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Vitaly
Napadow, Ph.D., Lic.Ac.
Athinoula A.
Martinos Center for Biomedical Imaging Assistant
Professor Department
of Radiology Massachusetts General Hospital Harvard
Medical School 149 Thirteenth
Street, Room 2301 Charlestown,
MA 02129 (617) 724-3402 (work) (617) 726-7422 (fax) email: vitaly-at-nmr.mgh.harvard.edu |
{---------Reviews---------Primary Research------}
Research
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- Neuroimaging of the Central Autonomic and Pain
Networks - Neuro-correlates of
acupuncture imaged with fMRI and MEG - Brain mechanisms underlying acupuncture
anti-nausea and analgesic effects |
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Reviews
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2011 |
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Rosen
BR, Napadow V. Quantitative
markers for neuropsychiatric disease: give it a rest. Radiology. 2011. 259(1):17-9. PMID: 21436093 [pdf / abstract] |
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Langevin HM, Wayne PM, Macpherson H, Schnyer R, Milley RM, Napadow V, Lao L, Park J, Harris RE,
Cohen M, Sherman KJ, Haramati A, Hammerschlag R. Paradoxes
in acupuncture research: strategies for moving forward. Evid Based Complement Alternat
Med. 2011. 180805. PMID: 20976074 |
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2009 |
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Wayne
PM, Hammerschlag R, Langevin
HM, Napadow V, Park JJ, Schnyer RN. Resolving
paradoxes in acupuncture research: a roundtable discussion. J Altern
Complement Med. 2009. 15(9):1039-44. PMID:
19757981 [pdf / abstract] |
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Gray MA, Minati L,
Harrison NA, Gianaros PJ, Napadow V, Critchley HD. Physiological
recordings: basic concepts and implementation during functional Magnetic
Resonance Imaging. Neuroimage. 2009; 47(3):1105-15. PMID: 19460445. |
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2008 |
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Napadow V, Ahn
A, Longhurst J, Lao L, Stener-Victorin
E, Harris R, Langevin HM. The status and future of
acupuncture mechanism research. J Altern
Complement Med. 2008 Sep;14(7):861-9. PMID: 18803495 |
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2007 |
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Dhond R, Kettner N, Napadow V. Do the neural correlates of
acupuncture and placebo effects differ? Pain.
2007 Mar 128(1-2):8-12. |
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Dhond RP, Kettner N, Napadow V. Neuroimaging Acupuncture
Effects in the Human Brain. J Altern Complement Med. 2007, 13(6):603-16.
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Kong J, Gollub R, Huang T, Polich G, Napadow V, Hui K, Vangel
M, Rosen B, Kaptchuk TJ. Acupuncture de
qi, from qualitative history to quantitative measurement. J Altern
Complement Med. 2007 Dec;13(10):1059-70. |
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Gilbert
RJ, Napadow VJ, Gaige TA, Wedeen VJ. Anatomical
basis of lingual hydrostatic deformation. J
Exp Biol. 2007 Dec;210(Pt 23):4069-82. [pdf / abstract] |
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2006 |
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Napadow V, Webb M, Pearson N, Hammerschlag R.
Neurobiological Correlates of Acupuncture: November 17-18, 2005. J Altern
Complement Med. 2006 Nov;12(9):931-5. |
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Langevin HM, Hammerschlag
R, Lao L, Napadow V, Schnyer RN, Sherman KJ. Controversies in acupuncture research:
selection of controls and outcome measures in acupuncture clinical trials. J Altern
Complement Med. 2006 Dec;12(10):943-53. |
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Primary
Research
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2011 |
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Witzel T, Napadow V,
Kettner NW, Vangel MG, Hamalainen MS, Dhond RP.
Differences in Cortical Response to Acupressure and Electroacupuncture
Stimuli. BMC Neuroscience, 2011. 12(1): 73. PMID: 21794103 |
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Wasan AD, Loggia ML, Chen LQ, Napadow V, Kong J, Gollub RL. Neural
Correlates of Chronic Low Back Pain Measured by Arterial Spin Labeling.
