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Aasted, C.M., Yücel, M.A., Cooper, R.J., Dubb, J., Tsuzuki, D., Becerra, L., Petkov, M.P., Borsook, D., Dan, I., Boas, D.A. (2015). “Anatomical guidance for functional near-infrared spectroscopy: AtlasViewer tutorial.” Neurophotonics 2(2), 020801 

Becerra, L.R., Aasted, C.M., Boas, D.A., George, E., Yücel, M.A., Kussman, B.D., Kelsey, P. and Borsook, D. (2015) "“Brain Measures of Nociception using Near Infrared Spectroscopy in Patients Undergoing Routine Screening Colonoscopy”." Pain. PMID: 26645550

Deng, B., Brooks, D.H., Boas, D.A, Lundqvist, M., and Fang. (2015). "Characterization of structural-prior guided optical tomography using realistic breast models derived from dual-energy x-ray mammography." Biomedical Optics Express 6(7), 2366-2379

Deng, B., Fradkin, M., Rouet, J.M., Moore, R.H., Kopans, D.B., Boas, D.A., Lundqvist, M. and Fang, Q. (2015). "Characterizing breast lesions through robust multimodal data fusion using independent diffuse optical and x-ray breast imaging." J Biomed Opt 20(8): 80502. PMID: 26263413

Gagnon, L., Sakadzic, S., Lesage, F., Musacchia, J.J., Lefebvre, J., Fang, Q., Yucel, M.A., Evans, K.C., Mandeville, E.T., Cohen-Adad, J., Polimeni, J.R., Yaseen, M.A., Lo, E.H., Greve, D.N., Buxton, R.B., Dale, A.M., Devor, A. and Boas, D.A. (2015). "Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe." J Neurosci 35(8): 3663-75. PMID: 25716864. PMID: 25716864. PMC ID: 4339366

C. Magnain, J. C. Augustinack, E. Konukoglu, M. P. Frosch, S. Sakadzic, A. Varjabedian, N. Garcia, V. J. Wedeen, D. A. Boas and B. Fischl (2015). "Optical coherence tomography visualizes neurons in human entorhinal cortex." Neurophotonics 2(1): 015004. PMID: 25741528. PMC ID: 4346095

S. Sakadzic, J. Lee, D. A. Boas and C. Ayata (2015). "High-resolution in vivo optical imaging of stroke injury and repair." Brain Res. PMID: 25960347

Selb, J., Yücel, M.A., Phillip, D., Schytz, H.W., Iversen, H.K., Vangel, M., Ashina, M. and Boas, D.A. (2015) "“Effect of motion artifacts and their correction on near-infrared spectroscopy oscillation data: a study in healthy subjects and stroke patients.”" J Biomed Opt. 20(5):56011. PMID: 26018790

von Bornstadt, D., Houben, T., Seidel, J.L., Zheng, Y., Dilekoz, E., Qin, T., Sandow, N., Kura, S., Eikermann-Haerter, K., Endres, M., Boas, D.A., Moskowitz, M.A., Lo, E.H., Dreier, J.P., Woitzik, J., Sakadzic, S. and Ayata, C. (2015). "Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations." Neuron 85(5): 1117-31. PMID: 25741731. PMC ID: 4351476

Yücel, M.A., Aasted, C.M., Petkov, M.P., Borsook, D., Boas, D.A. and Becerra, L. (2015) "“Specificity of Hemodynamic Brain Responses to Painful Stimuli: A functional near-infrared spectroscopy study." ”Scientific Reports, 30; 5:9469. PMID: 25820289

Yücel, M.A., Selb, J., Aasted, C.M., Petkov, M.P., Becerra, L., Borsook, D. and Boas, D.A. (2015) "“Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses.”" Neurophotonics, 2(3): 035005.


Augustinack, J.C., Magnain, C., Reuter, M., van der Kouwe, A.J., Boas, D. and Fischl, B. (2014). "MRI parcellation of ex vivo medial temporal lobe." Neuroimage 93 Pt 2: 252-9. PMID: 23702414

Boas, D.A, Elwell, C.E., Ferrari, M. and Taga, G.  (2014). "Twenty years of functional near-infrared spectroscopy: introduction for the special issue." Neuroimage 85 Pt 1: 1-5. PMID: 24321364

Buss, A.T., Fox, N., Boas, D.A. and Spencer, J.P. (2014). “Probing the Early Development of Visual Working Memory Capacity with Functional Near-Infrared Spectroscopy.” NeuroImage 85 Pt 1: 314–25. PMID: 23707803

Lee, J., Jiang, J.Y., Wu, W., Lesage, F. and Boas, D.A. (2014). "Statistical intensity variation analysis for rapid volumetric imaging of capillary network flux." Biomed Opt Express 5(4): 1160-72. PMID: 24761298

Sakadzic, S., Mandeville, E.T., Gagnon, L., Musacchia, J.J., Yaseen, M.A., Yucel, M.A., Lefebvre, J., Lesage, F., Dale, A.M., Eikermann-Haerter, K., Ayata, C., Srinivasan, V.J., Lo, E.H., Devor, A. and Boas, D.A. (2014). "Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue." Nat Commun 5: 5734. PMID: 25483924 (Supp. Materials)

Selb, J., Ogden, T.M., Dubb, J., Fang, Q. and Boas, D.A. (2014). "Comparison of a layered slab and an atlas head model for Monte Carlo fitting of time-domain near-infrared spectroscopy data of the adult head." J Biomed Opt 19(1): 16010. PMID: 24407503

Wilcox, T., Hawkins, L.B., Hirshkowitz, A. and Boas, D.A. (2014). "Cortical activation to object shape and speed of motion during the first year." Neuroimage 99: 129-41. PMID: 24821531

Yücel, M.A., Evans, K.C., Selb, J., Huppert, T.J., Boas, D.A. and Gagnon, L. (2014) "“Validation of the hypercapnic calibrated fMRI method using DOT-fMRI fusion imaging.”" NeuroImage 02 Pt 2:729-35. PMID: 25196509

Yucel, M.A., Selb, J., Boas, D.A., Cash, S.S. and Cooper, R.J. (2014). "Reducing motion artifacts for long-term clinical NIRS monitoring using collodion-fixed prism-based optical fibers." Neuroimage 85 Pt 1: 192-201. PMID: 23796546


Carp, S.A., Sajjadi, A.Y., Wanyo, C.M., Fang, Q., Specht, M.C., Schapira, L., Moy, B., Bardia, A., Boas, D.A. and Isakoff, S.J. (2013). "Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system." Biomed Opt Express 4(12): 2911-24. PMID: 24409390

Dehaes, M., Aggarwal, A., Lin, P.Y., Rosa Fortuno, C., Fenoglio, A., Roche-Labarbe, N., Soul, J.S., Franceschini, M.A. and Grant, P.E. (2013). "Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia." J Cereb Blood Flow Metab. PMID: 24064492

Devor, A., Bandettini, P.A., Boas, D.A., Bower, J.M., Buxton, R.B., Cohen, L.B., Dale, A.M., Einevoll, G.T., Fox, P.T., Franceschini, M.A., Friston, K.J., Fujimoto, J.G., Geyer, M.A., Greenberg, J.H., Halgren, E., Hamalainen, M.S., Helmchen, F., Hyman, B.T., Jasanoff, A.,Jernigan,  T.L., Judd, L.L., Kim, S.G., Kleinfeld, D., Kopell, N.J., Kutas, M., Kwong, K.K., Larkum, M.E., Lo, E.H., Magistretti, P.J., Mandeville, J.B., Masliah, E., Mitra, P.P., Mobley, W.C., Moskowitz, M.A., Nimmerjahn, A., Reynolds, J.H., Rosen, B.R., Salzberg, B.M., Schaffer, C.B., Silva, G.A., So, P.T., Spitzer, N.C., Tootell., R.B., Van Essen, D.C., Vanduffel, W., Vinogradov, S.A., Wald, L.L., Wang, L.V., Weber, B. and Yodh, A.G. (2013). "The challenge of connecting the dots in the B.R.a.I.N." Neuron 80(2): 270-4. PMID: 24139032

Erdogan, S.B., Yucel, M.A. and Akin, A. (2013). "Analysis of task-evoked systemic interference in fNIRS measurements: Insights from fMRI." Neuroimage. PMID: 24148922

Gagnon, L., Yucel, M.A., Boas, D.A. and Cooper, R.J. (2013). "Further improvement in reducing superficial contamination in NIRS using double short separation measurements." Neuroimage. PMID: 23403181

Lee, J., Radhakrishnan, H., Wu, W., Daneshmand, A., Climov, M., Ayata, C. and Boas, D.A. (2013). "Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography." J Cereb Blood Flow Metab (33): 819-825. PMID: 23403378

Lee, J., Wu, W., Lesage, F. and Boas, D.A.  (2013). "Multiple-capillary measurement of RBC speed, flux, and density with optical coherence tomography." J Cereb Blood Flow Metab 33(11): 1707-10. PMID: 24022621

