Abstract

To determine the serial changes in T1 and T2 relaxation times of myocardial infarction, and their relationship to observed changes in water content, regional myocardial blood flow, and histopathology, rabbits were studied at 14 time intervals ranging from 30 min to 6 months after coronary artery ligation. All values were compared to a control group. Hearts were subdivided into infarct and normal segments for measurement of blood flow, water content, and relaxation times (20-MHz spectrometer); other hearts were excised intact for histopathologic studies. T1 relaxation time of infarcted myocardium did not change significantly compared to control over the 6-month study period. T2 relaxation time increased (P less than 0.0001) at 3 days and returned to baseline by 2 months. Consonant with the increase in T2 of infarct, nuclear magnetic resonance (NMR) images at 3 days demonstrated an increase in signal intensity of infarct compared to surrounding normal myocardium. At 6 months, marked myocardial thinning was observed without changes in signal intensity. Changes in T2 of infarcted myocardium were not related to changes in water content or severity of ischemia, but correlated best with infarct healing and scar formation as detected on histopathology. In conclusion, the findings of this study indicate that T2 relaxation time of the infarcted myocardium increases markedly at 3 days and remains elevated for 2 months. These changes correlate best with the onset and progression of infarct healing. These data demonstrate the potential of T2-weighted NMR imaging for assessing healing patterns following ischemic myocardial injury.