Ventricular Remodeling

The clinical trials group plays a central role in the mission of the Program in Cardiovascular Magnetic Resonance. The aims of the group are to promote the role of cardiac MRI in clinical trials in general and, more specifically, to translate novel techniques developed in our group into the clinical setting. We have recently installed a 32-channel Siemens Avanto (1.5 Tesla) scanner in our center, which provides the platform for many of our clinical trials. In addition, the Siemens Trio (3 Tesla) system in our center is available to us for cardiovascular research studies.  Active trials are currently being conducted in several areas relevant to ventricular remodeling. These include the use of prolonged anti-coagulation in the acute infarct setting to limit post-infarction remodeling, and the use of growth hormone therapy to promote reverse remodeling in chronic heart failure. Trials are conducted in collaboration with several clinical divisions at the Massachusetts General Hospital and include NIH-sponsored trials as well as others sponsored by industry.