Lee Josephson, PhD

Professional Information


Associate Professor, Harvard Medical School
Associate Chemist, Massachusetts General Hospital


Ph.D. Biochemistry, State University of New York at Stony Brook, 1975
BS , University of Wisconsin,
PhD Medicine/Chemistry, State University of NY, Stoney Brook,

Affiliated Faculty


Mailing Address

Building 149
13th Street
Charlestown, MA 02129 USA

General Contact Information



I obtained my B.S. in chemistry (U. of Wisconsin, Madison),
Ph.D. in biochemistry (State University of NY at Stony Brook), and did a
Post-doctoral fellowship in the laboratory of Guido Guidotti (Harvard
University), where I collaborated with Lew Cantley in discovering the
biological actions of vanadate.  
I was a co-founder of AMAG Pharmaceuticals and then served as its
Vice-President and Chief Scientific Officer (1982-1997), developing magnetic
nanoparticles for applications in biology and medicine.  I joined the Ralph Weissleder at the Center
for Molecular Imaging Research in 1998. Currently, I am a member of the
Martinos Center for Biomedical Imaging, a member of the Center for
Translational Nuclear Medicine and Molecular Imagining (Department of Nuclear
Medicine) at MGH, and an Associate Professor at Harvard Medical School.  My research interests include (i)
self-activating viridin prodrugs, (ii) the use of magnetic particles for MR
based sensors, (iii) the design and synthesis of radioactive, magnetic and
fluorescent imaging probes, for PET, MRI, or fluorescence imaging and, (iv) the
design of multimodal probes for visualizing cell death. I am a co-founder and a
consultant for T2 Biosystems, a company developing MR based assays and sensors.