Publications
Buckner RL, Sepulcre J, Talukdar T, Krienen FM, Liu H, Hedden T, Andrews-Hanna JR, Sperling RA, Johnson KA. Cortical hubs revealed by intrinsic functional connectivity: Mapping, assessment of stability, and relation to Alzheimer's disease. Journal of Neuroscience 2009; 29(6):1860-73. PMCID: PMC2750039
Sperling RA, LaViolette PS, O’Keefe K, O’Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DS, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron 2009; 63:178-88. PMCID: PMC2738994
Hedden T, Van Dijk KR, Becker JA, Mehta A, Sperling RA, Johnson KA, Buckner RL. Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. Journal of Neuroscience 2009; 29(40):12686-94. PMCID: PMC2808119
Rentz DM, Locascio JJ, Becker JA, Moran EK, Eng E, Buckner RL, Sperling RA, Johnson KA. Cognition, reserve and amyloid deposition in normal aging. Annals of Neurology 2010;67(3):353-64. PMCID: PMC3074985
Wang L, LaViolette P, O'Keefe K, Putcha D, Bakkour A, Van Dijk KR, Pihlajamäki M, Dickerson B, Sperling R. Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. Neuroimage 2010; 51(2):910-7. Epub 2010 Feb 24. PMCID: PMC2856812
Sperling RA, Dickerson BC, Philajamaki M, Vannini P, LaViolette P, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. NeuroMolecular Medicine 2010 Mar; 12(1):27-43. PMCID: PMC3036844
Wang L, Negreira A, LaViolette P, Bakkour A, Sperling RA, Dickerson BC. Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability. Hippocampus 2010 Mar;20(3):345-51. PMCID: PMC2872925
Vannini P, O’Brien J, O’Keefe K, Pihlajamaki MM, LaViolette P, Sperling RA. What goes down must come up: Role of the posteromedial cortices in encoding and retrieval. Cerebral Cortex 2011 Jan; 21(1):22-34. PMCID: PMC3000562
Putcha D, O'Keefe K, LaViolette P, O'Brien J, Greve D, Rentz DM, Locascio J, Atri A, Sperling R. Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults. Hum Brain Mapp 2011 Dec;32(12):2027-44. doi: 10.1002/hbm.21166. Epub 2011 Jan 21. PMCID: PMC3551453.
Pihlajamäki M, O'Keefe K, O'Brien J, Blacker D, Sperling RA. Failure of repetition suppression and memory encoding in aging and Alzheimer's disease. Brain Imaging Behav 2011 Mar;5(1):36-44. PMCID: PMC3034137
Dickerson B, Stoub R, Shah R, Sperling R, Killiany RJ, Albert MS, Hyman BT, Blacker D, deToledo-Morell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology 2011 Apr 19;76(16):1395-402. PMCID: PMC3087406
Atri A, O'Brien JL, Sreenivasan A, Rastegar S, Salisbury S, DeLuca AN, O'Keefe KM, LaViolette PS, Rentz DM, Locascio JJ, Sperling RA. Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials. Arch Neurol 2011 May;68(5):599-606. PMCID: PMC3291175
Drzezga A, Becker JA, Van Dijk KRA, Sreenivasan A, Talukdar T, Sullivan C, Schultz AP, Sepulcre J, Putcha D, Greve D, Johnson KA, Sperling RA. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid-burden. Brain 2011 Jun; 134(6):1635-46. Epub 2011 Apr 13. PMCID: PMC3102239
Becker JA, Hedden T, Carmasin J, Maye J, Rentz DM, Putcha D, Fischl B, Greve D, Marshall GA, Salloway S, Marks D, Buckner RL, Sperling RA and Johnson KA. Amyloid-β associated cortical thinning in clinically normal elderly. Ann Neurol 2011 Jun;69(6):1032-42. PMCID: PMC3117980
Freir DB, Fedriana R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aß oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiol Aging 2011;32:2211-2218. PMCID: PMC2891223
Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, Thies B, Phelps CH. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011 May;7(3):257-62. PMCID: PMC3096735
Jin M, Shepardson N, Yang T, Walsh D, Selkoe DJ. Soluble amyloid ß-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci USA 2011; Apr 5;108(14):5819-24. PMCID: PMC3078381
