Iman Aganj, PhD

 

Assistant Professor of Radiology, Harvard Medical School

Associate Investigator, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital

Google Scholar

Journal Articles

IEEE Transactions on Medical Imaging pubmed
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I. Aganj and B. Fischl, “Multi-atlas image soft-segmentation via computation of the expected label value,” IEEE Transactions on Medical Imaging, vol. 40, no. 6, pp. 1702–1710, 2021.
IEEE Transactions on Medical Imaging
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A. Frau-Pascual, J. Augustinack, D. Varadarajan, A. Yendiki, D. H. Salat, B. Fischl, and I. Aganj, “Conductance-based structural brain connectivity in aging and dementia,” Brain Connectivity, vol. 11, no. 7, pp. 566–583, 2021.
JAD
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S. Koley, P. K. Dutta, and I. Aganj, “Radius-optimized efficient template matching for lesion detection from brain images,” Scientific Reports, vol. 11, Article no. 11586, 2021.
NeuroImage_logo C. Liu, W. Ammon, V. Siless, M. Fogarty, R. Wang, A. Atzeni, I. Aganj, J. E. Iglesias, L. Zollei, B. Fischl, J. D. Schmahmann, and H. Wang, “Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution,” NeuroImage, in press, 2021.
NeuroImage_logo
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D. Abramian, M. Larsson, A. Eklund, I. Aganj, C.-F. Westin, and H. Behjat, “Diffusion-informed spatial smoothing of fMRI data in white matter using spectral graph filters,” NeuroImage, vol. 237, Article no. 118095, 2021.
RSNA pubmed M. A. Morales, D. Izquierdo-Garcia, I. Aganj, J. Kalpathy-Cramer, B. R. Rosen, and C. Catana, “Implementation and validation of a three-dimensional cardiac motion estimation network,” Radiology: Artificial Intelligence, vol. 1, no. 4, 2019.
NeuroImage_logo pubmedsoftware A. Frau-Pascual, M. Fogarty, B. Fischl, A. Yendiki, and I. Aganj, “Quantification of structural brain connectivity via a conductance model,” NeuroImage, vol. 189, pp. 485–496, 2019.
JAD pubmed
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I. Aganj, “Automatic verification of the gradient table in diffusion-weighted MRI based on fiber continuity,” Scientific Reports, vol. 8, Article no. 16541, 2018.
JAD pubmed
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I. Aganj, M. G. Harisinghani, R. Weissleder, and B. Fischl, “Unsupervised medical image segmentation based on the local center of mass,” Scientific Reports, vol. 8, Article no. 13012, 2018.
JAD   W. J. Lee, C. E. Han, I. Aganj, S. W. Seo, and J.-K. Seong, “Distinct patterns of rich club organization in Alzheimer’s disease and subcortical vascular dementia: a white matter network study,” Journal of Alzheimer’s Disease, vol. 63, no. 3, 2018.
NeuroImage_logo pubmed H. Wang, C. Magnain, R. Wang, J. Dubb, A. Varjabedian, L. S. Tirrell, A. Stevens, J. C. Augustinack, E. Konukoglu, I. Aganj, M. P. Frosch, J. D. Schmahmann, B. Fischl, and D. A. Boas, “as-PSOCT: volumetric microscopic imaging of human brain architecture and connectivity,” NeuroImage, vol. 165, pp. 56–68, 2018.
IEEE SPL pubmedsoftware I. Aganj and B. Fischl, “Multimodal image registration through simultaneous segmentation,” IEEE Signal Processing Letters, vol. 24, no. 11, pp. 1661–1665, 2017.
NeuroImage_logo pubmed T. Tong, I. Aganj, T. Ge, J. R. Polimeni, and B. Fischl, “Functional density and edge maps: characterizing functional architecture in individuals and improving cross-subject registration,” NeuroImage, vol. 158, pp. 346–355, 2017.
NeuroImage_logo pubmed software I. Aganj, J. E. Iglesias, M. Reuter, M. R. Sabuncu, and B. Fischl, “Mid-space-independent deformable image registration,” NeuroImage, vol. 152, pp. 158–170, 2017.