Anesthesiology. 2011, in press. PMID: 21720241 |
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LaCount LT, Barbieri R, Park K,
Kim J, Brown EN, Kuo B, Napadow V. Static and dynamic autonomic response with increasing
nausea perception. Aviat Space Environ Med. 2011.
82(4):424-33. PMID: 21485400 |
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Pfab F, Winhard M, Nowak-Machen M, Napadow
V, Irnich D, Pawlik
M, Bein T, Hansen E. Acupuncture in critically ill
patients improves delayed gastric emptying: a randomized controlled trial. Anesth Analg. 2011. 112(1):150-5. PMID: 21081772 |
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2010 |
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Napadow V,
LaCount L, Park K, As-Sanie
S, Clauw DJ, Harris RE. Intrinsic brain
connectivity in fibromyalgia is associated with chronic pain intensity.
Arthritis & Rheumatism. 2010. 62(8):2545-55.
PMID: 20506181 |
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Hui KK, Napadow
V, Liu J, Li M, Marina O, Nixon EE, Claunch JD,
LaCount L, Sporko T, Kwong KK. Monitoring acupuncture effects on human brain
by FMRI. J Vis Exp. 2010 (38): 1190. PMID: 20379133 |
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2009 |
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Harris RE, Sundgren PC, Craig AD,
Kirshenbaum E, Sen A, Napadow V, Clauw DJ. Elevated Insular Glutamate in Fibromyalgia Is
Associated With Experimental Pain. Arthritis & Rheumatism. 2009; 60(10):
3146–3152. PMID: 19790053 |
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Hui KK, Marina O, Claunch JD,
Nixon EE, Fang J, Liu J, Li M, Napadow
V, Vangel M, Makris
N, Chan ST, Kwong KK, Rosen BR. Acupuncture mobilizes
the brain's default mode and its anti-correlated network in healthy subjects.
Brain Res. 2009; 1287:84-103. PMID:
19559684. |
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Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture
and placebo (sham) acupuncture are differentiated by their effects on μ-Opioid Receptors
(MORs). Neuroimage.
2009; 47(3): 1077-85. PMID: 19501658. |
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Napadow V,
Dhond RP, Kim J, LaCount
L, Vangel M, Harris RE, Kettner
N, Park K. Brain encoding of acupuncture sensation - coupling on-line rating
with fMRI. Neuroimage.
2009; 47(3):1055-65. PMID: 19500677. |
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Napadow V,
Dhond RP, Park K, Kim J, Makris
N, Kwong KK, Harris RE, Purdon P, Kettner N, Hui KKS.
Time-Variant fMRI Activity in the Brainstem and Higher Structures in Response
to Acupuncture. Neuroimage.
2009, 47(1):289-301. |
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2008 |
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Napadow V,
Dhond RP, Conti G, Makris
N, Brown EN, Barbieri R. Brain Correlates of
Autonomic Modulation: Combining Heart Rate Variability with fMRI. Neuroimage.
2008, 42(1):169-77. |
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Dhond RP, Yeh C, Park K, Kettner N, Napadow
V. Acupuncture Modulates Resting State Connectivity in Default and
Sensorimotor Brain Networks. Pain.
2008, 136(3):407-18. |
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Dhond RP, Witzel T, Hamalainen M, Kettner N, Napadow V. Spatiotemporal Mapping the
Neural Correlates of Acupuncture with MEG. J Altern Complement Med. 2008, 14(6):679-88. |
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2007 |
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Napadow V, N Kettner,
J Liu, M Li, KK Kwong, M Vangel,
N Makris, J Audette, Hui KKS. Hypothalamus and Amygdala Response to
Acupuncture Stimuli in Carpal Tunnel Syndrome. Pain. 2007, 130(3):254-66. |
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Napadow V, Liu J, Li M, Kettner N, Ryan A, Kwong KK, Hui KKS, Audette J.
Somatosensory cortical plasticity in carpal tunnel syndrome treated by
acupuncture. Hum Brain Mapp. 2007, Mar;28(3):159-71. |
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Hui KK, Nixon EE, Vangel
MG, Liu J, Marina O, Napadow V,
Hodge SM, Rosen BR, Makris N, Kennedy DN.