Li S, Jin M, Koeglsperger T, Shepardson N, Shankar G, Selkoe D. Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci 2011 May 4; 31(18):6627-38. PMCID: PMC3100898
Rentz DM, Amariglio RE, Becker JA, Frey M, Olson LE, Frishe K, Carmasin J, Maye JE, Johnson KA, Sperling RA. Face-name associative memory performance is related to amyloid burden in normal elderly. Neuropsychologia 2011 Jul;49(9):2776-83. PMCID: PMC3137730
Marshall GA, Olson LE, Frey MT, Maye J, Becker JA, Rentz DM, Sperling RA, Johnson KA, Alzheimer's Disease Neuroimaging Initiative. Instrumental activities of daily living impairment is associated with increased amyloid burden. Dementia and Geriatric Cognitive Disorders 2011;31(6):443-50. Epub 2011 Jul 20. PMCID: PMC3150869
Yang W, Lui RL, Gao JH, Chan TF, Yau ST, Sperling RA, Huang X. Independent Component Analysis-Based Classification of Alzheimer's Disease MRI Data. Journal of Alzheimer’s Disease 2011;24(4):775-83. PMID: 21321398
Dzrezga A, Becker JA, Sreenivasan A, Talukdar T, Van Dijk K, Sullivan C, Schultz AP, Sepulcre J, Buckner RL, Johnson KA, Sperling RA. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid-burden. Brain 2011 June; 134(6):1635-1646. PMCID: PMC3102239
Amariglio RE, Townsend MK, Grodstein F, Sperling RA, Rentz DM. Specific subjective memory complaints in older persons may indicate poor cognitive function. J Am Geriatr Soc 2011 Sep 15;59(9):1612-7. PMCID: PMC3315361
Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement 2011 Jul;7(4):386-395.e6. Erratum in: Alzheimers Dement. 2011 Sep;7(5):556. PMCID: PMC3710290
Putcha D, Brickhouse M, O'Keefe K, Sullivan C, Rentz D, Marshall G, Dickerson B, Sperling R. Hippocampal hyperactivation associated with cortical thinning in Alzheimer’s disease signature regions in non-demented elderly adults. J Neurosci 2011 Nov 30;31(48):17680-8. PMCID: PMC3289551
Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny D, Cavanaugh W, Yang T, Holtzman D, Cirrito J, Selkoe DJ. Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF vs. parenchymal Aβ during age-related plaque formation. J Neurosci 2011 Nov;31(44):15861-9. PMCID: PMC3227224
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011 May;7(3):280-92. PMCID: PMC3220946
Townsend MK, Okereke OI, Xia W, Yang T, Selkoe DJ, Grodstein F. Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study. Alzheimer Dis Assoc Disord 2012 Jan;26(1):50-4. PMCID: PMC3140548
Vannini P, Hedden T, Sullivan C, Sperling RA. Differential functional response in the posteromedial cortices and hippocampus to stimulus repetition during successful memory encoding. Hum Brain Mapp 2012 Feb 17. PMCID: PMC3432294
Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, Morris JC, Nordberg A, Petersen RC, Reiman EM, Selkoe DJ, Sperling RA, Van Laere K, Weiner MW, Drzezga A. Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. Eur J Nucl Med Mol Imaging 2012 Feb;39(2):209-19. PMCID: PMC3261395
Sabuncu MR, Buckner RL, Smoller JW, Lee PH, Fischl B, Sperling, RA for the Alzheimer's Disease Neuroimaging Initiative. The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects. Cereb Cortex 2012;22:2653-2661. PMCID: PMC3464416
Sepulcre J, Sabuncu MR, Yeo TB, Liu H, Johnson KA. Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain. J Neurosci 2012;32:10649-10661. PMCID: PMC3483645
Hedden T, Van Dijk KRA, Shire E., Sperling RA, Johnson KA, Buckner RL. Failure to modulate attentional control in advanced aging linked to white matter pathology. J Neurosci 2012 May; 32:16233-16242. PMCID: PMC3328340
