Proc Natl Acad Sci U S A. 1994 May 24;91(11):4887-91

Scattering of diffuse photon density waves by spherical inhomogeneities within turbid media: analytic solution and applications

Boas DA, O'Leary MA, Chance B, Yodh AG.

Abstract

We present an analytic solution for the scattering of diffuse photon density waves by spherical inhomogeneities within turbid media. The analytic result is compared to experimental measurements. Close agreement between theory and experiment permits the use of the theory to determine the properties of unknown sphere-like objects embedded in turbid media. The analytic solution is extended to encompass several problems of practical interest in imaging, including the influence of multiple sources, multiple objects, and boundaries on the characterization of spherical inhomogeneities. We also extend the solution to encompass time-domain measurements.

PMID: 8197151