Lin, P.Y., Roche-Labarbe, N., Dehaes, M., Carp, S., Fenoglio, A., Barbieri, B., Hagan, K., Grant, P.E. and Franceschini, M.A. (2013). "Non-invasive optical measurement of cerebral metabolism and hemodynamics in infants." J Vis Exp (73): e4379. PMID: 23524854

Lin, P.Y., Roche-Labarbe, N., Dehaes, M., Fenoglio, A., Grant, P.E. and Franceschini, M.A.  (2013). "Regional and hemispheric asymmetries of cerebral hemodynamic and oxygen metabolism in newborns." Cereb Cortex 23(2): 339-48. PMID: 22328446

Magnain, C., Augustinack, J.C., Reuter, M., Wachinger, C., Frosch, M.P., Ragan, T., Akkin, T., Wedeen, V.J., Boas, D.A.  and Fischl, B. (2013). "Blockface histology with optical coherence tomography: A comparison with Nissl staining." Neuroimage 84C: 524-533. PMID: 24041872

Metelev, V., Zhang, S., Tabatadze, D., Kumar, A.T.  and Bogdanov, Jr., A. A. (2013). "The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores." Mol Biosyst 9(10): 2447-53. PMID: 23925269

Nizar, K., Uhlirova, H., Tian, P., Saisan, P.A., Cheng, Q., Reznichenko, L., Weldy, K.L., Steed, T.C., Sridhar, V.B., MacDonald, C.L., Cui, J., Gratiy, S.L., Sakadzic, S., Boas, D.A., Beka, T.I., Einevoll, G.T., Chen, J., Masliah, E., Dale, A.M., Silva, G.A. and Devor, A. (2013). "In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase." J Neurosci 33(19): 8411-8422. PMID: 23658179

Roche-Labarbe, N., Fenoglio, A., Radakrishnan, H., Kocienski-Filip, M., Carp, S.A., Dubb, J., Boas, D.A., Grant, P.E. and Franceschini, M.A. (2013). "Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates." Neuroimage. PMID: 23370052

Schytz, H.W., Barlose, M., Guo, S., Selb, J., Caparso, A., Jensen, R. and Ashina, M. (2013). "Experimental activation of the sphenopalatine ganglion provokes cluster-like attacks in humans." Cephalalgia. PMID: 23382519

Schytz, H.W., Jensen, B.E., Jennum, P., Selb, J., Boas, D.A. and Ashina, M. (2013). "Low-frequency oscillations and vasoreactivity of cortical vessels in obstructive sleep apnea during wakefulness: a near infrared spectroscopy study." Sleep Med 14(5): 416-421. PMID: 23517585

Yaseen, M.A., Sakadzic, S., Wu, W., Becker, W., Kasischke, K.A. and Boas, D.A. (2013). "In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH." Biomed Opt Express 4(2): 307-321. PMID: 23412419

M. A. Yucel, J. Selb, R. J. Cooper and D. A. Boas (2013). "Targeted Principle Component Analysis: A new motion artifact correction approach for near-infrared spectroscopy." Journal of Innovative Optical Health Sciences.


Bogdanov, A.A., Jr., Metelev, V., Zhang, S. and Kumar, A.T. (2012). "Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes." Mol Biosyst 8(8): 2166-2173. PMID: 22710322

Chen, J., Q. Fang and X. Intes (2012). "Mesh-based Monte Carlo method in time-domain widefield fluorescence molecular tomography." J Biomed Opt 17(10): 106009. PMID: 23224008

Cooper, R.J., Caffini, M., Dubb, J., Fang, Q., Custo, A., Tsuzuki, D., Fischl, B., Wells, W., 3rd, Dan, I. and Boas, D.A. (2012). "Validating atlas-guided DOT: A comparison of diffuse optical tomography informed by atlas and subject-specific anatomies." Neuroimage 62(3): 1999-2006. PMID: 22634215

Cooper, R.J., Gagnon, L., Goldenholz, D., Boas, D.A. and Greve, D.N. (2012). "The utility of near-infrared spectroscopy in the regression of low-frequency physiological noise from functional magnetic resonance imaging data." Neuroimage 59(4): 3128–3138. PMID: 22119653

Cooper, R.J., Selb, J., Gagnon, L., Phillip, D., Schytz, H.W., Iversen, H.K., Ashina, M. and Boas, D.A. (2012). "A systematic comparison of motion artifact correction techniques for functional near-infrared spectroscopy." Front Neurosci 6: 147. PMID: 23087603

Devor, A., S. Sakadzic, V. J. Srinivasan, M. A. Yaseen, K. Nizar, P. A. Saisan, P. Tian, A. M. Dale, S. A. Vinogradov, M. A. Franceschini and D. A. Boas (2012). "Frontiers in optical imaging of cerebral blood flow and metabolism." J Cereb Blood Flow Metab. PMID: 22252238

Esipova, T.V., Ye, X., Collins, J.E., Sakadzic, S., Mandeville, E.T., Murray, C.B. and Vinogradov, S.A. (2012). "Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources." Proc Natl Acad Sci U S A 109(51): 20826-20831. PMID: 23213211

Fang, Q. and D. R. Kaeli (2012). "Accelerating mesh-based Monte Carlo method on modern CPU architectures." Biomed Opt Express 3(12): 3223-3230. PMID: 23243572

Gagnon, L., Cooper, R.J., Yucel, M.A., Perdue, K.L., Greve, D.N. and Boas, D.A. (2012). "Short separation channel location impacts the performance of short channel regression in NIRS." Neuroimage 59: 2518–2528. (Supp. Fig. 1) (Supp. Fig. 2) (Supp. Fig. 3) PMID: 21945793

Gagnon, L., Yucel, M.A., Dehaes, M., Cooper, R.J., Perdue, K.L., Selb, J., Huppert, T.J., Hoge, R.D. and Boas, D.A. (2012). "Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements." Neuroimage 59: 3933-3940. PMID: 22036999

Goergen, C.J., Chen, H.H., Bogdanov, A., Sosnovik, D.E. and Kumar, A.T. (2012). "In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium." J Biomed Opt 17(5): 056001. PMID: 22612124

Guo, Y., Yuan, H., Rice, W.L., Kumar, A.T., Goergen, C.J., Jokivarsi, K. and Josephson, L. (2012). "The PEG-Fluorochrome Shielding Approach for Targeted Probe Design." J Am Chem Soc 134(47): 19338-19341. PMID: 23137147

Kumar, A.T. (2012). "Direct Monte Carlo computation of time-resolved fluorescence in heterogeneous turbid media." Opt Lett 37(22): 4783-4785. PMID: 23164912

Lee, J. and Boas, D.A. (2012). "Frequency-domain measurement of neuronal activity using dynamic optical coherence tomography." Conf Proc IEEE Eng Med Biol Soc 2012: 2643-2646. PMID: 23366468

Lee, J., Wu, W., Jiang, J.Y., Zhu, B. and Boas, D.A. (2012). "Dynamic light scattering optical coherence tomography." Optics Express 20(20): 22262-22277.

Moriggi, L., Yaseen, M.A., Helm, L. and Caravan, P. (2012). "Serum Albumin Targeted, pH-Dependent Magnetic Resonance Relaxation Agents." Chemistry 18(12): 3675-3686. PMID: 22328098

Perdue, K.L., Fang, Q. and Diamond, S.G. (2012). "Quantitative assessment of diffuse optical tomography sensitivity to the cerebral cortex using a whole-head probe." Phys Med Biol 57(10): 2857-2872. PMID: 22513789

Roche-Labarbe, N., Fenoglio, A., Aggarwal, A., Dehaes, M., Carp, S.A., Franceschini, M.A. and Grant, P.E. (2012). "Near-infrared spectroscopy assessment of cerebral oxygen metabolism in the developing premature brain." J Cereb Blood Flow Metab 32(3): 481-488. PMID: 22027937

Roche-Labarbe, N., Grant, P.E. and Franceschini, M.A. (2012). Assessment of Infant Brain Development. Handbook of Biophotonics. Vol.2: Photonics for Health Care. J. Popp, Tuchin, V.V., Chiou, A. and Heinemann, S. Weinheim, Germany, Wiley-VCH Verlag GmbH & Co. KGaA.

