Mar 29, 2017
11:00 AM
Bldg 75 Conference Room



This presentation will cover three separate diffusion-weighted MRI projects that each aim to advance methods for mapping neuronal fibers. First, I will present a practical, model-free, Fourier reconstruction framework for obtaining Diffusion Spectrum Imaging-style probability density and orientation distribution functions from multi-b-shell/non-Cartesian q-space samples. This technique employs q-space sampling density non-uniformity correction and analytic solver. It is demonstrated on data from the Human Connectome Project and shown to be effective and broadly applicable to multi-b-shell data. Using this method, the contribution and combination of information from individual q-space points is elucidated. Second, I will discuss methods for comparing diffusion-weighted MRI measurements with CLARITY 3D histology. Structure tensor texture analysis is adapted from 2D to 3D to recover local primary axon orientations from 3D CLARITY images. The CLARITY axon orientation estimates are compared against diffusion tensor imaging in the same human specimen, and used to perform CLARITY-based tractography in a mouse brain. Finally, I will present a retrospective study that assesses the efficacy of diffusion tractography-based targeting for transcranial MRI-guided focused ultrasound treatment of essential tremor. For 8 patients, the degree of overlap between the tractography-identified target and the focused ultrasound-induced lesion location is found to correlate with clinical outcome.

About the Speaker

Qiyuan Tian is a Ph.D. candidate of the Department of Electrical Engineering and a graduate student research assistant in the research group of Professor Jennifer McNab in the Radiological Sciences Laboratory of the Department of Radiology at Stanford University. He obtained his M.S. in Electrical Engineering from Stanford University in 2013 and the B.Eng. in Communication Science and Engineering from Fudan University in Shanghai, China in 2011. He also studied as an undergraduate exchange student in the Department of Electronic and Computer Engineering at The Hong Kong University of Science and Technology in 2009. Qiyuan’s research lies at developing novel diffusion MRI and neuroimaging acquisition and analysis methods to study the human brain.

Mar 29, 2017
12:00 PM
149 13th Street (Building 149), room 2204

Martinos Special  Mini-Series on Global Warming

Title: Planetary Health: The impacts of Global Environmental Change on Patient and Planet

About the Speaker

Latha Swamy’s work broadly examines the relationship between environmental degradation and human health. Her current research focuses on tropical resources, health systems strengthening and access, food justice and security, gender equity, postcolonialism, and the linkages between these in the midst of global environmental change – particularly their effects on those living in poverty, and innovative solutions that challenge the resulting systems of oppression. She was recruited to her current position as Senior Advisor in Planetary Health to Ernesto Zedillo (Chair of the new Rockefeller Foundation Economic Council on Planetary Health, Director of the Yale Center for the Study of Globalization, and former President of Mexico), and also advises on the Center's Universal Health Coverage Steering Committee.

During her studies at Yale University's School of Forestry and Environmental Studies, Latha worked in India and Nepal with the MIT Abdul Latif Jameel Poverty Action Lab evaluating rural farmers’ social networks to promote new climate-smart agriculture technologies; in Haiti with Hôpital Albert Schweitzer transitioning smallholder farmers to agroforestry techniques to jointly address chronic malnutrition and massive deforestation; and in West Borneo, Indonesia conducting an independent program evaluation at a rural clinic (Health in Harmony) that aims to disincentivize illegal logging by providing reduced cost healthcare services in return for forest stewardship. 

Latha is a Global Health Justice Partnership Fellow at Yale Law School, serves as a UN Ambassador for Women’s Environment and Development Organization, and sits on the Junior Board of EcoHealth Alliance. Latha holds a Master in Environmental Management from Yale University, an M.Sc. in Neuroscience and Clinical Investigation from Albert Einstein College of Medicine, and a B.S. in Cellular Biology with a minor concentration in Percussion and Ethnomusicology from the University of Georgia. 

Apr 06, 2017
03:00 PM


Martinos Special  Mini-Series on Global Warming

One of my greatest fears is that the major strides that the public health community has made over the past 50 years will be derailed by mass-scale ecosystem degradation and anthropogenic environmental change. The crux of planetary health is understanding the human health impacts of environmental change from processes like climate change, biodiversity loss, land use change, wildlife population collapse, among others. In my presentation, I will present my views on the food security and nutritional impacts of terrestrial wildlife and marine fishery declines, drawing both on my collaborative efforts with interdisciplinary researchers and on my independent research programs in Madagascar over the past 17 years. I will also speak about the development of the Planetary Health Alliance, a consortium supporting the growth of a rigorous, policy-focused, transdisciplinary field of applied research aimed at understanding and addressing the human health impacts of anthropogenic environmental change.
About the Speaker:
I am an ecologist and epidemiologist interested in the interface of ecosystem service provisioning and human health, specifically in the context of global trends in biodiversity loss and ecosystem transformation. With a wide range of colleagues at the Harvard School of Public Health, I am studying the human health impacts of ecosystem services. Since 1999, I have been conducting ecological and public health research in Madagascar and am fluent in several local dialects of Malagasy. Most broadly, I am interested in local people’s dependence on natural resources for obtaining adequate health. This interest has led to various studies into connections between marine and terrestrial wildlife consumption and the incidence of micronutrient deficiencies, the importance of botanical ethnomedicines and geophagy to local health, the eco-epidemiology of malaria and the human microbiome given current trends in biodiversity loss and land use change, and the role of green spaces and national parks in benefiting mental health. Through funding from the Wellcome Trust, Rockefeller Foundation, National Science Foundation, and the Darwin Initiative, I am able to work on a breadth of topics under the umbrella of planetary health.