MP

pubmedsoftware

A. Gholipour, O. Afacan, I. Aganj, B. Scherrer, S. P. Prabhu, M. Sahin, and S. K. Warfield, “Super-resolution reconstruction in frequency, image, and wavelet domains to reduce through-plane partial voluming in MRI,” Medical Physics, vol. 42, pp. 6919–6932, 2015.

PNAS

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J. L. Gaglia, M. Harisinghani, I. Aganj, G. R. Wojtkiewicz, S. Hedgire, C. Benoist, D. Mathis, and R. Weissleder, “Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients,” Proceedings of the National Academy of Sciences, vol. 112, pp. 2139–2144 , 2015.

NeuroImage_logo

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I. Aganj, M. Reuter, M. R. Sabuncu, and B. Fischl, “Avoiding symmetry-breaking spatial non-uniformity in deformable image registration via a quasi-volume-preserving constraint,” NeuroImage, vol. 106, pp. 238–251, 2015.

NeuroImage_logo

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J. E. Iglesias, M. R. Sabuncu, I. Aganj, P. Bhatt, C. Casillas, D. Salat, A. Boxer, B. Fischl, and K. Van Leemput, “An algorithm for optimal fusion of atlases with different labeling protocols,” NeuroImage, vol. 106, pp. 451–463, 2015.

NeuroImage

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G. Prasad, S. Joshi, N. Jahanshad, J. Villalon, I. Aganj, C. Lenglet, G. Sapiro, K. McMahon, G. de Zubicaray, N. Martin, M. Wright, A. Toga., and P. Thompson, “Automatic clustering and population analysis of white matter tracts using maximum density paths,” NeuroImage, vol. 97, pp. 284–295, 2014.

imageprocessing

pubmed

I. Aganj, B. T. T. Yeo, M. R. Sabuncu, and B. Fischl, “On removing interpolation and resampling artifacts in rigid image registration,” IEEE Transactions on Image Processing, vol. 22, no. 2, pp. 816–827, 2013.

ijbi-logo

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E. Caruyer, I. Aganj, C. Lenglet, G. Sapiro, and R. Deriche, “Motion detection in diffusion MRI via online ODF estimation,” International Journal of Biomedical Imaging, vol. 2013, Article ID 849363, 2013.

pubmedsoftware

I. Aganj, C. Lenglet, E. Yacoub, G. Sapiro, and N. Harel, “A 3D wavelet fusion approach for the reconstruction of isotropic-resolution MR images from orthogonal anisotropic-resolution scans,” Magnetic Resonance in Medicine, vol. 67, no. 4, pp. 1167–1172, 2012.

pubmedsoftware

I. Aganj, C. Lenglet, N. Jahanshad, E. Yacoub, N. Harel, P. Thompson, and G. Sapiro, “A Hough transform global probabilistic approach to multiple-subject diffusion MRI tractography,” Medical Image Analysis, vol. 15, no. 4, pp. 414–425, 2011.

pubmed
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I. Aganj, C. Lenglet, G. Sapiro, E. Yacoub, K. Ugurbil, and N. Harel, “Reconstruction of the orientation distribution function in single and multiple shell q-ball imaging within constant solid angle,” Magnetic Resonance in Medicine, vol. 64, no. 2, pp. 554–566, 2010.

pubmedsoftware

I. Aganj, G. Sapiro, N. Parikshak, S. K. Madsen, and P. Thompson, “Measurement of cortical thickness from MRI by minimum line integrals on soft-classified tissue,” Human Brain Mapping, vol. 30, no. 10, pp. 3188–3199, 2009.

pubmed

R. Narasimha, I. Aganj, A. Bennett, M. Borgnia, D. Zabransky, G. Sapiro, S. McLaughlin, J. Milne, and S. Subramaniam, “Evaluation of denoising algorithms for biological electron tomography,” Journal of Structural Biology, vol. 164, no. 1, pp. 7–17, 2008.