Srinivasan, V.J., Radhakrishnan, H., Jiang, J.Y., Barry, S. and Cable, A.E. (2012). "Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast." Opt Express 20(3): 2220-2239. PMID: 22330462

Srinivasan, V.J., Radhakrishnan, H., Lo, E.H., Mandeville, E.T., Jiang, J.Y., Barry, S. and Cable, A.E. (2012). "OCT methods for capillary velocimetry." Biomed Opt Express 3(3): 612-629. PMID: 22435106

Schytz, H.W., Hansen, J.M., Phillip, D., Selb, J., Boas, D.A. and Ashina, M. (2012). "Nitric Oxide Modulation of Low-Frequency Oscillations in Cortical Vessels in FHM - a NIRS Study." Headache. PMID: 22352839

Wilcox, T., Stubbs, J., Hirshkowitz, A. and Boas, D.A. (2012). "Functional activation of the infant cortex during object processing." Neuroimage 62(3): 1833-1840. PMID: 22634218

Yucel, M.A., Huppert, T.J., Boas, D.A. and Gagnon, L. (2012). "Calibrating the BOLD signal during a motor task using an extended fusion model incorporating DOT, BOLD and ASL data." Neuroimage 61(4): 1268-1276. PMID: 22546318

Zimmermann, B.B., Roche-Labarbe, N., Surova, A., Boas, D.A., Wolf, M., Grant, P.E. and Franceschini, M.A. (2012). "The confounding effect of systemic physiology on the hemodynamic response in newborns." Adv Exp Med Biol 737: 103-109. PMID: 22259089


Baraghis, E., Devor, A., Fang, Q., Srinivasan, V.J., Wu, W., Lesage, F., Ayata, C., Kasischke, K.A., Boas, D.A. and Sakadzic, S. (2011). "Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response." J Biomed Opt 16(10): 106003.

Boas, D.A. and Franceschini, M.A. (2011). "Haemoglobin oxygen saturation as a biomarker: the problem and a solution." Philos Transact A Math Phys Eng Sci 369(1955): 4407-4424. PMID: 22006898

Carp, S.A., Roche-Labarbe, N., Franceschini, M.A., Srinivasan, V.J., Sakadzic, S. and Boas, D.A. (2011). "Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels." Biomed Opt Express 2(7): 2047-2054. PMID: 21750779

Chen, H.C., Vaid, J., Boas, D.A. and Bortfeld, H. (2011). "Examining the phonological neighborhood density effect using near infrared spectroscopy." Hum Brain Mapp 32(9): 1363-1370. PMID: 20690126

Dehaes, M., Grant, P., Sliva, D., Roche-Labarbe, N., Pienaar, R., Boas, D., Franceschini, M. and Selb, J. (2011). "Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult." Biomed. Opt. Express 2(3): 552-567. (See also: Biomedical Optics Express website)

Devor, A., Sakadzic, S., Saisan, P.A., Yaseen, M.A., Roussakis, E., Srinivasan, V.J., Vinogradov, S.A., Rosen, B.R., Buxton, R.B., Dale, A.M. and Boas, D.A. (2011). ""Overshoot" of O2 Is Required to Maintain Baseline Tissue Oxygenation at Locations Distal to Blood Vessels." J Neurosci 31(38): 13676-13681.

Fang, Q. (2011). "Comment on "A study on tetrahedron-based inhomogeneous Monte-Carlo optical simulation"." Biomed Opt Express 2(5): 1258-1264. PMID: 21559136

Fang, Q., Selb, J., Carp, S.A., Boverman, G., Miller, E.L., Brooks, D.H., Moore, R.H., Kopans, D.B. and Boas, D.A. (2011). "Combined optical and X-ray tomosynthesis breast imaging." Radiology 258(1): 89-97. PMID: 21062924

Gagnon, L., Perdue, K., Greve, D.N., Goldenholz, D., Kaskhedikar, G. and Boas, D.A. (2011). "Improved recovery of the hemodynamic response in diffuse optical imaging using short optode separations and state-space modeling." Neuroimage 56(3): 1362-1371. PMID: 21385616

Kumar, A.T. (2011). "Fluorescence lifetime-based optical molecular imaging." Methods Mol Biol 680: 165-80. PMID: 21153381

Laxminarayan, S., Tadmor, G., Diamond, S.G., Miller, E., Franceschini, M.A. and Brooks, D.H. (2011). "Modeling habituation in rat EEG-evoked responses via a neural mass model with feedback." Biol Cybern 105(5-6): 371-397. PMID: 22282292

Lee, J., Boas, D.A. and Kim, S.J. (2011). "Multiphysics neuron model for cellular volume dynamics." IEEE Trans Biomed Eng 58(10): 3000-3003. PMID: 21659016

Lee, J., Srinivasan, V., Radhakrishnan, H. and Boas, D.A. (2011). "Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex." Opt Express 19(22): 21258-21270. PMID: 22108978

Mazhar, A., Cuccia, D.J., Rice, T.B., Carp, S.A., Durkin, A.J., Boas, D.A., Choi, B. and Tromberg, B.J. (2011). "Laser speckle imaging in the spatial frequency domain." Biomed Opt Express 2(6): 1553-1563.

Radhakrishnan, H., Wu, W., Boas, D. and Franceschini, M.A. (2011). "Study of neurovascular coupling by modulating neuronal activity with GABA." Brain Res 1372: 1-12. PMID: 21145313

Sakadzic, S., Roussakis, E., Yaseen, M.A., Mandeville, E.T., Srinivasan, V.J., Arai, K., Ruvinskaya, S., Wu, W., Devor, A., Lo, E.H., Vinogradov, S.A. and Boas, D.A. (2011). "Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence." J Vis Exp(51): e1694. (JoVE Website)

Srinivasan, V.J., Atochin, D.N., Radhakrishnan, H., Jiang, J.Y., Ruvinskaya, S., Wu, W., Barry, S., Cable, A.E., Ayata, C., Huang, P.L. and Boas, D.A.(2011). "Optical coherence tomography for the quantitative study of cerebrovascular physiology." J Cereb Blood Flow Metab 31(6): 1339-1345. PMID: 21364599 (Supp Figures) (Supp Methods) (Feature Article Commentary)

Tian, P., Devor, A., Sakadžic,́ S., Dale, A.M. and Boas, D.A. (2011). "Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain." J Biomed Opt 16(1): 016006. PMID: 21280912

Yaseen, M.A., Srinivasan, V.J., Sakadžić, S., Radhakrishnan, H., Gorczynska, I., Wu, W., Fujimoto, J.G. and Boas, D.A. (2011). "Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation." J Cereb Blood Flow Metab 31(4): 1051-63. PMID: 21179069

Yuzawa, I., Sakadzic, S., Srinivasan, V.J., Shin, H.K., Eikermann-Haerter, K., Boas, D.A. and Ayata, C. (2011). "Cortical spreading depression impairs oxygen delivery and metabolism in mice." J Cereb Blood Flow Metab. PMID: 22008729


Boas, D.A. and Dunn, A.K. (2010). "Laser speckle contrast imaging in biomedical optics." J Biomed Opt 15(1): 011109. PMID: 20210435

Carp, S.A., Dai, G.P., Boas, D.A., Franceschini, M.A. and Kim , Y.R. (2010). "Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring." Biomed Opt Exp 1(2): 553-565. (Biomedical Optics Express web page) PMID: 21258489

Custo, A., Boas, D.A., Tsuzuki, D., Dan, I., Mesquita, R., Fischl, B., Grimson, W.E. and Wells, W., 3rd (2010). "Anatomical atlas-guided diffuse optical tomography of brain activation." Neuroimage 49(1): 561-567. PMID: 19643185

Fang, Q. (2010). "Mesh-based Monte Carlo method using fast ray-tracing in Plücker coordinates." Biomed Opt Exp 1(1): 165-175. (Biomedical Optics Express web page) PMID: 21170299

Fang, Q., Moore, R.H., Kopans, D.B. and Boas, D.A. (2010). "Compositional-prior-guided Image Reconstruction Algorithm for Multi-modality Imaging." Biomed Opt Exp 1(1): 223-235. (Biomedical Optics Express web page) PMID: 21258460

Franceschini, M.A., Radhakrishnan, H., Thakur, K., Wu, W., Ruvinskaya, S., Carp, S. and Boas, D.A. (2010). "The effect of different anesthetics on neurovascular coupling." Neuroimage 51(4): 1367-1377. PMID: 20350606

Hyde, D.C., Boas, D.A., Blair, C. and Carey, S. (2010). "Near-infrared spectroscopy shows right parietal specialization for number in pre-verbal infants." Neuroimage 53(2): 647-652. PMID: 20561591

Mesquita, R.C., Franceschini, M.A. and Boas, D.A. (2010). "Resting state functional connectivity of the whole head with near-infrared spectroscopy." Biomed Opt Exp 1(1): 324-336. (Biomedical Optics Express web page) PMID: 21258470

Raymond, S.B., Boas, D.A., Backsai, B.J. and Kumar, A.T.N. (2010). "Lifetime-based tomographic multiplexing." J Biomed Opt 15(4): 046011.PMID: 20799813

Roche-Labarbe, N., Carp, S.A., Surova, A., Patel, M., Boas, D.A., Grant, P.E. and Franceschini, M.A. (2010). "Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life." Hum Brain Mapp 31(3): 341-352. PMID: 19650140 (ERRATUM)

Sakadzic, S., Roussakis, E., Yaseen, M.A., Mandeville, E.T., Srinivasan, V.J., Arai, K., Ruvinskaya, S., Devor, A., Lo, E.H., Vinogradov, S.A. and Boas, D.A. (2010). "Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue." Nat Methods 7(9):755-759. PMID: 20693997 (Supplementary Figures) (written up in the News and Views section of the same issue. See: Dirnagl, U. "Oxygen maps in the brain." Nat Methods 7(9):697-699.)

