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Vitaly Napadow, Ph.D., Lic.Ac.
Athinoula A. Martinos Center for
Biomedical Imaging Assistant
Professor Department
of Radiology Massachusetts General Hospital Harvard
Medical School 149
Thirteenth Street, Room 2301 Charlestown,
MA 02129 (617) 724-3402 (work) (617) 726-7422 (fax) email: vitaly-at-nmr.mgh.harvard.edu |
{---------Reviews---------Primary Research------}
Research
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- Neuroimaging of the Central Autonomic and Pain
Networks - Neuro-correlates of acupuncture imaged with
fMRI and MEG - Brain mechanisms underlying acupuncture
anti-nausea and analgesic effects |
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Reviews
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2009 |
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Wayne
PM, Hammerschlag R, Langevin HM, Napadow V, Park JJ, Schnyer RN. Resolving paradoxes
in acupuncture research: a roundtable discussion. J Altern Complement Med. 2009
Sep;15(9):1039-44. PMID: 19757981 [pdf
/ abstract] |
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Gray MA, Minati L, Harrison NA, Gianaros PJ, Napadow V,
Critchley HD. Physiological recordings: basic concepts and implementation
during functional Magnetic Resonance Imaging. Neuroimage.
2009; 47(3):1105-15. PMID: 19460445. |
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2008 |
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Napadow V, Ahn A, Longhurst J, Lao
L, Stener-Victorin E, Harris R, Langevin HM. The status and future of
acupuncture mechanism research. J Altern
Complement Med. 2008 Sep;14(7):861-9. PMID: 18803495 |
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2007 |
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Dhond
R, Kettner N, Napadow V. Do the neural correlates of acupuncture and placebo effects
differ? Pain.
2007 Mar 128(1-2):8-12. |
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Dhond
RP, Kettner N, Napadow V. Neuroimaging Acupuncture Effects in the Human Brain. J Altern
Complement Med. 2007, 13(6):603-16. |
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Kong J, Gollub R, Huang
T, Polich G, Napadow
V, Hui K, Vangel M, Rosen B, Kaptchuk TJ. Acupuncture de qi, from qualitative history to quantitative
measurement. J
Altern Complement Med. 2007 Dec;13(10):1059-70. |
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Gilbert
RJ, Napadow
VJ, Gaige TA, Wedeen VJ. Anatomical basis of lingual hydrostatic
deformation. J
Exp Biol. 2007 Dec;210(Pt 23):4069-82. [pdf
/ abstract] |
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2006 |
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Napadow V, Webb M, Pearson N,
Hammerschlag R. Neurobiological Correlates of Acupuncture: November 17-18,
2005. J
Altern Complement Med. 2006 Nov;12(9):931-5. |
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Langevin
HM, Hammerschlag R, Lao L, Napadow V, Schnyer RN, Sherman KJ. Controversies in acupuncture
research: selection of controls and outcome measures in acupuncture clinical
trials. J
Altern Complement Med. 2006 Dec;12(10):943-53. |
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Primary
Research
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2009 |
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Harris RE, Sundgren PC, Craig AD, Kirshenbaum E, Sen A, Napadow V, Clauw DJ. Elevated Insular Glutamate in Fibromyalgia Is Associated With Experimental Pain. Arthritis &
Rheumatism. 2009; 60(10): 3146–3152. PMID: 19790053 |
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Hui KK, Marina O, Claunch
JD, Nixon EE, Fang J, Liu J, Li M, Napadow V, Vangel M, Makris N, Chan ST, Kwong
KK, Rosen BR. Acupuncture mobilizes the brain's default mode and its
anti-correlated network in healthy subjects. Brain Res. 2009; 1287:84-103. PMID:
19559684. |
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Harris RE, Zubieta JK,
Scott DJ, Napadow
V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo
(sham) acupuncture are differentiated by their effects on μ-Opioid Receptors (MORs). Neuroimage. 2009; 47(3): 1077-85.
PMID: 19501658. |
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Napadow V, Dhond RP, Kim J, LaCount L, Vangel M, Harris RE,
Kettner N, Park K. Brain encoding of acupuncture sensation - coupling on-line
rating with fMRI. Neuroimage. 2009; 47(3):1055-65. PMID: 19500677. |
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Napadow V, Dhond RP, Park K, Kim J, Makris N, Kwong KK,
Harris RE, Purdon P, Kettner N, Hui KKS. Time-Variant fMRI Activity in the
Brainstem and Higher Structures in Response to Acupuncture. Neuroimage.
