Chem Commun (Camb). 2013 Sep 21;49(73):8060-2 doi: 10.1039/c3cc44116d. 2013 Aug 02.

[Gd(CyPic3A)(H2O)2](-): a stable, bis(aquated) and high-relaxivity Gd(iii) complex

Gale EM, Kenton N, Caravan P.


We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(iii) complexes of hydration state q = 2. [Gd(CyPic3A)(H2O)2](-) affords an r1 value of 5.70 mM(-1) s(-1) at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.

PMID: 23903523