Schytz, H.W., Hansson, A., Phillip, D., Selb, J., Boas, D.A., Iversen, H.K. and Ashina, M. (2010). "Spontaneous low-frequency oscillations in cerebral vessels: applications in carotid artery disease and ischemic stroke." J Stroke Cerebrovasc Dis. 19(6):465-74. PMID: 20864356

Srinivasan, V.J., Jiang, J.Y., Yaseen, M.A., Radhakrishnan, H., Wu, W., Barry, S., Cable, A.E. and Boas, D.A. (2010). "Rapid volumetric angiography of cortical microvasculature with optical coherence tomography." Opt Lett 35(1): 43-45. PMID: 20664667

Srinivasan, V.J., Sakadzic, S., Gorczynska, I., Ruvinskaya, S., Wu, W., Fujimoto, J.G. and Boas, D.A. (2010). "Quantitative cerebral blood flow with Optical Coherence Tomography." Opt Express 18(3): 2477-2494. PMID: 20174075 (Written up in Nature Photonics Research Highlights)

Sukhotinsky, I., Yaseen, M.A., Sakadzic, S., Ruvinskaya, S., Sims, J.R., Boas, D.A., Moskowitz, M.A. and Ayata, C. (2010). "Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range." J Cereb Blood Flow Metab 30(6): 1168-1177. PMID: 20087371

Tian, P., Teng, I.C., May, L.D., Kurz, R., Lu, K., Scadeng, M., Hillman, E.M., De Crespigny, A.J., D'Arceuil, H.E., Mandeville, J.B., Marota, J.J., Rosen, B.R., Liu, T.T., Boas, D.A., Buxton, R.B., Dale, A.M. and Devor, A. (2010). "Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal." Proc Natl Acad Sci U S A. 107(34):15246-51. PMID: 20696904

Wilcox, T., Haslup, J.A. and Boas, D.A. (2010). "Dissociation of processing of featural and spatiotemporal information in the infant cortex." Neuroimage. 53(4):1256-63. PMID: 20603218


Becerra, L., Harris, W., Grant, M., George, E., Boas, D. and Borsook, D. (2009). "Diffuse optical tomography activation in the somatosensory cortex: specific activation by painful vs. non-painful thermal stimuli." PLoS One 4(11): e8016. PMID: 19956637

Boas, D. and Franceschini, M.A. (2009). "Near-infrared imaging." Scholarpedia 4(4): 6997.

Boas, D. A. and Payne, S. J. (2009). "Comment on ‘Estimating a modified Grubb’s exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler’." Physiol Meas 30: L9-L11. (The letter is also available on the IOP website) PMID: 19767672

Bortfeld, H., Fava, E. and Boas, D.A. (2009). "Identifying cortical lateralization of speech processing in infants using near-infrared spectroscopy." Dev Neuropsychol 34(1): 52-65. PMID: 19142766

Chen, Y., Aguirre, A.D., Ruvinskaya, L., Devor, A., Boas, D.A. and Fujimoto, J.G. (2009). "Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation." J Neurosci Methods 178(1): 162-73. PMID: 19121336

Diamond, S. G., Perdue, K. L. and Boas, D. A. (2009). "A cerebrovascular response model for functional neuroimaging including dynamic cerebral autoregulation." Math Biosci 220(2): 102-117. PMID: 19442671

Fang, Q. and Boas, D. A. (2009). "Monte Carlo Simulation of Photon Migration in 3D Turbid Media Accelerated by Graphics Processing Units." Opt Express 17(22): 20178-20190. PMID: 19997242

Fang, Q., Carp, S.A., Selb, J., Boverman, G., Zhang, Q., Kopans, D.B., Moore, R.H., Miller, E.L., Brooks, D.H. and Boas, D.A. (2009). "Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression." IEEE Trans Med Imaging 28(1): 30-42. PMID: 19116186

Grant, P. E., Roche-Labarbe, N., Surova, A., Themelis, G., Selb, J., Warren, E. K., Krishnamoorthy, K. S., Boas, D. A. and Franceschini, M. A. (2009). "Increased cerebral blood volume and oxygen consumption in neonatal brain injury." J Cereb Blood Flow Metab 29(10): 1704-1713. PMID: 19675563

Huppert, T.J., Allen, M.S., Diamond, S.G. and Boas, D.A. (2009). "Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model." Hum Brain Mapp 30(5): 1548-67. PMID: 18649348

Huppert, T.J., Diamond, S.G., Franceschini, M.A. and Boas, D.A. (2009). "HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain." Appl Opt 48(10): D280-98. PMID: 19340120 (Selected for publication in the Virtual Journal for Biomedical Optics)

Huppert, T. J., Jones, P. B., Devor, A., Dunn, A. K., Teng, I. C., Dale, A. M. and Boas, D. A. (2009). "Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia." J Biomed Opt 14(4): 044038. PMID: 19725749

Keller, C.J., Cash, S.S., Narayanan, S., Wang, C., Kuzniecky, R., Carlson, C., Devinsky, O., Thesen, T., Doyle, W., Sassaroli, A., Boas, D.A., Ulbert, I. and Halgren, E. (2009). "Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex." J Neurosci Methods 179: 208-218. PMID: 19428529

Lebedev, A.Y., Cheprakov, A.V., Sakadzic, S., Boas, D.A., Wilson, D.F. and Vinogradov, S.A. (2009). "Dendritic phosphorescent probes for oxygen imaging in biological systems." ACS Appl Mater Interfaces 1(6): 1292-1304. PMID: 20072726

Kumar, A.T., Chung, E., Raymond, S.B., van de Water, J.A., Shah, K., Fukumura, D., Jain, R.K., Bacskai, B.J. and Boas, D.A. (2009). "Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast." Opt Lett 34(13): 2066-2068. PMID: 19572001

Mesquita, R.C., Huppert, T.J. and Boas, D.A. (2009). "Exploring neuro-vascular and neuro-metabolic coupling in rat somatosensory cortex." Phys Med Biol 54(2): 175-85. PMID: 19088392

Muehlschlegel, S., Selb, J., Patel, M., Diamond, S.G., Franceschini, M.A., Sorensen, A.G., Boas, D.A. and Schwamm, L.H. (2009). "Feasibility of NIRS in the neurointensive care unit: a pilot study in stroke using physiological oscillations." Neurocrit Care 11(2): 288-295. PMID: 19649749

Ou, W., Nissila, I., Radhakrishnan, H., Boas, D.A., Hamalainen, M.S. and Franceschini, M.A. (2009). "Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition." Neuroimage 46(3): 624–632. PMID: 19286463

Payne, S. J., Selb, J. and Boas, D. A. (2009). "Effects of autoregulation and CO2 reactivity on cerebral oxygen transport." Ann Biomed Eng 37(11): 2288-2298. PMID: 19629692

Radhakrishnan, H., Vanduffel, W., Deng, H.P., Ekstrom, L., Boas, D.A. and Franceschini, M.A. (2009). "Fast optical signal not detected in awake behaving monkeys." Neuroimage 45(2): 410-419. PMID: 19150500

Raymond, S. B., Kumar, A. T., Boas, D. A. and Bacskai, B. J. (2009). "Optimal parameters for near infrared fluorescence imaging of amyloid plaques in Alzheimer's disease mouse models." Phys Med Biol 54(20): 6201-6216. PMID: 19794239

Sakadžić, S., Yuan, S., Dilekoz, E., Ruvinskaya, S., Vinogradov, S.A., Ayata, C. and Boas, D.A. (2009). "Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression." Appl Opt 48(10): D169-D177. PMID: 19340106

Schytz, H.W., Wienecke, T., Jensen, L.T., Selb, J., Boas, D.A. and Ashina, M. (2009). "Changes in cerebral blood flow after acetazolamide: an experimental study comparing near-infrared spectroscopy and SPECT." Eur J Neurol 16(4): 461-467. PMID: 19236469

Srinivasan, V. J., Sakadzic, S., Gorczynska, I., Ruvinskaya, S., Wu, W., Fujimoto, J. G. and Boas, D. A. (2009). "Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography." Opt Lett 34(20): 3086-3088. PMID: 19838234

Wilcox, T., Bortfeld, H., Woods, R., Wruck, E., Armstrong, J. and Boas, D. (2009). "Hemodynamic changes in the infant cortex during the processing of featural and spatiotemporal information." Neuropsychologia 47: 657-662. PMID: 19071143

Yaseen, M. A., Srinivasan, V. J., Sakadzic, S., Wu, W., Ruvinskaya, S., Vinogradov, S. A. and Boas, D. A. (2009). "Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy." Opt Express 17(25): 22341-22350. PMID: 20052157

Yucel, M.A., Devor, A., Akin, A. and Boas, D.A. (2009). "The Possible Role of CO(2) in Producing A Post-Stimulus CBF and BOLD Undershoot." Front Neuroenergetics 1: 7. PMID: 20027233


