Welcome to the MGH FTD Unit
It has been known for decades that some FTD runs in families as a
hereditary illness. Yet as is the case for the majority of FTD research,
most of what we know has been learned in the past 10-15 years. This is
particularly true for genetics. The first gene associated with FTD, the
MAPT gene which makes tau protein, was discovered in 1998. The second
major gene, progranulin, was discovered in 2006. The third major gene,
C9ORF72, was discovered in 2011. There are other less common genes as
well, and undoubtedly more to discover.
Our research currently focuses on the development of better understanding of the relationship between alterations in brain structure and function prior to and accompanying the development of symptoms of FTD. We ultimately aim to identify biomarkers of the disease in people without symptoms, and to use these biomarkers to help in the development of new treatments.
Our research is generously funded by the National Institute of Neurological Disorders and Stroke and private philanthrophy.
Please read our introductory fact sheet for more information and do not hesitate to contact us to discuss any questions you may have. Thank you.
Email us to discuss your questions or interests. An important piece of background information is to write down the details of your family history/family tree and collect information on anyone in your family who may have been affected by FTD or a related illness, which may or may not have been diagnosed correctly.