1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers

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Neurology
1998 May
50
5
1357-65
Journal Articles
PubMed ID: 
9595987

Huntington's disease (HD) is the result of an expanded (CAG) repeat in a gene on chromosome 4. A consequence of the gene defect may be progressive impairment of energy metabolism. We previously showed increased occipital cortex lactate in HD using localized 1H spectroscopy. We have now extended these studies to show an almost threefold elevation in occipital cortex lactate in 31 HD patients as compared with 17 normal control subjects (p

Year: 
1998