Becerra, L., Harris, W., Joseph, D., Huppert, T., Boas, D.A. and Borsook, D. (2008). "Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems." Neuroimage 41: 252-259. PMID: 18394924

Boas, D.A., Jones, S.R., Devor, A., Huppert, T.J. and Dale, A.M. (2008). "A vascular anatomical network model of the spatio-temporal response to brain activation." Neuroimage 40(3): 1116-29. PMID: 18289880

Boverman, G., Miller, E.L., Brooks, D.H., Isaacson, D., Fang, Q. and Boas, D.A. (2008). "Estimation and statistical bounds for three-dimensional polar shapes in diffuse optical tomography." IEEE Trans Med Imaging 27(6): 752-65. PMID: 18541483

Carp, S.A., Selb, J., Fang, Q., Moore, R., Kopans, D.B., Rafferty, E. and Boas, D.A. (2008). "Dynamic functional and mechanical response of breast tissue to compression." Opt Express 16(20): 16064-78. PMID: 18825246

Chen, H.C., Vaid, J., Bortfeld, H. and Boas, D.A. (2008). "Optical imaging of phonological processing in two distinct orthographies." Exp Brain Res 184(3): 427-33. PMID: 17999056

Devor, A., Hillman, E.M., Tian, P., Waeber, C., Teng, I.C., Ruvinskaya, L., Shalinsky, M.H., Zhu, H., Haslinger, R.H., Narayanan, S.N., Ulbert, I., Dunn, A.K., Lo, E.H., Rosen, B.R., Dale, A.M., Kleinfeld, D. and Boas, D.A. (2008). "Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex." J Neurosci 28(53): 14347-57. PMID: 19118167
Supplemental Material | Fig. 1 | Fig. 2 | Fig. 3

Fang, Q., Sakadzic, S., Ruvinskaya, L., Devor, A., Dale, A.M. and Boas, D.A. (2008). "Oxygen advection and diffusion in a three- dimensional vascular anatomical network." Opt Express 16(22): 17530-41. PMID: 18958033

Franceschini, M.A., Nissila, I., Wu, W., Diamond, S.G., Bonmassar, G. and Boas, D.A. (2008). "Coupling between somatosensory evoked potentials and hemodynamic response in the rat." Neuroimage(41): 189-203. PMID: 18420425

Gagnon, L., Gauthier, C., Hoge, R.D., Lesage, F., Selb, J. and Boas, D.A. (2008). "Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system." J Biomed Opt 13(5): 054019. PMID: 19021399

Huppert, T.J., Diamond, S.G. and Boas, D.A. (2008). "Direct estimation of evoked hemoglobin changes by multimodality fusion imaging." J Biomed Opt 13(5): 054031. PMID: 19021411

Jones, P.B., Shin, H.K., Boas, D.A., Hyman, B.T., Moskowitz, M.A., Ayata, C. and Dunn, A.K. (2008). "Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia." Journal Biomed Optics 13(4): 044007-11. PMID: 19021335

Kumar, A., Raymond, S., Bacskai, B. and Boas, D. (2008). "Comparison of Frequency Domain and Time Domain Fluorescence Lifetime Tomography." Opt Lett 33(5): 470-472. PMID: 18311295

Kumar, A.T., Raymond, S.B., Dunn, A.K., Bacskai, B.J. and Boas, D.A. (2008). "A time domain fluorescence tomography system for small animal imaging." IEEE Trans Med Imaging 27(8): 1152-63. PMID: 18672432

Sakadžić, S., Demirbas, U., Mempel, T.R., Moore, A., Ruvinskaya, S., Boas, D.A., Sennaroglu, A., Kartner, F.X. and Fujimoto, J.G. (2008). "Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser." Opt Express 16(25): 20848-20863. PMID: 19065223

Shin, H.K., Nishimura, M., Jones, P.B., Ay, H., Boas, D.A., Moskowitz, M.A. and Ayata, C. (2008). "Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia." Stroke 39(5): 1548-55. PMID: 18340095

Wilcox, T., Bortfeld, H., Woods, R., Wruck, E. and Boas, D.A. (2008). "Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration." Dev Sci 11(3): 361-70. PMID: 18466370


Bortfeld, H., Wruck, E. and Boas, D. A. (2007). "Assessing infants' cortical response to speech using near-infrared spectroscopy." Neuroimage 34(1): 407-15. PMID: 17045812

Boverman, G., Fang, Q., Carp, S.A., Miller, E.L., Brooks, D.H., Selb, J., Moore, R.H., Kopans, D.B. and Boas, D.A. (2007). "Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography." Phys Med Biol 52(12): 3619-41. PMID: 17664563

Devor, A., Tian, P., Nishimura, N., Teng, I. C., Hillman, E. M. C., Narayanan, S. N., Ulbert, I., Boas, D. A., Kleinfeld, D. and Dale, A. M. (2007). "Suppressed Neuronal Activity and Concurrent Arteriolar Vasoconstriction May Explain Negative Blood Oxygenation Level-Dependent Signal." The Journal of Neuroscience 27(16): 4452– 4459.

Franceschini, M.A., Thaker, S., Themelis, G., Krishnamoorthy, K.K., Bortfeld, H., Diamond, S.G., Boas, D.A., Arvin, K. and Grant, P.E. (2007). "Assessment of infant brain development with frequency-domain near-infrared spectroscopy." Pediatr Res 61(5 Pt 1): 546-51. PMID: 17413855

Hillman, E. M., Devor, A., Bouchard, M. B., Dunn, A. K., Krauss, G. W., Skoch, J., Bacskai, B. J., Dale, A. M. and Boas, D. A. (2007). "Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation." Neuroimage 35(1): 89-104. PMID: 17222567 See also: Supplemental Material.

Huppert, T. J., Allen, M. S., Benav, H., Jones, P. B. and Boas, D. A. (2007). "A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation." J Cereb Blood Flow Metab 27: 1262–1279. PMID: 17200678

Ma, G., Delorme, J. F., Gallant, P. and Boas, D. A. (2007). "Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties." Appl Opt 46(10): 1686-92. PMID: 17356611

Schweiger, M., Nissila, I., Boas, D. A. and Arridge, S. R. (2007). "Image reconstruction in optical tomography in the presence of coupling errors." Appl Opt 46(14): 2743-56. PMID: 17446924

Selb, J., Dale, A.M. and Boas, D.A. (2007). "Linear 3D reconstruction of time-domain diffuse optical imaging differential data: improved depth localization and lateral resolution." Opt Express 15(25): 16400-16412. PMID: 19550930

Shin, H.K., Salomone, S., Potts, E.M., Lee, S.W., Millican, E., Noma, K., Huang, P.L., Boas, D.A., Liao, J.K., Moskowitz, M.A. and Ayata, C. (2007). "Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms." J Cereb Blood Flow Metab 27(5): 998-1009. PMID: 17033691

Shin, H.K., Dunn, A.K., Jones, P.B., Boas, D.A., Lo, E.H., Moskowitz, M.A. and Ayata, C. (2007). "Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia." Brain 130(Pt 6): 1631-42. PMID: 17468117

Themelis, G., D'Arceuil, H., Diamond, S. G., Thaker, S., Huppert, T. J., Boas, D. A. and Franceschini, M. A. (2007). "Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations." J Biomed Opt 12(1): 014033. PMID: 17343508


Aguirre, A. D., Chen, Y., Fujimoto, J. G., Ruvinskaya, L., Devor, A. and Boas, D. A. (2006). "Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography." Opt Lett 31(23): 3459-61. PMID: 17099749

Carp, S. A., Kauffman, T., Fang, Q., Rafferty, E., Moore, R., Kopans, D. and Boas, D. (2006). "Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements." Journal Biomed Optics 11(6): 064016.