Vannini P, Hedden T, Huijbers W, Ward A, Johnson KA, Sperling RA. The Ups and Downs of the Posteromedial Cortex: Age- and Amyloid-Related Functional Alterations of the Encoding/Retrieval Flip in Cognitively Normal Older Adults. Cereb Cortex 2012 May 14. PMCID: PMC3643714
Desikan RS, McEvoy LK, Thompson WK, Holland D, Brewer JB, Aisen PS, Sperling RA, Dale AM; for the Alzheimer's Disease Neuroimaging Initiative. Amyloid-β-Associated Clinical Decline Occurs Only in the Presence of Elevated P-tau. Archives of Neurology 2012 Jun; 69(6):709-13. PMCID: PMC3423526
Gomperts SN, Locascio JJ, Marquie M, Santarlasci AL, Rentz DM, Maye J, Johnson KA, Growdon JH. Brain amyloid and cognition in Lewy body diseases. Mov Disord 2012 Jul;27(8):965-73. PMCID: PMC3725259
Doraiswamy PM, Sperling RA, Coleman RE, Johnson KA, Reiman EM, Davis MD, Grundman M, Sabbagh MN, Sadowsky CH, Fleisher AS, Carpenter A, Clark CM, Joshi AD, Mintun MA, Skovronsky DM, Pontecorvo MJ; AV45-A11 Study Group. Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study. Neurology 2012 Oct 16;79(16):1636-44. doi: 10.1212/WNL.0b013e3182661f74. PMCID: PMC3468774
Vannini P, Hedden T, Becker JA, Sullivan C, Deepti Putcha, Rentz D, Johnson KA, Sperling RA. Age and amyloid-related alterations in default network habituation to stimulus repetition. Neurobiol Aging 2012 Jul;33(7):1237-52. PMCID: PMC3111876
Chhatwal JP, Sperling RA. Functional MRI of mnemonic networks across the spectrum of normal aging, mild cognitive impairment, and Alzheimer's disease. J Alzheimers Dis 2012;31 Suppl 3:S155-67. Review. PMCID: PMC3736339
Amariglio RE, Frishe K, Olson LE, Wadsworth LP, Lorius N, Sperling RA, Rentz DM. Validation of the Face Name Associative Memory Exam in cognitively normal older individuals. J Clin Exp Neuropsychol 2012;34(6):580-7. PMCID: PMC3391747
Huijbers W, Vannini P, Sperling RA, C M P, Cabeza R, Daselaar SM. Explaining the encoding/retrieval flip: memory-related deactivations and activations in the posteromedial cortex. Neuropsychologia 2012 Dec; 50(14):3764-74. PMCID: PMC3811140
Amariglio RE, Becker JA, Carmasin J, Wadsworth LP, Lorius N, Sullivan C, Maye JE, Gidicsin C, Pepin LC, Sperling RA, Johnson KA, Rentz DM. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia 2012 Oct;50(12):2880-6. PMCID: PMC3473106
Hedden T, Mormino EC, Amariglio RE, et al. Cognitive Profile of Amyloid Burden and White Matter Hyperintensities in Cognitively Normal Older Adults. J Neurosci 2012 Nov;14;32(46):16233-42. PMCID: PMC3523110
Gurol ME, Viswanathan A, Gidicsin C, Hedden T, Martinez-Ramirez S, Dumas A, Vashkevich A, Ayres AM, Auriel E, van Etten E, Becker A, Carmasin J, Schwab K, Rosand J, Johnson KA, Greenberg, SM. (2013) Cerebral amyloid angiopathy burden associated with leukoaraiosis: A positron emission tomography/magnetic resonance imaging study. Ann Neurol 2012 Dec 13. PMCID: PMC3715595
Johnson KA, Sperling RA, Gidicsin CM, Carmasin JS, Maye JE, Coleman RE, Reiman EM, Sabbagh MN, Sadowsky CH, Fleisher AS, Murali Doraiswamy P, Carpenter AP, Clark CM, Joshi AD, Lu M, Grundman M, Mintun MA, Pontecorvo MJ, Skovronsky DM; AV45-A11 study group. Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging. Alzheimers Dement 2013 Jan 30. PMCID: PMC3800236
Fleisher AS, Chen K, Liu X, Ayutyanont N, Roontiva A, Thiyyagura P, Protas H, Joshi AD, Sabbagh M, Sadowsky CH, Sperling RA, Clark CM, Mintun MA, Pontecorvo MJ, Coleman RE, Doraiswamy PM, Johnson KA, Carpenter AP, Skovronsky DM, Reiman EM. Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease. Neurobiol Aging 2013 Jan;34(1):1-12. doi: 10.1016/j.neurobiolaging.2012.04.017. Epub 2012 May 24. PubMed PMID: 22633529.
Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Carrillo MC, Hartley DM, Hedrick S, Pappas V, Thies WH; Alzheimer's Association; Society of Nuclear Medicine and Molecular Imaging; Amyloid Imaging Taskforce. Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association. Alzheimers Dement 2013 Jan;9(1):e-1-16. PMCID: PMC3733252
Gomperts SN, Locascio JJ, Rentz D, Santarlasci A, Marquie M, Johnson KA, Growdon JH. Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia. Neurology 2013 Jan 1;80(1):85-91. Epub 2012 Dec 12. PMCID: PMC3589197
Ward AM, Schultz AP, Huijbers W, Van Dijk KR, Hedden T, Sperling RA. The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system. Hum Brain Mapp 2013 Feb 13. PMCID: PMC3773261
Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ. Environmental Novelty potently prevents impairment of hippocampal synaptic plasticity by human Aβ oligomers via a β2-adrenergic signaling pathway. Neuron 2013 Mar 6;77(5):929-41. PMCID: PMC3596823
Sperling RA, Johnson KA, Doraiswamy PM, Reiman EM, Fleisher AS, Sabbagh MN, Sadowsky CH, Carpenter A, Davis MD, Lu M, Flitter M, Joshi AD, Clark CM, Grundman M, Mintun MA, Skovronsky DM, Pontecorvo MJ; AV45-A05 Study Group. Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiol Aging 2013 Mar;34(3):822-31. PMCID: PMC3518678
Yang T, Hong S, O’Malley T, Farrell MA, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid ß-protein reveal natural Aß oligomers in human brain but not CSF. Alzheimer’s and Dementia 2013 Mar;9(2):99-112. PMCID: PMC3604133
Desikan RS, McEvoy LK, Holland D, Thompson WK, Brewer JB, Aisen PS, Andreassen OA, Hyman BT, Sperling RA, Dale AM. APOE ε4 does not modulate amyloid-β associated neurodegeneration in preclinical Alzheimer’s disease. American Journal of Neuroradiology 2013 Mar; 34(3):505-10. Epub 2012 Sep 13. PMID: 22976236 NIHMSID: 576913
Gomperts SN, Johnson KA, Growdon J. Reply: Beyond the limits of detection: failure of PiB imaging to capture true Aβ burden. Mov Disord 2013 Mar;28(3):407. PMCID: PMC3741662
Bradshaw EM, Chibnik LB, Keenan BT, Ottoboni L, Raj T, Tang A, Rosenkrantz LL, Imboywa S, Lee M, Von Korff A; Alzheimer Disease Neuroimaging Initiative, Morris MC, Evans DA, Johnson K, Sperling RA, Schneider JA, Bennett DA, De Jager PL. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat Neurosci 2013 Jul;16(7):848-50. PMCID: PMC3703870
Hedden T, Oh H, Younger AP, Patel TA. Meta-analysis of amyloid-cognition relations in cognitively normal older adults. Neurology 2013;80:1341-1348. PMCID: PMC3656457
Sepulcre J, Sabuncu MR, Becker JA, Sperling RA, Johnson KA. In Vivo Characterization of the Early States of the Beta-Amyloid Network. Brain 2013 Jul;136(Pt 7):2239-52. PMCID: PMC3692037
Huijbers W, Schultz AP, Vannini P, McLaren DG, Wigman SE, Ward AM, Hedden T, Sperling RA. The Encoding/Retrieval Flip: Interactions between Memory Performance and Memory Stage and Relationship to Intrinsic Cortical Networks. J Cogn Neurosci 2013 Jul;25(7):1163-79. PMCID: PMC3730829
Perez-Nievas BG, Stein TD, Tai HC, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M, Serrano-Pozo A, Frosch MP, Lowe V, Parisi JE, Petersen RC, Ikonomovic MD, López OL, Klunk W, Hyman BT, Gómez-Isla T. Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain 2013 Aug;136(Pt 8):2510-26. PMCID: PMC3722351
Ward AM, McLaren DG, Schultz AP, Chhatwal J, Boot BP, Hedden T, Sperling RA. Daytime Sleepiness is Associated with Decreased Default Mode Network Connectivity in Both Young and Cognitively Intact Elderly Subjects. Sleep 2013 Nov;36(11):1609-15. PMCID: PMC3792376
Marshall GA, Donovan NJ, Lorius N, Gidicsin CM, Maye J, Pepin LC, Becker JA, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. Apathy is associated with increased amyloid burden in mild cognitive impairment. J Neuropsychiatry Clin Neurosci 2013 Fall;25(4):302-7. PMID: 24247857. NIHMS ID: 561944
Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gómez-Isla T, Betensky RA, Growdon JH, Johnson K, Frosch MP, Sperling RA, Hyman BT. Mild to Moderate Alzheimer Dementia with Insufficient Neuropathological Changes. Ann Neurol 2014 Mar 1. doi: 10.1002/ana.24125. [Epub ahead of print] PMID: 24585367
Huijbers W, Mormino E, Wigman S, Ward A, Vannini P, McLaren D, Becker J, Schultz A, Hedden T, Johnson K, and Sperling R. Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults. Journal of Neuroscience 2014. In Press.
Papp, KV, Amariglio, RE, Sperling, RA, Rentz, DM. Development of a shortened Face Name Memory Exam for use in Older Adults, The Clinical Neuropsychologist 2014. In Press.
Mormino EC, Betensky RA, Hedden T, Schultz AP, Ward A, Huijbers W, Rentz DM, Johnson KA, Sperling RA; for the Alzheimer's Disease Neuroimaging Initiative; for the Australian Imaging Biomarkers and Lifestyle flagship study of ageing; and for the Harvard Aging Brain Study. Amyloid and APOE4 interact to influence short-term decline in preclinical Alzheimer’s disease. Neurology 2014. In Press.