J Psychopharmacol. 2002 Jun;16(2):163-7

Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence

Elman I, Karlsgodt KH, Gastfriend DR, Chabris CF, Breiter HC.


Several lines of evidence suggest a link between cocaine-primed craving and depressive symptomatology. The purpose of this study was to directly relate these two clinical phenomena. Thirty-three cocaine-dependent subjects were rated on the Hamilton Rating Scale for Depression (HRSD) at baseline and then administered an i.v. bolus of cocaine (0.2 mg/kg). Multiple regression analysis revealed that only the HRSD score was an independent predictor of cocaine-primed craving (F= 4.09; d.f. = 10,22; r = 0.81, p

PMID: 12095075