Custo, A., Wells III, W. M., Barnett, A. H., Hillman, E. M. and Boas, D. A. (2006). "Effective scattering coefficient of the cerebral spinal fluid in adult head models for diffuse optical imaging." Appl Opt 45(19): 4747-55. PMID: 16799690

Diamond, S. G., Huppert, T. J., Kolehmainen, V., Franceschini, M. A., Kaipio, J. P., Arridge, S. R. and Boas, D. A. (2006). "Dynamic physiological modeling for functional diffuse optical tomography." Neuroimage 30(1): 88-101. PMID: 16242967

Franceschini, M. A., Joseph, D. K., Huppert, T. J., Diamond, S. G. and Boas, D. A. (2006). "Diffuse optical imaging of the whole head." Journal Biomed Optics 11(5): 054007. PMID: 17092156

Huppert, T. J., Hoge, R. D., Dale, A. M., Franceschini, M. A. and Boas, D. A. (2006). "Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging." Journal Biomed Optics 11(6): 064018. PMID: 17212541

Huppert, T. J., Hoge, R. D., Diamond, S. G., Franceschini, M. A. and Boas, D. A. (2006). "A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans." Neuroimage 29(2): 368-82. PMID: 16303317

Joseph, D. K., Huppert, T. J., Franceschini, M. A. and Boas, D. A. (2006). "Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging." Appl Opt 45(31): 8142-51. PMID: 17068557

Kumar, A. T. N., Raymond, S. B., Boverman, G., Boas, D. A. and Bacskai, B. J. (2006). "Time resolved fluorescence tomography of turbid media based on lifetime contrast." Opt Express 14(25): 12255. PMID: 19529654

Selb, J., Joseph, D. K. and Boas, D. A. (2006). "Time-gated optical system for depth-resolved functional brain imaging." Journal Biomed Optics 11(4): 044008. PMID: 16965165

Shin, H. K., Dunn, A. K., Jones, P. B., Boas, D. A., Moskowitz, M. A. and Ayata, C. (2006). "Vasoconstrictive neurovascular coupling during focal ischemic depolarizations." J Cereb Blood Flow Metab 26(8): 1018-30. PMID: 16340958


Boas, D.A. and Dale, A.M. (2005). Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function. Appl Opt, 44(10), 1957-1968. PMID: 15813532

Boas, D.A. and Frostig, R.D. (2005). Optics in Neuroscience (Special Guest Editorial). Journal of Biomedical Optics, 10(1), 011001.

Boverman, G., Miller, E.L., Li, A., Zhang, Q., Chaves, T., Brooks, D.H. and Boas, D.A. (2005). Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information. Phys Med Biol, 50(17), 3941-3956. PMID: 16177522

Culver, J.P., Siegel, A.M., Franceschini, M.A., Mandeville, J.B. and Boas, D.A. (2005). Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin. Neuroimage, 27(4), 947-959. PMID: 16084112

D'Arceuil, H.E., Hotakainen, M.P., Liu, C., Themelis, G., de Crespigny, A.J. and Franceschini, M.A. (2005). Near-infrared frequency-domain optical spectroscopy and magnetic resonance imaging: a combined approach to studying cerebral maturation in neonatal rabbits. J Biomed Opt, 10(1), 11011. PMID: 15847577

Devor, A., Ulbert, I., Dunn, A.K., Narayanan, S.N., Jones, S.R., Andermann, M.L., Boas, D.A. and Dale, A.M. (2005). Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity. Proc Natl Acad Sci U S A, 102(10), 3822-3827. PMID: 15734797 (Supporting Information)

Diamond, S.G., Huppert, T.J., Kolehmainen, V., Franceschini, M.A., Kaipio, J.P., Arridge, S.R. and Boas, D.A. (2005). "Physiological system identification with the Kalman filter in diffuse optical tomography." Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 8(Pt 2): 649-656. PMID: 16686015

Dunn, A.K., Devor, A., Dale, A.M. and Boas, D.A. (2005). Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex. Neuroimage, 27(2), 279-290. PMID: 15925522

Hoge, R.D., Franceschini, M.A., Covolan, R.J., Huppert, T., Mandeville, J.B. and Boas, D.A. (2005). Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow using diffuse optical imaging and arterial spin-labeling MRI. Neuroimage, 25(3), 701-707. PMID: 15808971

Jones, P.B., Shin, H.K., Dunn, A.K., Hyman, B.T., Boas, D.A., Moskowitz, M.A. and Ayata, C. (2005). Multimodal optical imaging of mouse Ischemic cortex. In M. Analoui & D.A. Dunn (Eds.), Optical Methods in Drug Discovery and Development (pp. 60090X): SPIE.

Kumar, A.T., Skoch, J., Bacskai, B.J., Boas, D.A. and Dunn, A.K. (2005). Fluorescence-lifetime-based tomography for turbid media. Opt Lett, 30(24), 3347-3349. PMID: 16389827 (also selected for the January 1, 2006 issue of the Virtual Journal of Biological Physics Research)

Li, A., Boverman, G., Zhang, Y., Brooks, D., Miller, E.L., Kilmer, M.E., Zhang, Q., Hillman, E.M. and Boas, D.A. (2005). Optimal linear inverse solution with multiple priors in diffuse optical tomography. Appl Opt, 44(10), 1948-1956. PMID: 15813531

Nioka, S., Izzetoglu, M., Mawn, T., Nijland, M.J., Boas, D. and Chance, B. (2005). Fetal transabdominal pulse oximeter studies using a hypoxic sheep model. J Matern Fetal Neonatal Med, 17(6), 393-399. PMID: 16009642

Selb, J., Stott, J.J., Franceschini, M.A., Sorensen, A.G. and Boas, D.A. (2005). Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation. J Biomed Opt, 10(1), 11013. PMID: 15847579

Skoch, J., Dunn, A., Hyman, B.T. and Bacskai, B.J. (2005). Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. J Biomed Opt, 10(1), 11007. PMID: 15847573

Wilcox, T., Bortfeld, H., Woods, R., Wruck, E. and Boas, D.A. (2005). Using near-infrared spectroscopy to assess neural activation during object processing in infants. J Biomed Opt, 10(1), 11010. PMID: 15847576

Yuan, S., Devor, A., Boas, D.A. and Dunn, A.K. (2005). Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging. Appl Opt, 44(10), 1823-1830. PMID: 15813518

Zhang, Q., Brukilacchio, T.J., Li, A., Stott, J.J., Chaves, T., Hillman, E., Wu, T., Chorlton, M., Rafferty, E., Moore, R.H., Kopans, D.B. and Boas, D.A. (2005). Coregistered tomographic x-ray and optical breast imaging: initial results. J Biomed Opt, 10(2), 024033. PMID: 15910106

Zhang, Y., Brooks, D.H. and Boas, D.A. (2005). A haemodynamic response function model in spatio-temporal diffuse optical tomography. Phys Med Biol, 50(19), 4625-4644. PMID: 16177494

Zhang, Y., Brooks, D.H., Franceschini, M.A. and Boas, D.A. (2005). Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imaging. J Biomed Opt, 10(1), 011014. PMID: 15847580


Ayata, C., Dunn, A.K., Gursoy, O.Y., Huang, Z., Boas, D.A. and Moskowitz, M.A. (2004). Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex. J Cereb Blood Flow Metab, 24(7), 744-755. PMID: 15241182

Ayata, C., Shin, H.K., Salomone, S., Ozdemir-Gursoy, Y., Boas, D.A., Dunn, A.K. and Moskowitz, M.A. (2004). Pronounced hypoperfusion during spreading depression in mouse cortex. J Cereb Blood Flow Metab, 24(10), 1172-1182. PMID: 15529018

Boas, D.A., Dale, A.M. and Franceschini, M.A. (2004). Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy. Neuroimage, 23 Suppl 1, S275-288. PMID: 15501097

Boas, D.A., Chen, K., Grebert, D. and Franceschini, M.A. (2004). Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans. Opt Lett, 29(13), 1506-1508. PMID: 15259728

Franceschini, M.A. and Boas, D.A. (2004). Noninvasive measurement of neuronal activity with near-infrared optical imaging. Neuroimage, 21(1), 372-386. PMID: 14741675

Hillman, E.M., Boas, D.A., Dale, A.M. and Dunn, A.K. (2004). Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media. Opt Lett, 29(14), 1650-1652. PMID: 15309848

Li, A., Zhang, Q., Culver, J.P., Miller, E.L. and Boas, D.A. (2004). Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography. Opt Lett, 29(3), 256-258. PMID: 14759043

Milstein, A.B., Stott, J.J., Oh, S., Boas, D.A., Millane, R.P., Bouman, C.A. and Webb, K.J. (2004). Fluorescence optical diffusion tomography using multiple-frequency data. J Opt Soc Am A Opt Image Sci Vis, 21(6), 1035-1049. PMID: 15191186

Quaresima, V., Ferrari, M., Franceschini, M.A., Hoimes, M.L. and Fantini, S. (2004). Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopy. J Biomed Opt, 9(2), 413-420. PMID: 15065910


Barnett, A.H., Culver, J.P., Sorensen, A.G., Dale, A. and Boas, D.A. (2003). Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging. Appl Opt, 42(16), 3095-3108. PMID: 12790461

Boas, D.A., Strangman, G., Culver, J.P., Hoge, R.D., Jasdzewski, G., Poldrack, R.A., Rosen, B.R. and Mandeville, J.B. (2003). Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy? Phys Med Biol, 48(15), 2405-2418. PMID: 12953906

Culver, J.P., Siegel, A.M., Stott, J.J. and Boas, D.A. (2003). Volumetric diffuse optical tomography of brain activity. Opt Lett, 28(21), 2061-2063. PMID: 14587815

Devor, A., Dunn, A.K., Andermann, M.L., Ulbert, I., Boas, D.A. and Dale, A.M. (2003). Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex. Neuron, 39(2), 353-359. PMID: 12873390

Dunn, A.K., Devor, A., Bolay, H., Andermann, M.L., Moskowitz, M.A., Dale, A.M. and Boas, D.A. (2003). Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation. Opt Lett, 28(1), 28-30. PMID: 12656525

Fabbri, F., Franceschini, M.A. and Fantini, S. (2003). Characterization of spatial and temporal variations in the optical properties of tissuelike media with diffuse reflectance imaging. Appl Opt, 42(16), 3063-3072. PMID: 12790458

Fabbri, F., Henry, M.E., Renshaw, P.F., Nadgir, S., Ehrenberg, B.L., Franceschini, M.A. and Fantini, S. (2003). Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapy. Brain Res, 992(2), 193-204. PMID: 14625058

Franceschini, M.A., Fantini, S., Thompson, J.H., Culver, J.P. and Boas, D.A. (2003). Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging. Psychophysiology, 40(4), 548-560. PMID: 14570163

Hebden, J.C., Boas, D.A., George, J.S. and Durkin, A.J. (2003). Topics in Biomedical Optics: Introduction. Appl Opt, 42(16), 2869-2870.