 

Book Chapter

BrainMapping

 

I. Aganj, G. Sapiro, and N. Harel, “Q-space modeling in diffusion-weighted MRI,” in Brain Mapping, A. W. Toga, Ed., Waltham: Academic Press, 2015, pp. 257–263.

Conference Articles

H. Behjat, C.-F. Westin, and I. Aganj, “Cortical surface-informed volumetric spatial smoothing of fMRI data via graph signal processing,” in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2021.

H. Behjat, I. Aganj, D. Abramian, A. Eklund, and C.-F. Westin, “Characterization of spatial dynamics of fMRI data in white matter using diffusion-informed white matter harmonics,” in Proceedings of the IEEE International Symposium on Biomedical Imaging, pp. 1586–1590, Nice, France, 2021.

pubmed

I. Aganj, A. Frau-Pascual, J. E. Iglesias, A. Yendiki, J. Augustinack, D. Salat, and B. Fischl, “Compensatory brain connection discovery in Alzheimer’s disease,” in Proceedings of the IEEE International Symposium on Biomedical Imaging, pp. 283–287, Iowa City, IA, 2020.


software

A. Frau-Pascual, J. Augustinack, D. Varadarajan, A. Yendiki, B. Fischl, and I. Aganj, “Detecting structural brain connectivity differences in dementia through a conductance model,” in Proceedings of the 53rd Asilomar Conference on Signals, Systems, and Computers, pp. 591–595, Pacific Grove, CA, 2019.

pubmedsoftware

I. Aganj and B. Fischl, “Expected label value computation for atlas-based image segmentation,” in Proceedings of the IEEE International Symposium on Biomedical Imaging, pp. 334–338, Venice, Italy, 2019.

BrainLes

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S. Koley, C. Chakraborty, C. Mainero, B. Fischl, and I. Aganj, “A fast approach to automatic detection of brain lesions,” in Proceedings of the MICCAI Brain Lesions Workshop, pp. 52–61, Athens, Greece, 2016.

WBIR

 pubmed

Y. Zhang, I. Aganj, A. van der Kouwe, and M. D. Tisdall, “Effects of resolution and registration algorithm on the accuracy of EPI vNavs for real time head motion correction in MRI,” in Proceedings of the 7th International Workshop on Biomedical Image Registration (held in conjunction with IEEE CVPR), pp. 583–591, Las Vegas, NV, 2016.

pubmed

software

I. Aganj, J. E. Iglesias, M. Reuter, M. R. Sabuncu, and B. Fischl, “Mid-space-independent symmetric data term for pairwise deformable image registration,” in Proceedings of the 18th International Conference on Medical Image Computing and Computer Assisted Intervention, pp. 263–271, Munich, Germany, 2015.

pubmed

I. Aganj, M. Reuter, M. R. Sabuncu, and B. Fischl, “Symmetric non-rigid image registration via an adaptive quasi-volume-preserving constraint,” in Proceedings of the IEEE International Symposium on Biomedical Imaging, pp. 234–237, San Francisco, CA, 2013.

MICCAI

 

A. Kamath, I. Aganj, J. G. Xu, E. Yacoub, K. Ugurbil, G. Sapiro, and C. Lenglet, “Generalized constant solid angle ODF and optimal acquisition protocol for fiber orientation mapping,” in Proceedings of the MICCAI Workshop on Computational Diffusion MRI, pp. 67–78, Nice, France, 2012.

E. Caruyer, I. Aganj, C. Lenglet, G. Sapiro, and R. Deriche, “Online motion detection in high angular resolution diffusion imaging,” in Proceedings of the Eighth IEEE International Symposium on Biomedical Imaging, pp. 516–519, Chicago, IL, 2011.

