Brainmap Seminar: PET imaging of the cannabinoid CB1 receptor with [11C]OMAR

PET imaging of the cannabinoid CB1 receptor with [11C]OMAR

Marc Normandin, Ph.D. (MGH)

The central cannabinoid system has essentials roles in regulating the signaling of other neurotransmitters and has emerged as a target of interest in psychiatric research and drug development. Several radioligands have recently been developed for imaging the cannabinoid CB1 receptor using PET. In this presentation, we will describe the characterization of one such tracer, [11C]OMAR, beginning with preclinical validation in non human primates and subsequent translation to evaluation in healthy humans. Results from [11C]OMAR imaging in clinical research studies will be shown. Image quantification methods will be compared and the importance of using an appropriately validated analysis technique will be demonstrated. Recommendations and directions for future work in PET imaging of the cannabinoid system will be discussed.