2009, 47(1):289-301. |
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Audette
J, Ryan A, Liu J, Li M, Kettner N, Kwong KK, Hui KKS, Napadow V. 2006. Acupuncture for
Chronic Carpal Tunnel Syndrome: A pilot prospective open-protocol study. Journal of
Alternative and Complementary Medicine. 2009, in review. [pdf
/ abstract] |
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2008 |
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Napadow V, Dhond RP, Conti G, Makris N, Brown EN, Barbieri R.
Brain Correlates of Autonomic Modulation: Combining Heart Rate Variability
with fMRI. Neuroimage.
2008, 42(1):169-77. |
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Dhond RP, Yeh C, Park K,
Kettner N, Napadow
V. Acupuncture Modulates Resting State Connectivity in Default and
Sensorimotor Brain Networks. Pain. 2008, 136(3):407-18. |
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Dhond
RP, Witzel T, Hamalainen M, Kettner N, Napadow V. Spatiotemporal Mapping the Neural
Correlates of Acupuncture with MEG. J Altern Complement Med. 2008, 14(6):679-88. |
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2007 |
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Napadow V, N Kettner, J Liu, M Li,
KK Kwong, M Vangel, N Makris, J Audette, Hui KKS. Hypothalamus and Amygdala
Response to Acupuncture Stimuli in Carpal Tunnel Syndrome. Pain. 2007,
130(3):254-66. |
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Napadow V, Liu J, Li M, Kettner N,
Ryan A, Kwong KK, Hui KKS, Audette J. Somatosensory cortical plasticity in
carpal tunnel syndrome treated by acupuncture. Hum Brain Mapp. 2007,
Mar;28(3):159-71. |
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Hui
KK, Nixon EE, Vangel MG, Liu J, Marina O, Napadow V, Hodge SM, Rosen BR, Makris
N, Kennedy DN. Characterization of the "Deqi" Response in
Acupuncture. BMC
Complement Altern Med. 2007 Oct 31;7(1):33 |
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2006 |
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Gilbert RJ, Wedeen VJ, Magnusson LH, Benner T,
Wang R, Dai G, Napadow VJ, Roche KK. Three-dimensional myoarchitecture of the
bovine tongue demonstrated by diffusion spectrum magnetic resonance imaging
with tractography. Anat Rec A Discov Mol Cell Evol Biol. 2006 Nov;288(11):1173-82. |
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Napadow V, Dhond R, Kennedy D, Hui
KKS, Makris N. Automated Brainstem Co-registration (ABC) for MRI. Neuroimage.
2006, Sep 32(3):1113-9. |
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Gilbert
RJ, Magnusson LH, Napadow V, Benner T, Wang R, Wedeen V. Mapping complex
myoarchitecture in the bovine tongue with diffusion spectrum magnetic
resonance imaging. Biophysical Journal. 2006, Aug 1; 91(3):1014-22. |
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Napadow V, Kettner N, Ryan A, Kwong KK, Audette J, Hui KKS.
Somatosensory Cortical Plasticity in Carpal Tunnel Syndrome - a Cross-sectional
fMRI Evaluation. Neuroimage, 2006, Jun 31(2):520-30. |
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2005 |
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Napadow V, Dhond RP, Purdon P,
Kettner N, Makris N, Kwong KK, Hui KKS. Correlating acupuncture fMRI in the
human brainstem with heart rate variability. Conf Proc IEEE Eng Med Biol Soc.
2005; 5:4496-9. |
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Hui
KK, Liu J, Marina O, Napadow V, Haselgrove C, Kwong KK, Kennedy DN, Makris N. The integrated
response of the human cerebro-cerebellar and limbic systems to acupuncture
stimulation at ST 36 as evidenced by fMRI. Neuroimage. 2005 Sep;27(3):479-96. |
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Gilbert
RJ, Napadow
VJ. Three-dimensional muscular architecture of the human tongue
determined in vivo with diffusion tensor magnetic resonance imaging. Dysphagia.
2005 Winter;20(1):1-7. |
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Napadow V, Makris
N, Liu J, Kettner NW, Kwong KK, Hui KK. Effects of electroacupuncture versus
manual acupuncture on the human brain as measured by fMRI. Hum Brain Mapp.