N. Jahanshad, I. Aganj, C. Lenglet, A. Joshi, Y. Jin, M. Barysheva, K. McMahon, G. de Zubicaray, N. Martin, M. Wright, A. Toga, G. Sapiro, and P. Thompson, “Sex differences in the human connectome: 4-Tesla high angular resolution diffusion imaging (HARDI) tractography in 234 young adult twins,” in Proceedings of the Eighth IEEE International Symposium on Biomedical Imaging, pp. 939–943, Chicago, IL, 2011.

pubmed

G. Prasad, N. Jahanshad, I. Aganj, C. Lenglet, G. Sapiro, A. Toga, and P. Thompson, “Atlas-based fiber clustering for multi-subject analysis of high angular resolution diffusion imaging tractography,” in Proceedings of the Eighth IEEE International Symposium on Biomedical Imaging, pp. 276–280, Chicago, IL, 2011.

L. Zhan, A. Leow, I. Aganj, C. Lenglet, G. Sapiro, E. Yacoub, N. Harel, A. Toga, and P. Thompson, “Differential information content in staggered multiple shell HARDI measured by the tensor distribution function,” in Proceedings of the Eighth IEEE International Symposium on Biomedical Imaging, pp. 305–309, Chicago, IL, 2011.

Y. Jin, Y. Shi, N. Jahanshad, I. Aganj, G. Sapiro, A. Toga, and P. Thompson, “3D elastic registration improves HARDI-derived fiber alignment and automated tract clustering,” in Proceedings of the Eighth IEEE International Symposium on Biomedical Imaging, pp. 822–826, Chicago, IL, 2011.

MICCAI

 

G. Prasad, S. Joshi, N. Jahanshad, J. Villalon, I. Aganj, C. Lenglet, G. Sapiro, K. McMahon, G. de Zubicaray, N. Martin, M. Wright, A. Toga, and P. Thompson, “White matter tract analysis in 454 adults using maximum density paths,” in Proceedings of the MICCAI Workshop on Computational Diffusion MRI, Toronto, Canada, pp. 1–12, Toronto, Canada, 2011.

pubmed
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I. Aganj, C. Lenglet, and G. Sapiro, “ODF maxima extraction in spherical harmonic representation via analytical search space reduction,” in Proceedings of the Thirteenth International Conference on Medical Image Computing and Computer Assisted Intervention, pp. 84–91, Beijing, China, 2010.


E. Caruyer, I. Aganj, C. Lenglet, G. Sapiro, and R. Deriche, “Online orientation distribution function reconstruction in constant solid angle and its application to motion detection in HARDI,” in Proceedings of the Seventh IEEE International Symposium on Biomedical Imaging, Rotterdam, Netherlands, pp. 812–815, 2010.

pubmed
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I. Aganj, C. Lenglet, G. Sapiro, E. Yacoub, K. Ugurbil, and N. Harel, “Multiple q-shell ODF reconstruction in q-ball imaging,” in Proceedings of the Twelfth International Conference on Medical Image Computing and Computer Assisted Intervention, pp. 423–431, London, UK, 2009.

pubmed
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I. Aganj, C. Lenglet, and G. Sapiro, “ODF reconstruction in q-ball imaging with solid angle consideration,” in Proceedings of the Sixth IEEE International Symposium on Biomedical Imaging, pp. 1398–1401, Boston, MA, 2009.

pubmed
software

I. Aganj, G. Sapiro, N. Parikshak, S. K. Madsen, and P. Thompson, “Segmentation-free measurement of cortical thickness from MRI,” in Proceedings of the Fifth IEEE International Symposium on Biomedical Imaging, pp. 1625–1628, Paris, France, 2008.

D. Rother, K. Patwardhan, I. Aganj, and G. Sapiro, “3D priors for scene learning from a single view,” in Proceedings of the IEEE Workshop on Search in 3D (held in conjunction with CVPR), pp. 1–8, Anchorage, AK, 2008.


