Eur J Vasc Endovasc Surg. 2006 Jan;31(1):28-35 doi: 10.1016/j.ejvs.2005.07.018. 2005 Oct 03.

Embolization-driven occlusion of the abdominal aortic aneurysmal sac as the basis of prevention of endoleaks in a new swine model

Rolland PH, Vidal V, Mekkaoui C, Bertrand MF, Levrier O, Bartoli JM.

Abstract

OBJECTIVES: To assess the effect of a new polymer in embolization of endoleaks using an animal model.
METHODS: A modified aortic stent-graft was placed in 20 pigs. Embolization was performed at the time of graft insertion with non-cytotoxic n-butyl-2-cyanoacrylate-metacryloxysulpholane and lipiodol (0.2:0.8ratio, 2 ml). Angiography, scanning electron microscopy and immuno-histochemistry were obtained at day 0, 1 week and 3 months.
RESULTS: In control animals both type I and II endoleaks were demonstrated. In treated animals, neither type-I nor type-II endoleaks were observed and a fibro-proliferative response was demonstrated within the aneurysm thrombus.
CONCLUSIONS: Host vascular responses govern the fate of the excluded aneurysm. Embolization of the sac and feeding arteries with non-cytotoxic glue sealed all occlusions by stimulating a massive restenosis-like process.

PMID: 16202632
PubMed Entry