Jasdzewski, G., Strangman, G., Wagner, J., Kwong, K.K., Poldrack, R.A. and Boas, D.A. (2003). Differences in the hemodynamic response to event-related motor and visual paradigms as measured by near-infrared spectroscopy. Neuroimage, 20(1), 479-488. PMID: 14527608

Kilmer, M.E., Miller, E.L., Barbaro, A. and Boas, D. (2003). Three-dimensional shape-based imaging of absorption perturbation for diffuse optical tomography. Appl Opt, 42(16), 3129-3144. PMID: 12790464

Li, A., Miller, E.L., Kilmer, M.E., Brukilacchio, T.J., Chaves, T., Stott, J., Zhang, Q., Wu, T., Chorlton, M., Moore, R.H., Kopans, D.B. and Boas, D.A. (2003). Tomographic optical breast imaging guided by three-dimensional mammography. Appl Opt, 42(25), 5181-5190. PMID: 12962399

Milstein, A.B., Oh, S., Webb, K.J., Bouman, C.A., Zhang, Q., Boas, D.A. and Millane, R.P. (2003). Fluorescence optical diffusion tomography. Appl Opt, 42(16), 3081-3094. PMID: 12790460

Prince, S., Kolehmainen, V., Kaipio, J.P., Franceschini, M.A., Boas, D. and Arridge, S.R. (2003). Time-series estimation of biological factors in optical diffusion tomography. Phys Med Biol, 48(11), 1491-1504. PMID: 12817933

Siegel, A.M., Culver, J.P., Mandeville, J.B. and Boas, D.A. (2003). Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation. Phys Med Biol, 48(10), 1391-1403. PMID: 12812454

Stott, J.J., Culver, J.P., Arridge, S.R. and Boas, D.A. (2003). Optode positional calibration in diffuse optical tomography. Appl Opt, 42(16), 3154-3162. PMID: 12790466

Strangman, G., Franceschini, M.A. and Boas, D.A. (2003). Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters. Neuroimage, 18(4), 865-879. PMID: 12725763

Yodh, A.G. and Boas, D.A. (2003). Functional Imaging With Diffuse Light. In T. Vo-Dinh (Ed.), Biomedical Photonics (pp. 21-21 - 21-45). Boca Raton: CRC Press. (Part 1 Part 2 Part 3 Part 4)


Baird, AA, Kagen, J, Gaudette, T, Walz, KA, Hershlag, N, and Boas, DA. "Frontal Lobe Activation during Object Permanence: Data from Near-Infrared Spectroscopy." NeuroImage 16: 1120-1126. 2002. PMID: 12202098

Boas, DA, Franceschini, MA, Dunn, AK, and Strangman, G. "Noninvasive Imaging of Cerebral Activation with Diffuse Optical Tomography." In Vivo Optical Imaging of Brain Function. Ed. R.D. Frostig. Boca Raton: CRC Press. 2002. 193-221.

Boas DA, Culver JP, Stott JJ, and Dunn AK. "Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head" Opt. Express 10: 159-170 (2002).

Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, and Moskowitz MA. "Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model." Nat Med. 8(2):136-42. (2002). From CSD to Headache: a long and winding road -- A Commentary" PMID: 11821897

Franceschini MA, Boas DA, Zourabian A, Diamond SG, Nadgir S, Lin DW, Moore JB, and Fantini S. Near-infrared spiroximetry: Non-invasive measurements of venous saturation in piglets and human subjects. J Appl Physiol. 92, 372-384 (2002). PMID: 11744680

Strangman, G, Boas, DA and Sutton, JP. "Non-invasive Neuroimaging Using Near-Infrared Light." Biol Psychiatry. 52: 679-693. 2002 PMID: 12372658

Strangman, G, Culver, JP, Thompson, JH, and Boas, DA. "A Quantitative Comparison of Simultaneous BOLD fMRI and NIRS Recordings during Functional Brain Activation." NeuroImage 17: 719-731. 2002. PMID: 12377147


Boas DA, Brooks DH, Miller EL, DiMarzio CA, Kilmer M, Gaudette RJ and Zhang Q. "Imaging the body with diffuse optical tomography." IEEE Signal Processing Magazine 18(6): 57-75 (2001). (Part 1 | Part 2 | Part 3 | Part 4)

Boas DA, Gaudette TJ, Strangman G, Cheng X, Marota JJA and Mandeville JB.. "The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics." NeuroImage 13:76-90 (2001). PMID: 11133311

Boas DA, Gaudette TJ and Arridge SR. "Simultaneous imaging and optode calibration with diffuse optical tomography." Opt. Express 8:263-270 (2001).

Dunn AK, Bolay H, Moskowitz MA and Boas DA. "Dynamic imaging of cerebral blood flow using laser speckle." Journal of Cerebral Blood Flow and Metabolism 21:195-201 (2001). PMID: 11295873

Hayakawa CK, Spanier J, Bevilacqua F, Dunn AK, You JS, Tromberg BJ and Venugopalan V. "Perturbation Monte Carlo methods to solve inverse photon migration problems in heterogeneous tissues." Optics Letters 26(17): 1335-1337 (2001).

Hintz SR, Benaron DA, Siegel AM, Zourabian A, Stevenson DK and Boas DA. "Bedside functional imaging of the premature infant brain during passive motor activation." J Perinat Med 29: 335-343 (2001). PMID: 11565203

Hueber DM, Franceschini MA, Ma HY, Xu Q, Ballesteros JR, Fantini S, Wallace D, Ntziachristos V and Chance B. "Non-invasive and quantitative near-infrared hemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multi-distance instrument." Phys Med Biol 46: 41-62 (2001). PMID: 11197678


Benaron, DA, Hintz, SR, Villringer, A, Boas, DA, Kleinschmidt, A, Frahm, J, Hirth, C, Obrig, H, van Houten, JC, Kermit, EL, Cheong, WF, Stevenson, DK. "Noninvasive functional imaging of the human brain using light." J. Cerebral Blood Flow and Metabolism 20: 469-477 (2000). PMID: 10724111

Dunn, AK and Boas, DA, "Transport-based image reconstruction in turbid media with small source-detector separations." Optics Letters 25:1777-1779 (2000).

Franceschini, MA, Toronov, V, Filiaci, ME, Gratton, E and Fantini, S. "On-line optical imaging of the human brain with 160 ms temporal resolution." Opt Express 6: 49-57 (2000).

Gaudette, RJ, Brooks, DH, DiMarzio, CA, Kilmer, ME, Miller, EL, Gaudette, T and Boas, DA. "A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient." Phys. med. Biol. 45:1051-1070 (2000). PMID: 10795991

Kilmer, M, Miller, E, Boas, DA and Brooks, D. "A shape-based reconstruction technique for DPDW data." Optics Express 7:481-491 (2000).

Toronov, V, Franceschini, MA, Filiaci, ME, Wolf,M, Fantini, S and Gratton, E. "Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: Spatial mapping and temporal analysis.  Med Phys 27: 801-815 (2000). PMID: 10798703

Zourabian, A, Siegel, AM, Chance, B, Ramanujan, N, Rhode, M and Boas, DA, "Trans-abdominal monitoring of fetal arterial blood oxygenation using pulse oximetry." Journal of Biomedical Optics 5(4): 391-405 (2000). PMID: 11092427


Bizheva, KK, Siegel, AM, Dunn, AK and Boas, DA. "Detection of Multiply Scattered Light in Optical Coherence Tomography." Waves and Imaging through Complex Media. ed. Sebbah, P.Dordrecht: Kluwer Academic Publishers, 1999.277-298.

Cheng, X and Boas, DA. "Systematic diffuse optical image errors resulting from uncertainty in the background optical properties." Optics Express 4:299-307 (1999).

Fantini, S, Franceschini, MA, Gratton, E, Hueber, D, Rosenfeld, W, Maulik, D, Stubblefield, PG and Stankovic, MR. "Non-invasive optical mapping of the piglet brain in real time." Opt Express 4: 308-314 (1999).
Fantini, S, Hueber, D, Franceschini, MA, Gratton, E, Rosenfeld, W, Stubblefield, PG, Maulik, D and Stankovic, MR. "Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain methods." Phys Med Biol 44: 1543-1563 (1999). PMID: 10498522

Franceschini, MA, Gratton, E and Fantini, S. "Non-invasive optical method of measuring tissue and arterial saturation: An application to absolute pulse oximetry of the brain." Opt Lett 24 (12), 829-831 (1999).

