Bioconjug Chem. 2011 May 18;22(5):859-64 doi: 10.1021/bc2000947. 2011 Apr 19.

Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide

Kuil J, Buckle T, Yuan H, van den Berg NS, Oishi S, Fujii N, Josephson L, van Leeuwen FW.

Abstract

The antagonistic Ac-TZ14011 peptide, which binds to the chemokine receptor 4, has been labeled with a multifunctional single attachment point reagent that contains a DTPA chelate and a fluorescent dye with Cy5.5 spectral properties. Flow cytometry and confocal microscopy showed that the bimodal labeled peptide gave a specific receptor binding that is similar to monofunctionalized peptide derivatives. Therefore, the newly developed bimodal peptide derivative can be used in multimodal imaging applications.

PMID: 21480671