2005 Mar;24(3):193-205. |
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2004 |
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Napadow V, Liu J,
Kaptchuk TJ. A systematic study of acupuncture practice: acupoint usage in an
outpatient setting in Beijing, China. Complement Ther Med. 2004 Dec;12(4):209-16. |
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Napadow V,
Kaptchuk TJ. Patient characteristics for outpatient acupuncture in Beijing,
China. J
Altern Complement Med. 2004 Jun;10(3):565-72. |
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2002 |
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Napadow V, Kamm RD, Gilbert RJ. A biomechanical model of sagittal tongue
bending. Journal
of Biomechanical Engineering. 2002; 124 (5):547-56. |
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2001 |
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Napadow V, Mai V, Bankier AA,
Gilbert RJ, Edelman R, Chen Q. Determination of regional pulmonary parenchymal
strain during normal respiration using spin inversion tagged magnetization
MRI. Journal
of Magnetic Resonance Imaging. 2001; 13 (3):467-74. |
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Chen Q, Mai V, Bankier AA, Napadow V, Gilbert RJ, Edelman
R. An ultra-fast
MR grid tagging sequence for assessment of local mechanical properties of the
lungs. Magnetic
Resonance in Medicine. 2001; 45 (1):24-8. |
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Napadow V, Wedeen VJ, Chen Q,
Mai V, So PTC, Gilbert RJ. Quantitative analysis of 3D-resolved lingual
fiber architecture in intact tissue with diffusion tensor MRI and two-photon
microscopy. Biophysical Journal. 2001; 80 (6):2968-75. |
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Wedeen V, Reese TG, Napadow V, Gilbert RJ. Demonstration of primary
and secondary muscle fiber architecture of the Bovine tongue by diffusion
tensor MRI. Biophysical Journal. 2001; 80 (2):1024-8. |
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1999 |
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Napadow V, Chen
Q, Wedeen VJ, Gilbert RJ. Biomechanical basis for lingual muscular
deformation during swallowing. American Journal of Physiology. 1999; 40
(3):G695-G701. |
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Napadow V, Chen
Q, Wedeen VJ, Gilbert RJ. Intramural mechanics of the human tongue in
association with physiological deformation. Journal of Biomechanics. 1999;
32 (1):1-12. |
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Grant Support |
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Exploring
Neurocircuitry of Acupuncture Action with fMRI (NIH)
K01AT002166 (PI: Napadow)
The goals of this study are to understand the neurobiology involved
with the full duration acupuncture treatment, thereby promoting the
development of this ancient healing technique into evidence –based
medicine. |
12/1/04 - 11/30/09 |
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FMRI
of Autonomic Regulation with Acupuncture (NIH)
F05AT003770 (PI: Park) The goals of this study are to decipher the brain correlates for
acupuncture modulation of the autonomic nervous system using multi-modal
techniques combining functional MRI with physiological monitoring. |
9/30/06 - 9/29/09 |
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Brain Plasticity in
Carpal Tunnel Syndrome and its Response to Acupuncture (NIH) R01AT004714 (PI: Napadow) This
study will characterize brain plasticity in Carpal Tunnel Syndrome and will
determine how this central fMRI biomarker is modulated by acupuncture. This
study will also investigate the behavioral consequences of maladaptive
cortical plasticity in this disease population. |
9/15/08 –
5/31/13 |
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Neuroimaging
Acupuncture Effects on Human Brain Activity (NIH)
P01AT002048 (PI: Rosen) The central goal of this "Center of Excellence for Research
on Complementary and Alternative Medicine" application is to investigate
the neurobiology of acupuncture in humans and animal models using PET and
fMRI. |
9/26/03 – 5/31/11 |
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Clinical Experience
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2005-present |
Acupuncturist, Pain
Management Center, Brigham and Women's Hospital, Chestnut Hill, MA |
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2004-present |
Vitality Acupuncture (private practice) |
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2002-2003 |
Beijing Hospital
of Traditional Chinese Medicine, Wan Jing Hospital, Beijing, China |
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2001-2002 |
NESA Clinic,
Watertown, MA; Aids Care Project, Boston, MA; Dimock Hospital, Boston, MA 504 hours
supervised clinical internship |
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Education
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2001 |
Doctorate of Philosophy, Division of Health Science and Technology |
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1998 |
Master of Science, Mechanical Engineering |
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1995 |
Bachelor of Science, Mechanical Engineering |
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2002 |
Master of Acupuncture, Chinese and Japanese Style Acupuncture |
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Awards |
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2000 |
Finalist,
Schnitzer Prize for the Visual Arts |
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