Siegel, AM, Marota, JJA and Boas, DA. "Design and evaluation of a continuous-wave diffuse optical tomography system." Optics Express 4:287-298 (1999).


Bizheva, KK, Siegel, AM and Boas, DA. "Path-length resolved dynamic light scattering in highly scattering random media: The transition to diffusing wave spectroscopy." Phys. Rev. E 58:7664-7667 (1998).

Boas, DA, Bizheva, KK and Siegel, AM. "Using Dynamic Low Coherence Domain Interferometry to Image Brownian Motion within Highly Scattering Media." Optics Letters 23:319-321 (1998).

Cheng, X and Boas, DA. "Diffuse optical reflectance tomography with continuous-wave illumination." Optics Express 3:118-123 (1998).

Fantini, S, Walker, SA, Franceschini, MA, Moesta, KT, Schlag, PM, Kaschke, M and Gratton, E. "Assessment of the size, position, and optical properties of breast tumors in vivo by non-invasive optical methods." Appl Opt 37: 1982-1989 (1998).

Franceschini, MA, Fantini, S, Paunescu, LA, Maier, JS and Gratton, E. "Influence of a superficial layer in the quantitative spectroscopic study of strongly scattering media." Appl Opt 37: 7447-7458 (1998).

Moesta, T, Jess, H, Totkas, S, Fantini, S, Franceschini, MA, Kaschke, MA and Schlag, PM. "Contrast features of breast cancer in frequency-domain laser scanning mammography." J Biomed Opt 3: 129-136 (1998).

Walker, SA, Boas, DA and Gratton, E. "Photon density waves scattered from cylindrical inhomogeneities: Theory and Experiments." Applied Optics 37:1935-1944 (1998).


Boas, DA, O'Leary, MA, Chance, B and Yodh, AG. "Detection and characterization of optical inhomogeneities with diffuse photon density waves: a signal-to-noise analysis." Applied Optics 36:75-92 (1997).

Boas, DA and Yodh, AG. "Spatially Varying Dynamical Properties of Turbid Media Probed with Diffusing Temporal Light Correlation." J. Opt. Soc. Am. A 14:192-215 (1997).

Boas, DA. "A fundamental limitation of linearized algorithms for diffuse optical tomography." Optics Express 1:404-413 (1997).

Cerussi, AE, Maier, JS, Fantini, S, Franceschini, MA, Mantulin, WW and Gratton, E. "Experimental verification of a theory for the time-resolved fluorescence spectroscopy of thick tissues." Appl Opt 36: 116-124 (1997).

Durduran, TB, Chance, B, Yodh, AG and Boas, DA. "Does the photon diffusion coefficient depend on absorption?" J. Opt. Soc. Am. A 14:3358-3365 (1997). PMID: 9392901

Fantini, S, Barbieri, B, Franceschini, MA and Gratton, E. "Frequency-domain spectroscopy." in Applications of Optical Engineering to the Study of Cellular Pathology. E. Kohen, Ed. (Research Signpost, Trivandum, India, 1997) pp. 57-66.

Fantini, S, Franceschini, MA and Gratton, E. "Effective source term in the diffusion equation for photon transport in turbid media." Appl Opt 36: 156-163 (1997).

Franceschini, MA, Fantini, S, Cerussi, AE, Barbieri, B, Chance, B and Gratton, E. "Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: Analysis of the effect of water absorption."  J Biomed Opt 2: 147-153 (1997).

Franceschini, M.A., Moesta, K.T., Fantini, S., Gaida, G., Gratton, E., Jess, H., Mantulin, W.W., Seeber, M., Schlag, P.M. and Kaschke, M. (1997). "Frequency-domain techniques enhance optical mammography: initial clinical results." Proc Natl Acad Sci U S A 94(12): 6468-6473. PMID: 9177241

Gratton, E, Fantini, S, Franceschini, MA, Gratton, G and Fabiani, M. "Measurement of scattering and absorption changes in muscle and brain." Phil Trans R Soc of Lond B 352: 727-735 (1997).

1996 and Earlier

Boas DA, Campbell LE and Yodh AG. "Scattering and Imaging with Diffusing Temporal Field Correlations." Physical Review Letters 75(9): 1855-1858 (1995)

Boas DA, O'Leary, MA, Chance B and Yodh AG. "Scattering of Diffuse Photon Density Waves by Spherical Inhomogeneities Within Turbid Media: Analytical Solution and Applications." PNAS 91: 4887-4891 (1994).

Boas DA, O'Leary MA, Chance B and Yodh AG. "Scattering and wavelength transduction of diffuse photon density waves." Physical Review E 47(5): R2999-R3002 (1993).

De Blasi RA, Fantini S, Franceschini MA, Ferrari M, and Gratton E. Cerebral and Muscle Oxygen Saturation Measurement by Frequency-Domain Near-Infra-red Spectrometer. Med Biol Eng Comput 33, 228-230 (1995).

Fantini S, Franceschini, MA, Gaida G, Gratton E, Jess H, Mantulin WW, Moesta KT, Schlag PM, and Kaschke M. Frequency-Domain Optical Mammography: Edge Effect Corrections. Med Phys 23, 149-157 (1996).

Fantini S and Franceschini MA. Studio Ottico di Tessuti Biologici nel Vicino Infrarosso: Spettroscopia e Tomografia. ("Optical Study of Biological Tissues in the Near-Infrared: Spectroscopy and Tomography"), in Laser e Luce in Chirurgia e Medicina ed in Biotecnologia (Laser and Light in Surgery and Medicine and in Biotechnology), R. Pratesi, ed., (Consiglio Nazionale delle Ricerche-Area della Ricerca di Firenze, Florence, Italy, 1995), pp. 415-426.

Fantini S, Franceschini MA, Maier JS, Walker SA, Barbieri B, and Gratton E. Frequency-Domain Multichannel Optical Detector for Non-Invasive Tissue Spectroscopy and Oximetry. Opt Eng 34, 32-42 (1995).

Fantini S, Franceschini MA, and Gratton E. Semi-Infinite-Geometry Boundary Problem for Light Migration in Highly Scattering Media: a Frequency- Domain Study in the Diffusion Approximation. J Opt Soc Am B 11, 2128-2138 (1994).

Fantini S, Franceschini MA, Fishkin JB, Barbieri B, Gratton E. Quantitative Determination of the Absorption Spectra of Chromophores in Strongly Scattering Media: a Light-Emitting-Diode Based Technique. Appl Opt 33, 5204-5213 (1994).

Fishkin JB, So PTC, Cerussi AE, Fantini S, Franceschini MA, and Gratton E. Frequency-Domain Method for Determining Spectral Properties in Multiply Scattering Media: Methemoglobin Absorption Spectrum in a Tissue-Like Phantom. Appl Opt 34, 1143- 1155 (1995).

Franceschini MA, Pini R, Salimbeni R, Vannini M. Auto-Prepulse Operation of a Long-Pulse XeCl Laser. Appl Phys B 54, 259-264 (1992)

Gratton E, Fantini S, Franceschini MA, Walker S, and Maier JS. Spectroscopy and tomography of tissues in the frequency-domain. in Analytical Use of Fluorescent Probes in Oncology NATO ASI Series, Series A: LIfe Sciences Vol. 286, E. Kohen and J. G. Hirschberg, eds., (Plenum Press, New York, 1996), pp. 41-52.

Gratton G, Fabiani M, Friedman D, Franceschini MA, Fantini S, Corballis PM, and Gratton E. Rapid Changes of Optical Parameters in the Human Brain During a Tapping Task. J. Cogn Neuroscience7, 446-456 (1995).

Li XD, O'Leary MA, Boas DA, Chance B and Yodh AG. "Fluorescent diffuse photon density waves in homogeneous and heterogeneous turbid media: analytic solutions and applications." Applied Optics 35(19): 3746-3758 (1996).

Maier JS, Walker SA, Fantini S, Franceschini MA and Gratton E. Possible Correlation between Blood Glucose Concentration and Reduced Scattering Coefficient of Tissues in the Near-Infrared. Opt Lett 19, 2062-2064 (1994).

O'Leary MA, Boas DA, Chance B and Yodh AG. "Experimental images of heterogeneous turbid media by frequency-domain diffusing photon tomography."  Optics Letters 20(5): 426-428 (1995).

O'Leary MA, Boas DA, Li XD, Chance B and Yodh AG. "Fluorescence lifetime imaging in turbid media." Optics Letters 21(2): 158-160 (1996).

O'Leary MA, Boas DA, Chance B and Yodh AG. "Refraction of diffuse photon density waves." Physical Review Letters 69(18): 2658-2662 (1992).


David Boas