder for which
effective modes of treatment are currently lacking. |
9/01/11 – 6/30/16 |
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An
fMRI study of expectancy on acupuncture treatment outcomes in knee OA (NIH)
R01AT005280 (PI: Gollub/Kaptchuk) The goal of this study is to elucidate the functional
neurocircuitry associated with endogenous inhibition of pain perception in
patients with chronic knee pain. |
2/01/10 – 3/31/15 |
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Completed
Research Support |
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Brain Plasticity in Carpal Tunnel Syndrome and
its Response to Acupuncture (NIH)
R01AT004714-02S1 (PI: Napadow) This
competitive revision supplement will add the testing for cortical adaptation
metrics to the existing Carpal Tunnel Syndrome neuroimaging study. These
previously validated metrics will explore potential S1 disinhibition in CTS
patients using biobehavioral testing. |
9/30/09
– 9/29/11 |
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Neuroimaging
Acupuncture Effects on Human Brain Activity (NIH)
P01AT002048 (PI: Rosen) The central goal of this "Center of Excellence for
Research on Complementary and Alternative Medicine" application is to
investigate the neurobiology of acupuncture in humans and animal models using
PET and fMRI. |
9/26/03 – 5/31/11 |
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Exploring
Neurocircuitry of Acupuncture Action with fMRI (NIH)
K01AT002166 (PI: Napadow) The goals of this study are to understand the neurobiology
involved with the full duration acupuncture treatment, thereby promoting the
development of this ancient healing technique into evidence –based
medicine. |
6/1/04 – 5/30/09 |
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FMRI
of Autonomic Regulation with Acupuncture (NIH)
F05AT003770 (PI: Park) The goals of this study are to decipher the brain
correlates for acupuncture modulation of the autonomic nervous system using
multi-modal techniques combining functional MRI with physiological
monitoring. |
9/30/06 - 9/29/09 |
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Clinical Experience
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2005-present |
Acupuncturist, Pain
Management Center, Brigham and Women's Hospital, Chestnut Hill, MA |
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2004-present |
Vitality Acupuncture (private practice) |
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2002-2003 |
Beijing Hospital of Traditional
Chinese Medicine, Wan Jing Hospital, Beijing, China |
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2001-2002 |
NESA Clinic, Watertown, MA; Aids Care
Project, Boston, MA; Dimock Hospital, Boston, MA 504 hours supervised clinical
internship |
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Education
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2001 |
Doctorate of
Philosophy, Division of Health Science and
Technology |
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1998 |
Master of
Science, Mechanical Engineering |
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1995 |
Bachelor of
Science, Mechanical Engineering |
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2002 |
Master of
Acupuncture, Chinese and Japanese Style Acupuncture |
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Awards |
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2000 |
Finalist,
Schnitzer Prize for the Visual Arts |
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