Samantha Holdsworth, Ph.D.
MRI provides excellent contrast between the different soft tissues of the body, which makes it especially useful in imaging brain pathology. The main disadvantage of MRI is that is lengthy, taking up to one hour at our institution. Particularly in a pediatric setting, long protocols increases the risk of motion artifacts in the acquired images at the expense of patient throughput, comfort, and cost.
With the goal of shortening the overall scan time and improving scan fidelity and image contrast, this talk will cover some MRI approaches we are developing for the Stanford Hospital and Clinics and Lucile Packard Children's Hospital.
These methods include: motion-corrected Echo Planar Imaging (EPI) for diffusion-tensor imaging (DTI); a coil-sensitivity corrected dual-echo EPI approach for diffusion-weighted imaging (DWI) and T2 maps; a multi-band readout-segmented (RS)-EPI for DWI/DTI and fluid attenuated recovery (FLAIR) imaging; and 3D short-axis propeller (SAP)-EPI for T1-weighted and T2-weighted imaging.
Using four of these sequences, we are also striving to create a 5 minute motion-corrected pediatric MRI protocol that addresses four of the most conventional clinical MR image contrasts: T1-w, T2-w, DWI, and FLAIR. Preliminary data acquired with this protocol will be shown.