AIDS. 2013 Aug 14. doi: 10.1097/01.aids.0000433244.32105.96. [Epub ahead of print]

Structure-specific glial response in a macaque model of neuroAIDS: multivoxel proton magnetic resonance spectroscopic imaging at 3 Tesla

Wu WE, Tal A, Zhang K, Babb JS, Ratai EM, Gonzalez RG, Gonen O.

Abstract

OBJECTIVE:: As approximately 40% of persons with HIV also suffer neurocognitive decline, we sought to assess metabolic dysfunction in the brains of simian immunodeficiency virus (SIV)-infected rhesus macaques, an advanced animal model, in structures involved in cognitive function. We test the hypothesis that SIV-infection produces proton-magnetic resonance spectroscopic imaging (H-MRSI)-observed decline in the neuronal marker, N-acetylaspartate (NAA) and elevations in the glial marker, myo-inositol (mI) and associated creatine (Cr) and choline (Cho) in these structures. DESIGN:: Pre and 4-6 weeks post-SIV infection (with CD8 lymphocyte depletion) was monitored with T2-weighted quantitative MRI and 16 x 16 x 4 multivoxel H-MRSI (TE/TR = 33/1400 ms) in the brains of five rhesus macaques. METHODS:: Exploiting the high-resolution H-MRSI grid, absolute, cerebrospinal fluid partial volume-corrected NAA, Cr, Cho and mI concentrations were obtained from centrum semiovale, caudate nucleus, putamen, thalamus and hippocampus. RESULTS:: Pre to post-infection mean Cr increased in the thalamus: 7.2 +/- 0.4 to 8.0 +/- 0.8 mmol/l (+11%, P

PMID: 23939235