Neurology. 2013 Aug 13;81(7):641-9 doi: 10.1212/WNL.0b013e3182a08ce8. 2013 Jul 17.

Contribution of cortical lesion subtypes at 7T MRI to physical and cognitive performance in MS

Nielsen AS, Kinkel RP, Madigan N, Tinelli E, Benner T, Mainero C.


OBJECTIVES: Evaluate cross-sectionally the contribution of focal cortical lesion (CL) subtypes at ultra-high-field MRI and traditional MRI metrics of brain damage to neurologic disability and cognitive performance in a heterogeneous multiple sclerosis (MS) cohort.
METHODS: Thirty-four patients with early or established disease including clinically isolated syndrome, relapsing-remitting MS, and secondary progressive MS were scanned on a human 7-tesla (7T) (Siemens) scanner to acquire fast low-angle shot (FLASH) T2*-weighted images for characterization of white matter and deep gray matter lesion volume, and CL types. Patients also underwent anatomical 3T MRI for cortical thickness estimation, and neuropsychological testing within 1 week of the 7T scan. Twenty-seven patient scans were acceptable for further analysis. Neurologic disability was measured using the Expanded Disability Status Scale.
RESULTS: Type III-IV CLs had the strongest relationship to physical disability (ρ = 0.670, p CONCLUSIONS: Leukocortical (type I) and subpial (III-IV) CLs identified on 7T FLASH-T2* sequences are potential cortical biomarkers of cognitive and neurologic status in MS.

PMID: 23864311