I. Aganj, A. Bartesaghi, M. Borgnia, H.Y. Liao, G. Sapiro, and S. Subramaniam, “Regularization for inverting the Radon transform with wedge consideration,” in Proceedings of the Fourth IEEE International Symposium on Biomedical Imaging, pp. 217–220, Arlington, VA, 2007.

R. Narasimha, I. Aganj, M. Borgnia, G. Sapiro, S. McLaughlin, J. Milne, and S. Subramaniam, “From gigabytes to bytes: Automated denoising and feature identification in electron tomograms of intact bacterial cells,” in Proceedings of the Fourth IEEE International Symposium on Biomedical Imaging, pp. 304–307, Arlington, VA, 2007.

 

Conference Abstracts

software

M. Mohammadi, A. Frau-Pascual, I. Aganj, J. Beaujoin, F. Lechanoine, T. Jacqueson, F. Poupon, C. Poupon, C. Destrieux, and F. Andersson, “High-resolution ex-vivo structural brainstem connectivity estimated via a conductance model,” in Proceedings of the Annual Meeting of the Organization for Human Brain Mapping, Montréal, Canada, 2020.

SPIE Photonics West

 

H. Wang, V. Siless, M. Fogarty, I. Aganj, D. Greve, and B. Fischl, “The optical property and morphometry of human cerebellum cortex with automatic serial sectioning polarization sensitive optical coherence tomography,” in Proceedings of the SPIE Photonics West, San Francisco, CA, 2020.

SfN

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D. Kothapalli, M. A. Tubi, S. I. Thomopoulos, I. Aganj, M. D. Sweeney, L. S. Schneider, E. B. Joe, J. M. Ringman, H. Yassine, M. G. Harrington, B. V. Zlokovic, A. W. Toga, H. C. Chui, P. M. Thompson, and M. N. Braskie, “Automated measurement of medial temporal lobe subregion cortical thickness using minimum line integrals,” in Proceedings of the 49th Annual Meeting of the Society for Neuroscience, Chicago, IL, 2019.

software

A. Frau-Pascual, A. Yendiki, B. Fischl, and I. Aganj, “Global quantification of structural brain connectivity,” in Proceedings of the Annual Meeting of the Organization for Human Brain Mapping, Singapore, 2018.

pubmed

Y. Zhang, I. Aganj, A. van der Kouwe, and M. D. Tisdall, “Accurate high-speed 3D-registration of EPI vNavs for head motion correction,” in Proceedings of the Twenty Fifth Annual Meeting of the International Society for Magnetic Resonance in Medicine, Honolulu, HI, 2017.

software

I. Aganj, G. Prasad, P. Srinivasan, A. Yendiki, P. M. Thompson, and B. Fischl, “Structural brain network augmentation via Kirchhoff's laws,” in Proceedings of the Joint Annual Meeting of ISMRM-ESMRMB, Milan, Italy, 2014.

 software

A. Gholipour, O. Afacan, I. Aganj, and S. Warfield, “Super-resolution MRI reconstruction in image, frequency, and wavelet domains,” in Proc. Joint Annual Meeting of ISMRM-ESMRMB, Milan, Italy, 2014.

SfN

software

G. Prasad, I. Aganj, and P. Thompson, “Synthesizing connectivity networks to improve classification of Alzheimer's disease,” in Proceedings of the 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA, 2013.

 

A. Kamath, I. Aganj, J. Xu, E. Yacoub, K. Ugurbil, G. Sapiro, and C. Lenglet, “Optimal acquisition protocol for white matter fiber orientation mapping using generalized CSA-ODF reconstruction,” in Proc. Twenty First Annual Meeting of International Society for Magnetic Resonance in Medicine, 2013.

