Development of MRI methods and contrast mechanisms to address biological problems. Past inventions include

  phase contrast flow imaging (1984)

  magnetic resonance angiography with Rheto Meuli (CHUV) (1983-6)

  tensor MRI of myocardial strain (1990)

  MRI of myocardial fiber structure and fiber shortening with WYI Tseng (NTUH) (1993-8)

  diffusion tractography (1995-6)

  high angular resolution diffusion MRI, including Q-ball with Dave Tuch and DSI (1999) (see color icon this page top right)
Other work includes

  MRI dynamic range compression by means of a nonlinear gradient pulse (3D chirp) 

  fast 3D MRA by under sampling of k-space

  discovery of displacement encoding with a stimulated echo (DENSE) with Tim Reese (1995)

  balanced diffusion encoding for suppression of eddy current

  co-developed TrackVis environment with Ruopeng Wang (Martinos Ctr)


Present work is focused on discovery with diffusion MRI of new aspects of geometric order in the CNS, including complex path coherence within the cerebral cortex, and organization of cerebral white matter and connectivity across multiple scales.