J Am Chem Soc. 2013 Mar 27;135(12):4620-3 doi: 10.1021/ja312610j. 2013 Mar 19.

Redox-activated manganese-based MR contrast agent

Loving GS, Mukherjee S, Caravan P.


Here we report a simple Mn coordination complex with utility as a redox-sensitive MR probe. The HBET ligand stabilizes both the Mn(2+) and Mn(3+) oxidation states. In the presence of glutathione (GSH), low relaxivity Mn(III)-HBET is converted to high relaxivity Mn(II)-HBET with a 3-fold increase in relaxivity, and concomitant increase in MR signal. Alternately, hydrogen peroxide can convert Mn(II)-HBET to Mn(III)-HBET with a reduction in MR signal.

PMID: 23510406