 

G. Prasad, S. Joshi, N. Jahanshad, J. Villalon, I. Aganj, C. Lenglet, G. Sapiro, K. McMahon, G. de Zubicaray, N. Martin, M. Wright, A. Toga, and P. Thompson, “Genetic analysis of fibers in white matter pathways from HARDI images,” in Proceedings of the Eighteenth Annual Meeting of the Organization for Human Brain Mapping, 2012.

software

I. Aganj, C. Lenglet, E. Yacoub, G. Sapiro, and N. Harel, “A wavelet fusion approach to the reconstruction of isotropic-resolution MR images from anisotropic orthogonal scans,” in Proceedings of the Nineteenth Annual Meeting of the International Society for Magnetic Resonance in Medicine, 2011.

E. Caruyer, I. Aganj, C. Lenglet, G. Sapiro, and R. Deriche, “Online reconstruction and motion detection in HARDI,” in Proceedings of the Nineteenth Annual Meeting of the International Society for Magnetic Resonance in Medicine, 2011.

 

N. Jahanshad, I. Aganj, C. Lenglet, G. Sapiro, A. Toga, K. McMahon, G. de Zubicaray, N. Martin, M. Wright, and P. Thompson, “4-Tesla high angular resolution diffusion tractography analysis of the human connectome in 234 subjects: Sex differences and EPI distortion effects,” in Proceedings of the Nineteenth Annual Meeting of the International Society for Magnetic Resonance in Medicine, 2011.

software

S. N. Sotiropoulos, I. Aganj, S. Jbabdi, G. Sapiro, C. Lenglet, and T. E. Behrens, “Inference on constant solid angle orientation distribution functions from diffusion-weighted MRI,” in Proceedings of the Seventeenth Annual Meeting of the Organization for Human Brain Mapping, 2011.

G. Prasad, N. Jahanshad, I. Aganj, C. Lenglet, G. Sapiro, A. W. Toga, and P. M. Thompson, “Atlas-based fiber clustering for multi-subject HARDI tractography,” in Proceedings of the Seventeenth Annual Meeting of the Organization for Human Brain Mapping, 2011.

 

L. Zhan, J. J. GadElkarim, A. D. Leow, I. Aganj, C. Lenglet, G. Sapiro, N. Harel, A. W. Toga, and P. M. Thompson, “Probabilistic tractography using the tensor distribution function in multiple-shell HARDI,” in Proceedings of the Seventeenth Annual Meeting of the Organization for Human Brain Mapping, 2011.


I. Aganj, N. Jahanshad, C. Lenglet, A. W. Toga, K. L. McMahon, G. I. de Zubicaray, M. J. Wright, N. G. Martin, G. Sapiro, and P. Thompson, “Relating fiber crossing in HARDI to intellectual function,” in Proceedings of the Sixteenth Annual Meeting of the Organization for Human Brain Mapping, 2010.

 

L. Zhan, A. D. Leow, I. Aganj, C. Lenglet, G. Sapiro, N. Harel, A. W. Toga, and P. Thompson, “Tensor distribution function in multiple shell high angular resolution diffusion imaging,” in Proceedings of the Sixteenth Annual Meeting of the Organization for Human Brain Mapping, 2010.


software

I. Aganj, C. Lenglet, G. Sapiro, M. C. Chiang, and P. Thompson, “Multi-subject diffusion MRI tractography via a Hough transform global approach,” in Proceedings of the Fifteenth Annual Meeting of the Organization for Human Brain Mapping, 2009.


software

I. Aganj, C. Lenglet, and G. Sapiro, “Accurate ODF reconstruction in q-ball imaging,” in Proceedings of the Fifteenth Annual Meeting of the Organization for Human Brain Mapping, 2009.

software

I. Aganj, C. Lenglet, R. Keriven, G. Sapiro, N. Harel, and P. Thompson, “A Hough transform global approach to diffusion MRI tractography,” in Proceedings of the Seventeenth Annual Meeting of the International Society for Magnetic Resonance in Medicine, 2009.