Anastasia Yendiki, PhD

Professional Information


Assistant Professor in Radiology, Harvard Medical School
Assistant Physicist, Massachusetts General Hospital


PhD Electrical Engineering: Systems, The University of Michigan, Ann Arbor, MI, 2005

Martinos Faculty


Mailing Address

Building 149, Room 2301
149 13th St.
Charlestown, MA 02129 USA

General Contact Information



My research focuses on methods for mapping the circuitry of the human brain in health and disease. I have developed TRACULA (TRActs Constrained By UnderLying Anatomy), a software tool for reconstructing white-matter pathways from diffusion MRI data based on prior anatomical knowledge. Instead of enforcing hard constraints on the trajectories of the pathways, this approach includes a detailed probabilistic model of the anatomical regions that a pathway traverses at every point along its trajectory. This allows the same pathway to be reconstructed automatically in a novel subject, even if its shape and integrity differs from those of the subjects that were used to train the algorithm. Some of my current research projects include: validation and optimization of diffusion MRI; development of analysis methods for longitudinal diffusion MRI data; and applications in traumatic brain injury and Huntington's disease.