Characterization of the "Deqi" Response in Acupuncture. BMC Complement Altern
Med. 2007 Oct 31;7(1):33 |
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2006 |
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Gilbert RJ, Wedeen VJ,
Magnusson LH, Benner T, Wang R, Dai G, Napadow
VJ, Roche KK. Three-dimensional myoarchitecture
of the bovine tongue demonstrated by diffusion spectrum magnetic resonance
imaging with tractography. Anat Rec A Discov Mol Cell Evol Biol. 2006 Nov;288(11):1173-82. |
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Napadow V, Dhond
R, Kennedy D, Hui KKS, Makris
N. Automated Brainstem Co-registration (ABC) for MRI. Neuroimage. 2006, Sep 32(3):1113-9. |
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Gilbert
RJ, Magnusson LH, Napadow V,
Benner T, Wang R, Wedeen V. Mapping complex myoarchitecture in the bovine tongue with diffusion
spectrum magnetic resonance imaging. Biophysical
Journal. 2006, Aug 1; 91(3):1014-22. |
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Napadow V, Kettner N, Ryan A, Kwong KK, Audette J, Hui KKS. Somatosensory Cortical Plasticity in Carpal
Tunnel Syndrome - a Cross-sectional fMRI Evaluation. Neuroimage, 2006, Jun 31(2):520-30. |
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2005 |
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Napadow V, Dhond
RP, Purdon P, Kettner N, Makris
N, Kwong KK, Hui KKS.
Correlating acupuncture fMRI in the human brainstem with heart rate
variability. Conf Proc
IEEE Eng Med Biol Soc.
2005; 5:4496-9. |
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Hui KK, Liu J, Marina O, Napadow V, Haselgrove C, Kwong KK, Kennedy DN, Makris N.
The integrated response of the human cerebro-cerebellar
and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. Neuroimage.
2005 Sep;27(3):479-96. |
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Gilbert
RJ, Napadow VJ. Three-dimensional
muscular architecture of the human tongue determined in vivo with diffusion
tensor magnetic resonance imaging. Dysphagia.
2005 Winter;20(1):1-7. |
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Napadow V, Makris N, Liu J, Kettner NW, Kwong KK, Hui KK. Effects of electroacupuncture
versus manual acupuncture on the human brain as measured by fMRI. Hum Brain Mapp.
2005 Mar;24(3):193-205. |
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2004 |
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Napadow V, Liu J, Kaptchuk TJ. A systematic study of
acupuncture practice: acupoint usage in an outpatient setting in Beijing,
China. Complement Ther
Med. 2004 Dec;12(4):209-16. |
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Napadow V, Kaptchuk TJ. Patient characteristics for
outpatient acupuncture in Beijing, China. J
Altern Complement Med. 2004 Jun;10(3):565-72. |
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2002 |
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Napadow V, Kamm RD, Gilbert
RJ. A biomechanical model of sagittal tongue bending. Journal of Biomechanical Engineering.
