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  • Spring 2017: Congratulations to Megan Quimby, Claire Cordella, Katie Brandt, Joyce Shapiro Gordon, Deepti Putcha, and other members of our team on recent presentations at national meetings.
  • Winter 2016-2017: Congratulations to Dr. Chenjie Xia and our team on the publication of a new tau PET study in typical and atypical AD patients in JAMA Neurology. Congratulations to Dr. Jessica Collins for leading our team in a collaboration with investigators at UCSF on a new study of atrophy in relation to large-scale functional-anatomic brain networks in patients with semantic variant PPA.
  • Fall 2016: We are delighted that our recent research on SuperAging received international attention from colleagues and news media. We hope this work will lead toward new ideas about how to maintain our brain and age successfully. Read more about it here.
  • Dr. Dickerson's book on FTD was published by Cambridge University Press; it's available from Amazon.
  • My colleague and friend Dr. Ali Atri and I edited Dementia: Comprehensive Principles and Practice, (Oxford, 2014); to order, visit, search for Dickerson and enter the following promotion code to receive a 30% discount: 32863. Also order on Amazon here.
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  • Welcome to the Dickerson Lab

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    In Brad Dickerson's Laboratory, we seek to understand the relationships between brain anatomy, physiology, and behavior in humans across the lifespan and in those with neurodegenerative diseases. Major focus areas of our research include: memory abilities and the brain systems that subserve them in normal individuals and how these abilities and brain systems change with aging, Alzheimer's disease, and related disorders (including frontotemporal dementias and posterior cortical atrophy); understanding how aging, Alzheimer's disease, and related disorders alter the normal anatomy and function of the human brain, and determining whether this knowledge can assist in diagnosis and monitoring of these conditions; and the further development of new neuroimaging and behavioral technology for making quantitative measurements of these abilities and brain systems. We are also pursuing studies of language and semantic knowledge in progressive aphasias; and social cognition and affective processing in normal aging and how these are affected by frontotemporal dementias and Alzheimer's disease. In addition, we pursue some investigations related to the development and promotion of capacities to compensate for age- and disease-related changes.

    In our research on the anatomy and physiology of memory, we study brain structure and function using magnetic resonance imaging (structural and functional MRI) and positron emission tomography (PET), and try to understand the roles of various brain regions in normal human memory. Behavioral studies are also in progress to better understand how normal human memory works. Studies of aging focus primarily on individuals in their 50-90s, and seek to identify age-related changes in brain structure and function that relate to memory, language, and cognitive/affective/social task performance. Such investigations are also ongoing in people with mild cognitive impairment, Alzheimer's disease, primary progressive aphasia, frontotemporal dementia, posterior cortical atrophy, progressive supranuclear palsy, corticobasal degeneration, and related disorders.

    In our research on the ways that aging, Alzheimer's disease, and related disorders affect brain anatomy, we use MRI and PET to investigate the locations and degrees to which brain regions are affected by the disease, the molecules involved in these diseases, and how these imaging measures relate to clinical symptoms and difficulties with the performance of cognitive tasks.

    We continue to develop and apply neuroimaging methods including "ultra" high resolution MRI to study brain structure and function at an unprecedented level of detail. We are actively working with colleagues to develop and apply new PET methods to measure molecules in the brain that have never been measured before, such as tau. We are currently working to refine imaging methods to measure the functional and structural integrity of memory and other systems of the brain, including the functional connectivity of brain systems and how these measures relate to behavior.

    A special focus of our research is on mild cognitive impairment (MCI), in which individuals demonstrate subtle memory loss that may be the earliest symptom of Alzheimer's disease but which is often difficult to distinguish from the aging process itself. We believe that brain imaging tools offer the potential to assist in the identification of individuals with the earliest symptoms of Alzheimer's disease, for whom treatments currently under evaluation to slow the disease process may ultimately be effective. Other individuals may have different types of mild cognitive impairment with early language, executive, or affective difficulties, which may be related to Alzheimer or non-Alzheimer pathologies.

    In conjunction with a number of collaborators, in 2007 and 2008 Dr. Dickerson founded the MGH Frontotemporal Dementia Unit, Primary Progressive Aphasia Program, and Posterior Cortical Atrophy Program. The MGH FTD Unit aims to develop better knowledge about and diagnosis and treatment of all forms of FTD and related focal dementia syndromes. The PPA Program aims to better understand and treat primary progressive aphasia syndromes using existing technologies (including speech therapy) and by developing new diagnostic and treatment technologies. The PCA Program aims to better differentiate focal syndromes involving parietal and parieto-occipital dysfunction from other disorders for early diagnosis, and to better understand these disorders with the ultimate goal of improving treatment options.

    Further details on projects in all of these areas are presented in the "Research" pages. "People" contains information on members of our research team. The "Tools" pages describe the tools and technology we use, some of which are uniquely available through the Martinos Center for Biomedical Imaging, the MGH Gerontology Research Unit, the Massachusetts Alzheimer's Disease Research Center, the Nuclear Medicine and Molecular Imaging program, and the MGH Center for Morphometric Analysis, with which our lab is affiliated. Scientific and clinical manuscripts are listed in "Publications." "How to participate" describes opportunities for participants of all types, including research subjects (we are currently recruiting), collaborators/students, and donors. The "MCI wiki" is an internal resource of our group's collective knowledge.

    Our research is generously funded by the National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institute of Mental Health, and the Alzheimer's Association, as well as generous private donors.

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    Recent Events
    Dr. Dickerson and team presented new data and ideas at the 2017 Alzheimer's Association International Conference in London in July 2017.

    The 21st Harvard Dementia Course ran from June 7 - June 10, 2017 in Boston. Click here to access supplemental program information.

    The 21st Charles River Association for Memory meeting
    Drs. Eichenbaum, Dickerson, Schacter, and Gabrieli were delighted to host the 21st meeting of the Charles River Association for Memory, featuring talks by memory experts from around the world. See the CRAM website for more details.

    2017 American Academy of Neurology meeting
    Dr. Dickerson directed the Neurology of Social Behavior course and taught in the annual half-day Primer of Behavioral Neurology course. Dr. Dickerson and his team also presented their latest research.

    Dr. Dickerson chaired the MA/NH Alzheimer's Association Spring Research Forum, an event celebrating the Alzheimer’s Association’s support of research. We were excited to present a panel discussion of a review of research and current cutting edge thinking to over 300 attendees. The panel participants included Drs. Dennis Selkoe, Rudy Tanzi, and Andrew Budson. Click here to watch a video recording of the program.