J Alzheimers Dis. 2015;43(4):1325-30 doi: 10.3233/JAD-140864.

Cortical localization of microbleeds in cerebral amyloid angiopathy: an ultra high-field 7T MRI study

Ni J, Auriel E, Martinez-Ramirez S, Keil B, Reed AK, Fotiadis P, Gurol EM, Greenberg SM, Viswanathan A.

Abstract

The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear. We examined five consecutive patients with probable CAA and three non-demented elderly subjects with ultra-high field 7T MRI, to identify the precise location of CAA-related CMBs. In five CAA patients, 169 of a total of 170 lobar CMBs were located in cortical areas on 7T MRI, while a precise cortical versus juxtacortical localization was unable to be determined for 50/76 CMBs observed by conventional MRI. 7T MRI demonstrates that nearly all lobar CMBs are located in cortex in CAA.

PMID: 25171715