2002; 124 (5):547-56. |
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2001 |
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Napadow
V, Mai V, Bankier AA, Gilbert RJ, Edelman R, Chen
Q. Determination
of regional pulmonary parenchymal strain during normal respiration using spin
inversion tagged magnetization MRI. Journal
of Magnetic Resonance Imaging. 2001; 13 (3):467-74. |
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Chen Q, Mai V, Bankier AA, Napadow V, Gilbert RJ, Edelman R. An ultra-fast MR grid tagging
sequence for assessment of local mechanical properties of the lungs. Magnetic Resonance in Medicine. 2001;
45 (1):24-8. |
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Napadow
V, Wedeen VJ, Chen Q, Mai V, So
PTC, Gilbert RJ. Quantitative analysis of 3D-resolved lingual fiber architecture in
intact tissue with diffusion tensor MRI and two-photon microscopy. Biophysical Journal. 2001; 80 (6):2968-75. |
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Wedeen V, Reese TG, Napadow V,
Gilbert RJ. Demonstration of primary and secondary muscle fiber architecture of
the Bovine tongue by diffusion tensor MRI. Biophysical Journal. 2001; 80 (2):1024-8. |
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1999 |
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Napadow V, Chen Q, Wedeen VJ,
Gilbert RJ. Biomechanical basis for lingual muscular deformation during
swallowing. American Journal of
Physiology. 1999; 40 (3):G695-G701. |
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Napadow V, Chen Q, Wedeen VJ,
Gilbert RJ. Intramural mechanics of the human tongue in association
with physiological deformation. Journal
of Biomechanics. 1999; 32 (1):1-12. |
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Grant Support |
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Ongoing
Research Support |
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Brain Plasticity in Carpal Tunnel Syndrome and
its Response to Acupuncture (NIH) R01AT004714 (PI: Napadow) This
study will characterize brain plasticity in Carpal Tunnel Syndrome and will
determine how this central fMRI biomarker is modulated by acupuncture. This
study will also investigate the behavioral consequences of maladaptive
cortical plasticity in this disease population. |
9/15/08 –
5/31/13 |
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Neuroimaging
Acupuncture on Brain Activity in Chronic low Back Pain (NIH) P01AT006663
(PI: Rosen, Project 1 Leader: Napadow) The central goal of this "Center of Excellence for Research
on Complementary and Alternative Medicine" is to apply neuroimaging to
explore the central mechanisms of acupuncture action in chronic low back pain
(cLBP), a clinically significant disorder for which effective modes of
treatment are currently lacking. |
9/01/11 – 6/30/16 |
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An fMRI study
of expectancy on acupuncture treatment outcomes in knee OA (NIH) R01AT005280
(PI: Gollub/Kaptchuk) The goal of this study is to elucidate the functional
neurocircuitry associated with endogenous inhibition of pain perception in
patients with chronic knee pain. |
2/01/10 – 3/31/15 |
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Completed
Research Support |
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Brain Plasticity in Carpal Tunnel Syndrome and
its Response to Acupuncture (NIH) R01AT004714-02S1 (PI:
Napadow)
This competitive
revision supplement will add the testing for cortical adaptation metrics to
the existing Carpal Tunnel Syndrome neuroimaging study. These previously
validated metrics will explore potential S1 disinhibition in CTS patients
using biobehavioral testing. |
9/30/09 –
9/29/11 |
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Neuroimaging Acupuncture
Effects on Human Brain Activity (NIH)
P01AT002048 (PI: Rosen) The central goal of this "Center of Excellence for Research
on Complementary and Alternative Medicine" application is to investigate
the neurobiology of acupuncture in humans and animal models using PET and
fMRI. |
9/26/03 – 5/31/11 |
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Exploring
Neurocircuitry of Acupuncture Action with fMRI (NIH)
K01AT002166 (PI: Napadow) The goals of this study are to understand the neurobiology
involved with the full duration acupuncture treatment, thereby promoting the
development of this ancient healing technique into evidence –based
medicine. |
6/1/04 – 5/30/09 |
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FMRI of Autonomic
Regulation with Acupuncture (NIH)
F05AT003770 (PI: Park) The goals of this study are to decipher the brain correlates for
acupuncture modulation of the autonomic nervous system using multi-modal
techniques combining functional MRI with physiological monitoring. |
9/30/06 - 9/29/09 |
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Clinical Experience
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2005-present |
Acupuncturist, Pain
Management Center, Brigham and Women's Hospital, Chestnut Hill, MA |
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2004-present |
Vitality Acupuncture (private practice) |
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2002-2003 |
Beijing Hospital
of Traditional Chinese Medicine, Wan Jing Hospital, Beijing, China |
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2001-2002 |
NESA Clinic,
Watertown, MA; Aids Care Project, Boston, MA; Dimock
Hospital, Boston, MA 504 hours
supervised clinical internship |
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Education
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2001 |
Doctorate of Philosophy, Division of Health Science and Technology |
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1998 |
Master of Science, Mechanical Engineering |
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1995 |
Bachelor of Science, Mechanical
Engineering |
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2002 |
Master of Acupuncture, Chinese and
Japanese Style Acupuncture |
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Awards |
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2000 |
Finalist, Schnitzer Prize for the Visual Arts |
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